Calcium phosphates as substitution of bone tissues (original) (raw)
Related papers
Nanomaterials
Biogenic calcium carbonates naturally contain ions that can be beneficial for bone regeneration and therefore are attractive resources for the production of bioactive calcium phosphates. In the present work, cuttlefish bones, mussel shells, chicken eggshells and bioinspired amorphous calcium carbonate were used to synthesize hydroxyapatite nano-powders which were consolidated into cylindrical pellets by uniaxial pressing and sintering 800–1100 °C. Mineralogical, structural and chemical composition were studied by SEM, XRD, inductively coupled plasma/optical emission spectroscopy (ICP/OES). The results show that the phase composition of the sintered materials depends on the Ca/P molar ratio and on the specific CaCO3 source, very likely associated with the presence of some doping elements like Mg2+ in eggshell and Sr2+ in cuttlebone. Different CaCO3 sources also resulted in variable densification and sintering temperature. Preliminary in vitro tests were carried out (by the LDH assay)...
Data in brief, 2017
The data presented in this article are related to the research article entitled "Biphasic calcium phosphates bioceramics (HA/TCP): Concept, physicochemical properties and the impact of standardization of study protocols in biomaterials research" [1]. This article provides in depth study of BCP bone substitutes as valuable option in the field of tissue engineering. However, there are discrepancies in the literature regarding the ideal physicochemical properties of BCP and the ideal balance between different phase compositions for enhanced bone tissue engineering (M. Ebrahimi, M.G. Botelho, S.V. Dorozhkin, 2016; M. Ebrahimi, P. Pripatnanont, S. Suttapreyasri, N. Monmaturapoj, 2014) [1,2]. This is found to be mainly because of improper characterization of BCP bioceramics in basic studies and lack of standard study protocols in in vitro and in vivo research. This data article along with original article provide the basic data required for ideal characterization of BCP and othe...
Special Issue: Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates
Materials
Research on calcium phosphate use in the development and clinical application of biomedical materials is a diverse activity and is genuinely interdisciplinary, with much work leading to innovative solutions for improvement of health outcomes. This Special Issue aimed to summarize current advances in this area. The nine papers published cover a wide spectrum of topical areas, such as (1) remineralisation pastes for decalcified teeth, (2) use of statins to enhance bone formation, (3) how dolomitic marble and seashells can be processed into bioceramic materials, (4) relationships between the roughness of calcium phosphate surfaces and surface charge with the effect on human MRC osteogenic differentiation and maturation being investigated, (5) rheological and mechanical properties of a novel injectable bone substitute, (6) improving strength of bone cements by incorporating reinforcing chemically modified fibres, (7) using adipose stem cells to stimulate osteogenesis, osteoinduction, an...
2018
Hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) and their composites with natural polymers are widely used as filler materials for their biocompatibility and osteoconductivity. A three dimensional interconnection of both macroand micro-pores (biomodal pores) is important for a porous scaffold, because macropores allow cell, blood vessel and tissue ingrowths and micropores serve as an effective pathway for exchange of fluid in which nutrition and wastes are dissolved. Marine derived biomaterials from corals, cuttlebones, sea urchin spines etc., have shown good potential as bone substitutes due to their interconnected porous structure and ease of conversion to calcium phosphate without any change in their original porous structure. However, corals are considered as reservoir of carbonate gas to decrease greenhouse effect and not recommended to collect from sea, cuttlebones consist of only macropores and sea urchin spines consist of only micropores. Contrarily, gonads of sea urchi...
CALCIUM PHOSPHATE AS A BIOMATERIAL AND ITS USE IN BIOMEDICAL APPLICATIONS
Calcium phosphate (CaP) based biomaterials are similar to bone mineral in composition and in some properties such as biodegradability, bioactivity, osteoinductive properties (achieved by appropriate geometry topography or combining with growth factors or bioactive proteins) and protein adhesion. This makes them a popular choice as a substitute material that can be used for teeth or bone replacement, bone repair, augmentation or regeneration.