Clinical Characteristics and Outcomes of Paediatric Patients with Coronavirus Disease (COVID-19): A Single Center Study in Bangladesh (original) (raw)
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COVID-19 in Children: Experience from a Tertiary Care Hospital in Bangladesh
Open Journal of Pediatrics
Background: Children are generally at low risk of infection and data on COVID-19 in children are scarce. This study was undertaken to document data from a tertiary care hospital in Bangladesh on the incidence, presentation and immediate outcome of COVID-19 in children. Methodology: It was a crosssectional study conducted in the fever clinic and the department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU) over a period of one year from July 2020 to June 2021. All the RT-PCR positive pediatric cases (1 month to 18 years) were enrolled. Data were collected by a structured, predesigned and pre-tested questionnaire. Data were analyzed using Microsoft Excel spreadsheet software 2010. Frequency, percentage and chi-square tests were done for statistical analysis. Result: Among 8203 suspected pediatric COVID-19 cases, 850 (10.36%) was RT PCR positive. The highest number of RT-PCR positive COVID-19 cases was found in April 2021. More than 63% of cases were in the age group of 10 to 18 years. Male: female ratio was 0.97:1. Fever was the most common (75.9%) presenting feature followed by breathing difficulty and chest pain in 9.6% and 7% of patients respectively. Mild infection group was predominant (56.7%). Among the symptomatic cases, 16.7% were hospitalized. Oxygen inhalation and bronchodilators were needed in 75% of hospitalized patients. All the severe and critical cases were managed in the inpatient department and in pediatric PICU when indicated. Most of the patients (99.4%) improved with or without any complication. Four critically ill patients (0.75%) developed multi-organ dysfunction and expired in PICU. Conclusion: The majority of COVID-19 cases belonged to the older age group. More than 75% cases were symptomatic. History of contact was present in 78% cases. More than 99% children recovered with or without sequelae and 0.8% children with pre-existing co-morbidities expired.
Clinico-Epidemiological Characteristics of Pediatric COVID-19 Patients in Bangladesh
2021
Background To delineate the clinico-epidemiological characteristics of pediatric coronavirus disease-2019 (COVID-19) patients was the objective of the study. Method: This observational study included 290 pediatric patients with a definite diagnosis of COVID-19 admitted to Dhaka Shishu Hospital, Bangladesh, from April 2021 to October 2021. Clinical and epidemiological characteristics were analyzed based on demographic data, medical history, laboratory tests, and outcome information. Data analysis was performed with SPSS 26. Ethical measures were taken in compliance with the current declaration of Helsinki, and final analysis was performed using SPSS 26. Result Of all, 42 (14.5%) were neonates (
Asian Journal of Pharmaceutical and Clinical Research, 2023
Objective: Coronavirus disease-19 (COVID-19) infection has quickly developed into a global pandemic. According to the available evidence, children appear to be less likely to be afflicted and the condition may be less severe, but things could change. Rapid deterioration and enhancements in the physiologic state are a hallmark of the pediatric community. Therefore, this study was conducted with the aim to study the demographic and clinical parameters of pediatric COVID patients. Methods: This hospital-based prospective and retrospective study was conducted during April 1 st , 2020-July 2022 at the COVID ward and outpatient department, Mahatma Gandhi Medical College and Hospital, Jaipur. We included 276 children up to 18 years suffering from COVID-19 infection. We collected data of our study population from medical records and filled up the predesigned pro forma for admitted patients. Admitted children were classified as, per ICMR guidelines as: asymptomatic, mild, moderate, and severe variety. Statistical analysis was done with the SPSS software. Results: Highest percentage of cases 48.39% in the age group 12-18 years, were followed by 31.45% in the 7-12-year-old age group. About 13.04% of patients were asymptomatic, whereas the remaining cases were symptomatic, with severity levels of mild 49.28%, moderate 26.81%, and severe 10.87%. Fever was the most prevalent symptom 69.2%, cough at 43.84%, throat ache 18.12%, breathing difficulties 15.22%, headache 2.54%. Conclusion: In the present study, we concluded that during the third wave of the pandemic, most children had symptomatic illnesses, but recovery was fast among non-hospitalized children. Multisystem inflammatory syndrome in children was more common in elderly children.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Introduction: There has been adequate evidence that children are less likely to contract the Coronavirus Disease-2019 (COVID19) infection and less likely to experience a deadly course of the disease in the paediatric group. The majority of the time, they exhibit moderate respiratory symptoms, like fever, dry cough and exhaustion. They were all free of COVID-19 pneumonia. Aim: To compare the clinical features and short-term outcomes of COVID-19 in children during May 2020 to April 2022. Materials and Methods: The present analytical observational study was conducted in the Department of Paediatrics, Chettinad Hospital, Chennai, Tamil Nadu, India, from March 2020 to March 2022. The study population included Reverse TranscriptionPolymerase Chain Reaction (RT-PCR) positive COVID-19 children between age groups of one month and 18 years age. A sample size of 102, 90 and 98 were included from first, second and third wave, respectively. Kruskal-Wallis test and Analysis of Variance (ANOVA) te...
Profile and Outcome of Children with COVID-19 Attending Bangabandhu Sheikh Mujib Medical University
American Journal of Pediatrics, 2021
Background: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a global pandemic. Covid-19 has spread around Bangladesh and children are also being infected with comparatively fewer symptoms and lower case-fatality rates. Objectives: To assess the clinical profile, disease severity, presence of co-morbidities and outcome of pediatric COVID-19 patients. Methods: This prospective observational study was conducted in the fever clinic and the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU). Data were collected from the confirmed cases by using a structured questionnaire by face to face interview and also over telephone at 1 st visit and at 2 nd and 8 th week of disease course. Collected data were analyzed using appropriate statistical tests. Result: Among 2091 suspected COVID 19 cases attending fever clinic and department of Pediatrics, 462 (22.09%) were real time polymerized chain reaction (RT PCR) COVID 19 positive. Of them 377 (81.60%) responded to the questionnaire and subsequent follow up. Highest numbers of cases were found in June 2020. More than 60% of cases were within the age group of 10 to 18 years and 3.44% were infants. Male: female ratio was 1.04:1. Associated co-morbid conditions were present in 21.48% patients. Fever was the most common (72.67%) clinical feature followed by others. Incidences of severe and critical illness were more in older children. Most of the moderate cases and all of the severe and critical COVID cases were managed in the inpatient department including Pediatric intensive care unit. Among them, 100% required oxygen therapy, 72.41% needed oral or IV steroids, 8.6% and 6.9% needed intravenous immunoglobulin and biological agents (Tocilizumab) respectively. Seventeen patients (4.5%) recovered with some complications. Conclusions: Among suspected cases 22% were RT-PCR positive. Majorities were in the older age group and most of the moderate and all the severe and critical cases also belonged to older age group. Most of the cases (94.42%) recovered without complication and 4.5% recovered with some complications. Mortality was 1.06%.
Clinical Profile of COVID-19 Illness in Children—Experience from a Tertiary Care Hospital
2021
To detail clinical profile and outcome in children infected with SARS-CoV-2. This retrospective study was undertaken at a tertiary care pediatric teaching hospital in Northern India. The data on clinical characteristics and outcome of children (< 18 y) with COVID-19 illness from April 2020–October 2020 were reviewed and analyzed. A total of 2919 children with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) illness were tested for novel COVID-19 virus in the flu emergency (n = 1744), severe acute respiratory infection (SARI) ward (n = 825), and non-COVID area (n = 350) of the hospital. 8.73% (255/2919) children tested positive for SARS-CoV-2 infection. Of the 255 positive cases, 144 (56.47%) were managed on an outpatient basis and 100 (59 boys) required admission in COVID ward. The mortality rate of patients with SARS-CoV-2 was 11.4% (29/255). Majority of children admitted with COVID-19 had severe to critical illness due to the presence of malnutrition and u...
Clinical Profile of COVID-19 Illness in Children—Experience from Tertiary Care Hospitals
Pakistan Journal of Medical and Health Sciences, 2022
Objective: Assessing detailed clinical profile as well as outcome in severe acute respiratory infection coronavirus infectious disease 2 (SARS-CoV-2) infected children. Methods: This is a retrospective study undertaken at pediatric departments of tertiary care hospitals of Lahore, Rawalpindi and Mirpur AJK for the period of three months from July 2021 to September 2021. The clinical characteristics data as well as result of children under 18 years infected with COVID-19 were reviewed as well as analyzed. Results: In total 2919 children that were suspected to be COVID-19 infected were verified for COVID-19 virus in flu emergency (n = 1744), severe acute respiratory infection ward (n = 825) and non-COVID (n = 350). From these studies, 8.73% children tested positive for COVID-19 infection. Of the positive cases, 56.47% were managed for outpatients and 59% needed admission. Most children admitted had critical illness owing to malnutrition and other comorbidities. Conclusions: Children of any age group are vulnerable to COVID-19 with minor male preponderance. Amongst infected, 2/3 rd were asymptomatic or mildly symptomatic and needed outpatient management as well as home isolation. The adverse consequences were commonly observed in infants as well as children under 10 years of age with undernourishment and comorbidity.
Demographic, Clinicopathological Profile and Outcomes of COVID-19 among Hospital Admitted Children
Bangladesh Journal of Infectious Diseases
Background: Although the corona virus disease 2019 (COVID‐19) outbreak is a global public health challenge, clinical patterns of children with COVID‐19 still remain unclear as most studies on COVID- 19 have focused on adults and only a small number of studies included pediatric patients. Objective: This study was done to observe the demographic profile, clinical presentation, laboratory finding and outcome of hospital-admitted children diagnosed as COVID-19. Method: This was a observational study done in Department of Paediatrics at Holy Family Red Crescent Medical College Hospital, Dhaka, Bangladesh from October 2021 to March 2022 for duration of six month. This study included all admitted children from newborn up to 14 years of age diagnosed with COVID-19 either by RT-PCR or by HRCT scan of the chest. Results: Among 35 patients mean age was 48.64 ± 63.10 month and 62.8% were male and 37.1% were female. Most common presentations were fever and cough both were (77.1%) followed by di...
Anwer Khan Modern Medical College Journal
Background: Corona virus disease is a global health crisis, a surprising feature of the disease reflects that children might be less affected in the initial stage. Previous studies suggest that COVID-19 more likely to infect adults, but paediatric patients are on the rise. In most of the cases children have mild or moderate symptom of COVID-19, but another new serious presentation emerged named Multisystem inflammatory syndrome in children (MIS-C) which includes features like Kawasaki disease or toxic shock syndrome. The past few months we have seen a lot of findings and variation regarding the COVID-19 illness. As childhood presentation are variable analyzing the pattern of disease in children helps the policy makers to make the better strategies and health care givers to serve better. Objectives: This study was conducted to assess the age and sex distribution, clinical presentations, morbidity, mortality pattern in children with COVID-19 infection. Methods: This descriptive study ...