Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors (original) (raw)
Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor
Laszlo Hevesi
Bioorganic & Medicinal Chemistry Letters, 2009
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Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity
Didier Desmaële
Bioorganic & Medicinal Chemistry Letters, 2004
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HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Ashwanth Francis
eLife
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Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity
Antonella Converso
ACS chemical biology, 2017
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Development of an AlphaScreen-Based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors
Maurizio Botta
Journal of Biomolecular Screening, 2012
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New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Roman Sakowicz
Journal of Biological Chemistry, 2012
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Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action
Antonio Lavecchia
2006
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Progress in HIV-1 Integrase Inhibitors: A Review of their Chemical Structure Diversity
zahra hajimahdi
Iranian journal of pharmaceutical research : IJPR, 2016
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Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic Site Integrase Inhibitor
Stephen Kawai
Antimicrobial Agents and Chemotherapy, 2014
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Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1
Punit Bhardwaj
ACS Medicinal Chemistry Letters, 2014
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Novel HIV-1 Integrase Inhibitors Derived from Quinolone Antibiotics
Nnamdi Mcben
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Design and Development of Integrase Inhibitors as Anti-HIV Agents
A. Nagappa
Current Medicinal Chemistry, 2003
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Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities
Antonio Lavecchia
Journal of Medicinal Chemistry, 2008
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Kuwanon-L as a new allosteric HIV-1 integrase inhibitor: molecular modeling and biological evaluation
Francesca Esposito, Valentina Iovine, R. Ferrarese, F. Canducci, Angela Corona, Andrea Calcaterra
Chembiochem : a European journal of chemical biology, 2015
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A unique conformational escape reaction of HIV-1 against an allosteric integrase inhibitor
Masayuki Amano
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A Versatile and Practical Synthesis toward the Development of Novel HIV-1 Integrase Inhibitors
Giulia Vignaroli
ChemMedChem, 2011
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Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
Yehuda Goldgur
Proceedings of the National Academy of Sciences, 1999
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Toward novel HIV1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies
Suvi Rajamaki
Bioorganic & Medicinal Chemistry Letters, 2007
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Styrylquinoline Derivatives: A New Class of Potent HIV-1 Integrase Inhibitors That Block HIV-1 Replication in CEM Cells
Christian Auclair
Journal of Medicinal Chemistry, 1998
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HIV1 integrase strand-transfer inhibitors: Design, synthesis and molecular modeling investigation
Laura De Luca
European Journal of Medicinal Chemistry, 2011
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A QSAR Study on Some Series of HIV-1 Integrase Inhibitors
Shikha Kaushik
Medicinal Chemistry, 2011
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Study of inhibitory mechanism and binding mode of the thiazolo quinazoline compounds to HIV-1 integrase by docking
Arvind Kumar
2010
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A refined pharmacophore model for HIV1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series
Laura Luca
Bioorganic & Medicinal Chemistry Letters, 2008
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