The Role of ATP-Sensitive Potassium Channels in Neutrophil Migration and Plasma Exudation (original) (raw)

2002, Journal of Pharmacology and Experimental Therapeutics

Neutrophil activation and migration during an inflammatory response is preceded or accompanied by plasma membrane electrical changes. Besides changes in calcium currents, neutrophils have a high permeability to potassium, mainly through potassium channels. However, the significance of potassium channels in neutrophil physiology is still unclear. Here, we show that the treatment of rats with the ATP-sensitive potassium channel blocker glibenclamide (4, 20, or 40 mol/kg) dose dependently decreased carrageenan-, N-formyl-methionylleucyl-phenylalanine (fMLP)-, and lipopolysaccharide-induced neutrophil influx and fluid leakage into the interpleural space.

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