Staphylococcus aureus in relation to physical, physiological and subjective conditions of apparently normal human skin (original) (raw)
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Skin Colonization With Staphylococcus Aureus In Patients With Atopic Dermatitis
The Internet Journal of Dermatology, 2007
Objectives: To investigate the presence of S. aureus in the skin of AD patients and compare with healthy control group. Patients/Methods: Forty patients with AD were recruited in to our study. S. aureus skin colonization was determined in AD patients and controls, also skin distribution of S. aureus colonization was compared in three age groups of AD patients. Results: S. aureus was found on the skin of 42.5% and 7.5% of AD patients and control group, respectively (p=0.0003). The most common involved skin areas with S. aureus colonization were face (in ≤2 yrs old), flexor surfaces (in >2 and ≤12 yrs old) and extremities (in >12 yrs old). Conclusions: The incidence of S. aureus on the skin of AD patients was considerably higher rather than controls. Further studies are needed to investigate the clearance of S. aureus from the skin of AD patients using anti-staphylococcal treatment.
2013
The skin of children with atopic dermatitis (AD) is colonized with Staphylococcus aureus more frequently than that of their peers. We investigated the prevalence of skin and nares colonization by S. aureus in children with AD, the virulence genes of the isolates, and their association with allergy, AD severity, and serum vitamin D (25(OH)D). This was an observational, cross-sectional study in a sample of children diagnosed with AD in two settings in Spain. The samples were collected in 2012. Swabs from affected skin and nares were taken for microbiologic culture. The prevalence of S. aureus and presence of 17 staphylococcal virulence genes were studied using polymerase chain reaction. A total of 114 patients with a mean age of 5.7 AE 4.1 (range 3 mos to 14 yrs) were included in the study. Swabs were taken from the skin of 113 individuals with AD and from the nares of 85; 28.3% had S. aureus on the skin, which was significantly associated with positive allergen-specific immunoglobulin E antibodies and higher Scoring Atopic Dermatitis (SCORAD) scores in the multivariate analysis. The presence of virulence factors tsst-1, eta, cna, aur, and sec in cutaneous S. aureus isolates was associated with lower serum levels of 25(OH)D. S. aureus on nasal swabs correlated with its presence on the skin and was associated with lower 25(OH)D levels. In conclusion, S. aureus colonization is associated with allergy and severity
Staphylococcus aureus colonization in atopic skin diseases
İnönü Üniversitesi Turgut Özal Tıp Merkezi dergisi, 1996
Background: Atopic dermatitis (AD) is a prevalent disease with significant impact on physical health and quality of life. Staphylococcus aureus (S. aureus) has been directly correlated to disease severity, and may also be a contributing causal factor in the pathogenesis of AD. The primary aim of the present study was to assess differences in S. aureus colonization in AD patients with and without filaggrin gene (FLG) mutations. Secondarily, to assess disease severity in relation to S. aureus colonization. Exploratory analyses were performed to investigate S. aureus genetic lineages in relation to FLG mutations and disease severity (SCORAD). Methods: 101 adult AD patients were included in the study. Bacterial swabs were taken from lesional skin, non-lesional skin and nose. Swabs positive for S. aureus were characterized by spa and the respective clonal complex (CC) type assigned. Patients were characterized with respect to disease severity (SCORAD) and FLG mutations (n=88). Fischer's exact test was Accepted Article This article is protected by copyright. All rights reserved. used to analyze differences in S. aureus colonization in relation to FLG mutations. Results: Of the 101 patients included, 74 patients (73%) were colonized with S. aureus. Of the colonized patients, 70 patients (95%) carried only one CC type in all three different sampling sites. In lesional skin S. aureus was found in 24 patients with FLG mutations (n=31), versus 24 wild-type patients (n=54) (p=0.0004). S. aureus CC1 clonal lineage was more prevalent in patients with FLG mutations (n=10) than in wild-type patients (n=2) (p=0.003). No specific bacterial lineage was linked to disease severity. Conclusion: Increased S. aureus colonization in AD patients with FLG mutations, and increased prevalence of CC1 in patients with FLG mutations, suggest that host-microbe interactions and clonal differences in S. aureus are important for colonization of AD skin.
Staphylococcus Aureus Colonization In Atopic Dermatitis Patients
Journal of dermatology and dermatitis, 2019
Background: Atopic dermatitis (AD) is a prevalent disease with significant impact on physical health and quality of life. Staphylococcus aureus (S. aureus) has been directly correlated to disease severity, and may also be a contributing causal factor in the pathogenesis of AD. The primary aim of the present study was to assess differences in S. aureus colonization in AD patients with and without filaggrin gene (FLG) mutations. Secondarily, to assess disease severity in relation to S. aureus colonization. Exploratory analyses were performed to investigate S. aureus genetic lineages in relation to FLG mutations and disease severity (SCORAD). Methods: 101 adult AD patients were included in the study. Bacterial swabs were taken from lesional skin, non-lesional skin and nose. Swabs positive for S. aureus were characterized by spa and the respective clonal complex (CC) type assigned. Patients were characterized with respect to disease severity (SCORAD) and FLG mutations (n=88). Fischer's exact test was Accepted Article This article is protected by copyright. All rights reserved. used to analyze differences in S. aureus colonization in relation to FLG mutations. Results: Of the 101 patients included, 74 patients (73%) were colonized with S. aureus. Of the colonized patients, 70 patients (95%) carried only one CC type in all three different sampling sites. In lesional skin S. aureus was found in 24 patients with FLG mutations (n=31), versus 24 wild-type patients (n=54) (p=0.0004). S. aureus CC1 clonal lineage was more prevalent in patients with FLG mutations (n=10) than in wild-type patients (n=2) (p=0.003). No specific bacterial lineage was linked to disease severity. Conclusion: Increased S. aureus colonization in AD patients with FLG mutations, and increased prevalence of CC1 in patients with FLG mutations, suggest that host-microbe interactions and clonal differences in S. aureus are important for colonization of AD skin.
The role of the staphylococci in dermatology
Journal of the European Academy of Dermatology and Venereology, 1996
Aim To describe the prevalence of Staphylococcus aureus in atopic dermatitis. Subject Atopic dermatitis and Staphylococcus aureus. Results Amongst the staphylococci, only S. aureus is implicated in skin infection. Much localised infection, such as folliculitis or furunculosis, is endogenous, that is the result of infection with organisms carried in the nose or at specific skin sites. In contrast impetigo and scalded skin syndrome are chiefly exogenous in origin. Secondary infection, for example in atopic dermatitis, is also associated with nasal and skin carriage. Much remains to be learned of the pathogenesis of staphylococcal infection and much current interest derives from the superantigenic activity of the exotoxins and toxic shock toxin. Conclusion Staphylococcus aureus occurs with increased incidence on the skin of patients with atopic dermatitis. It could be responsible for activating eczema via secretion of exotoxins.
Staphylococcus aureus in acne pathogenesis: A case-control study
North American Journal of Medical Sciences, 2012
Background: There is considerable evidence which suggests a possible pathogenetic role for Staphylococcus aureus (S. aureus) in acne vulgaris. Aim: The study was to determine S. aureus colonization and antibiotic susceptibility patterns in patients with acne and of healthy people. Materials and Methods: In the case-control study, a total of 324 people were screened for nasal carriage of S. aureus: 166 acne patients and 158 healthy persons. One control subject was individually matched to one case. Nasal swabs from anterior nares of individuals were cultured and identified as S. aureus. Antibiotic sensitivity was performed with recognized laboratory techniques. Results: S. aureus was detected in 21.7% of the subjects in acne, and in 26.6% of control groups. There was no statistical difference in colonization rates between two groups (P=0.3). In patient group, most of S. aureus isolates were resistant to doxicycline and tetracycline (P=0.001), and were more sensitive to rifampicin compared to other drugs. In control samples, the isolated demonstrated higher resistance to cotrimoxazole compared to patient samples (P=0.0001). There was no difference between groups regarding resistance to rifampicin, vancomycin, methicillin, and oxacillin. Conclusion: It is still unclear whether S. aureus is actually a causal agent in the pathogenesis of acne. Based on microbiological data of both healthy and acne-affected persons, we propose that contribution of S. aureus in acne pathogenesis is controversial.
Anais Brasileiros de Dermatologia, 2013
BACKGROUND:Atopic dermatitis leads to epidermal barrier dysfunction and bacteria colonization. The relationship of the last factor with the severity of the disease and the frequency of exacerbation is not fully known.OBJECTIVES:Verify the severity of the atopic dermatitis and the number of appointments generated by dermatosis, comparing patients colonized with patients not colonized by S. aureus. Verify the frequency of colonization by methicillin resistant Staphylococcus aureus acquired in the community.METHODS:Cohort study with a 12 months follow-up, in a sample of patients from Porto Alegre, RS public network. Cultures in active injuries and nasal cavities were carried out as well as methicillin sensitivity tests to S. aureus.The severity of atopic dermatitis was defined by Eczema Area and Severity Index (EASI).RESULTS:We included 93 patients, 43% female and 56% male, 26 colonized by S. aureusin the nasal orifices, 56 in the skin damage. The mean of initial Eczema Area and Severi...
Acta Dermato Venereologica, 2017
The aim of this study was to monitor Staphylococcus aureus colonization and disease severity in adults with atopic dermatitis (AD) during 5 months. Twenty-one patients attended 3 visits each for severity SCORing of Atopic Dermatitis (SCORAD) assessment, quantitative cultures from the skin and conventional cultures from the anterior nares, tonsils and perineum. S. aureus isolates were typed for strain identity with pulsed-field gel electrophoresis (PFGE). Seventy-one percent of patients were colonized with S. aureus on lesional skin at least once. Density (colony-forming units (CFU)/ cm 2) was higher on lesional skin than on non-lesional skin (p < 0.05). Density on lesional skin and number of colonized body sites were positively correlated with SCORAD (p = 0.0003 and p = 0.007, respectively). Persistent carriers of the same strain on lesional skin had higher mean SCORAD index than intermittent/noncarriers (36.3 and 17.1, respectively, p = 0.002). The results show a temporal correlation between several aspects of S. aureus colonization and disease severity in AD raising the question of the importance of this in pathogenesis and treatment.