Open Access (original) (raw)

2016

Abstract

Aim The role of interleukin 17A (IL-17A) in the inflammatory process has caused interest in the potential significance of IL-17A as a biomarker for coronary artery disease (CAD). The aim of the present study was to evaluate the role of IL-17A gene polymorphisms as susceptibility markers for CAD in the Mexican population. Methods Four IL-17A gene polymorphisms (rs8193036, rs3819024, rs2275913 and rs8193037) were genotyped by 5 ’ exonuclease TaqMan assays in a group of 900 patients with prema-ture CAD and 667 healthy controls (with negative calcium score by computed tomography), seeking associations with CAD and other metabolic and cardiovascular risk factors using lo-gistic regression analyses. Results No single IL-17A polymorphism was associated with premature CAD, however two haplo-types (CAGG and TAGA) were significantly associated with increased risk of premature

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