Binahong leaf extract (anredera cordifolia) mucoadhesive patch as an alternative therapy for recurrent aphthous stomatitis (original) (raw)
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Althea Medical Journal, 2014
Background: Wound caused by trauma poses challenging daily clinical problems for physicians in hospitals and other health services. It has high risk for mortality and morbidity. Binahong [Anredera Cordifolia (Ten.) Steenis] plant originates from China and can be found abundantly in Indonesia. The objective of this research is to investigate the effect of topical application of Binahong leaf paste on wound healing process. Methods: A laboratory experimental study was conducted at the Pharmacology Laboratory, Universitas Padjadjaran, from October to December 2012 by using 27 Mus Muscularis mice which were divided into 3 groups: group 1 (sodium chloride 0.9%), group 2 (Binahong) and group 3 (povidone iodine 5%). Binahong leaves were crushed and were mixed with water to make a paste. The application was given for 12 days. On day zero, 1.0 cm 2 of wound was incised at the back of the mice, and further on day 1, 4, 8 and 12, the percentage of wound contraction was measured. The data was analyzed using Mann-Whitney test. Results: The study indicated that the percentage of wound contraction in group 2 on day 4 (1.17%), day 8 (23.7%) and day 12 (76.14%) is the highest among all groups. The result showed that the comparison between binahong and NaCl was highly significant on day 12, p= 0.001 (p < 0.05) and the data for comparison between Binahong and povidone iodine on day 12 was significant with p= 0.003 (p < 0.05). Conclusions: Topical application of Binahong leaf paste shows better result in wound healing process of Mus muscularis mice. From this study it can be concluded that binahong promotes wound healing and can be used for home remedies for wound care and as an alternative traditional way to treat wound.
International Journal of Applied Pharmaceutics, 2021
The objective was to describe and recommend the most effective combination of Natural-Based Product (NBP) and mucoadhesive for Recurrent Aphthous Stomatitis (RAS) treatment. This systematic review writing was based on PRISMA guidelines. The articles published in the last 10 y were selected using PubMed and Google Scholar database carried out during May 2021. The keywords were: natural-based product, mucoadhesive, and Recurrent Aphthous Stomatitis. The risk of bias was assessed using the Oxford Quality Scoring System. Six articles of Randomized Controlled Trial were selected. The NBP were: Aloe vera, Myrrh, Curcuma longa, propolis, ginger, Punica granatum flower, and sesame oil. The drug's formulation was: gel, film, and spray. The mucoadhesive polymers as vehicles were Hydroxy Propyl Ethyl Cellulose (HPEC), Hydroxy Propyl Methylcellulose (HPMC), Benzocaine, Tragacanth Gum, Carbomer 934, Sodium CMC (carboxymethyl cellulose), and chitosan. Curcuma longa 10 mg/g with HPMC was the most effective to relieve pain, while Punica granatum flower extract with Carbomer 934 and Sodium CMC was the most effective to reduce the ulcer size in RAS. Both of the formulations were in gel form.
Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review
Bioscientia Medicina : Journal of Biomedicine and Translational Research, 2021
A mouth ulcer or recurrent aphthous stomatitis (RAS) is a mouth mucous tissue inflammation. This disease mainly occurs in patients 10-40 years of age, preferably in women and high socioeconomic backgrounds. The cause of mouth ulcers or RAS could be trauma, infection, digestive problems, or blood disorders. Herbal practitioners widely use herbs, folks, and society to treat various diseases. This research aimed to describe the herbal treatment for RAS. The review results show there are nine plants with the ability to cure RAS, they are Persea americana Mill., Averrhoa bilimbi L., Abrus precatorius Linn., Camellia sinensis (L.) Kuntze., Psidium guajava L., Kaempferia galanga Linn., Aloe vera, Curcuma longa and Citrus hystrix DC. The most parameters used in the studies are clinical trials and in vitro tests.
Balkan Journal of Dental Medicine, 2014
The aim of this study was to evaluate the effectiveness of a new medicinal plant extract (Ankaferd Blood Stopper®, ABS) on the healing process of aphthous ulcers. A total of 50 patients with recurrent aphthous stomatitis (RAS) who have had currently a single oral ulcer in the mouth were included in the study. Patients were randomly divided in 2 groups: ABS group and Kenacort group (triamcinolone acetonid). Data were collected by questionnaire regarding age, gender, RAS history including the number of ulcer episodes in 1 month, the number of ulcers in each episode, mean healing time of previous ulcers and the mean disease duration. Ulcer size, ulcer related pain, evaluated by VAS and effectiveness index (EI), was noted in each clinical examination.In the present study, no significant differences were seen in demographic and RAS related data between the 2 groups. In ABS and Kenacort group, the mean ulcer size and VAS scores were statistically reduced at day 3 and day 7 compared to bas...
International Journal of Applied Pharmaceutics
The objective was to describe and recommend the most effective combination of Natural-Based Product (NBP) and mucoadhesive for Recurrent Aphthous Stomatitis (RAS) treatment. This systematic review writing was based on PRISMA guidelines. The articles published in the last 10 y were selected using PubMed and Google Scholar database carried out during May 2021. The keywords were: natural-based product, mucoadhesive, and Recurrent Aphthous Stomatitis. The risk of bias was assessed using the Oxford Quality Scoring System. Six articles of Randomized Controlled Trial were selected. The NBP were: Aloe vera, Myrrh, Curcuma longa, propolis, ginger, Punica granatum flower, and sesame oil. The drug’s formulation was: gel, film, and spray. The mucoadhesive polymers as vehicles were Hydroxy Propyl Ethyl Cellulose (HPEC), Hydroxy Propyl Methylcellulose (HPMC), Benzocaine, Tragacanth Gum, Carbomer 934, Sodium CMC (carboxymethyl cellulose), and chitosan. Curcuma longa 10 mg/g with HPMC was the most ...
Background: Diabetes Mellitus (DM) is a disease that can be known by increasing a blood glucose level and caused many kinds of complications if it don't properly treatment, one of those complications is a diabetic ulcer. There are many types of treatments created to overcome the diabetic ulcer, but there are not effective yet. Therefore, ethanolic extract gel of binahong (Anredera cordifolia (Tenore) Steen) leaves is used to make a new innovation of diabetic ulcer treatment Objective: The objective of this research wasto know the concentration of antibacterial and anti-infection activity from ethanolic extract of binahong leaves as wound healing on diabetic ulcer and also to know the changeover of wound diameter. Methods: Binahong leaves were extracted with 96% ethanol by maceration. Then the extract was formulated to be gel product with the concentration of 10% and 30%. The gel product was administrated to diabetic rats which had been made ulcer wound by excision. The result of wound diameter and the percentage of wound healing were analyzed by One Way Anova and then continue analyzed by LSD (Least Significant Different) with significant level of 95%. Results: The result showed that binahong gel with concentration variation of 10% and 30% only affected the organoleptic and doesn't affect the homogeneity, pH, irritation, spreadability and consistency. The result of the effectiveness test of binahong leaves gel is 10% more effective to changeover of wound diameter but there is not significantlydifferent if compared with 30% gel of binahong leaves. Therefore, gel of binahong leavesof 10% is able to provide slightly effective than chloramphenicol TM . Conclusion: The concentration of 10% and 30% of binahong gel were effectively usage for wound healing diabetic ulcer in rats Latar belakang: Diabetes melitus merupakan suatu penyakit yang ditandai dengan meningkatnya kadar gula darah yang apabila tidak ditangani dengan baik akan menimbulkan berbagai komplikasi, salah satunya ulkus diabetik. Sudah banyak jenis pengobatan yang dilakukan untuk mengatasi ulkus diabetik, tetapi belum ada yang efektif. Oleh sebab itu dicari inovasi pengobatan baru dengan menggunakan gel ekstrak etanol daun binahong (Anredera cordifolia (Tenore) Steen). Tujuan : Tujuan penelitian ini adalah mengetahui konsentrasi yang tepat terhadap aktivitas antibakteri JKKI 2016;7(5):227-236
Proceedings of the 1st International Conference in One Health (ICOH 2017), 2018
Anredera cordifolia (Ten.) Steenis, in Indonesian is binahong, is a creeping plant with a length can reach 6 meters. Binahong originated from the United Stated and be classified in Family Basellaceae. In Indonesia, binahong often be used for traditional medicines to treat diabetes, relieve shortness of breath, stabilize blood pressure, coughing and vomiting blood, lung disease, accelerate wound healing process, restoring bruised, headache, hives, immune system, nose bleeding, prevent stokes and health problems after the surgery and childbirth. Binahong contains several active compounds, such as saponins, alkaloids, polyphenols, flavonoids, and glycosides that have an effect on the wound healing process. The extract of binahong leaf is made to retain the active compound content which is inside the leaf binahong in order to still have effect as anti-inflammatory, antioxidant, antibacterial, and as an analgesic. The purpose of this review is to educate the public about the benefits of leaves binahong and examine some researches related to the effects of leaf binahong on the health of livestock. Several studies have been conducted to prove that the leaf extract binahong positively influence on the process of wound healing in a rabbit uterine post partum; wound healing Staphylococcus aureus infection in mice; reduction of surface area burns Sprague Dawley rats; re-epithelialization of the epidermis in burns Sprague Dawley rats; accelerate the healing of cuts in the duration of swiss Webster male mice; test the effectiveness of binahong leaf extract ointment (Anredera cordifolia (Ten.) Steenis) in rabbits (Oryctolagus cuniculus) were infected with the bacteria staphylococcus aureus. The conclusion of this review article is binahong leaf extract can accelerate the wound healing process in animals that can be potentially as a treatment alternative.
Journal of Dentomaxillofacial Science, 2016
Objective: To compare the effects of platelet-rich fibrin (PRF) and connective tissue graft (CTG) in gingival recession treatment using coronally advanced flap (CAF) Methods: Electronic Pubmed, Wiley, and EMBASE searches were conducted to identify articles published in dental journals without any restrictions of publication date. Gingival Recession Depth (RD), Keratinized Tissue Width (KTW), Probing Depth (PD), Clinical Attachment Level (CAL) and % Complete Root Coverage (CRC) were evaluated at baseline and 6 months. Patients with discomfort postsurgery was measured by comparing Visual Analog Scale (VAS) scores. Manual searches of human clinical trial and related articles were performed afterward. There are 31 studies explained about this, but only 6 studies met the inclusion criteria. Results: The initial database search produced 221 titles. All articles were selected for full-text review. Six studies were selected for inclusion, with 88 patients as subjects. Most of the studies showed the decreased of RD, PD, CAL and the increased of KTW in both techniques at baseline and 6 months follow up. The percentage of CRC showed higher in CTG rather than PRF whereas VAS score showed lower in PRF group Conclusion: Both PRF + CAF and CTG + CAF techniques are effective procedures in the treatment of gingival recession. The combination of CAF+CTG achieved a better result in root coverage however, PRF avoids a donor site, which means a major decrease in postoperative discomfort.
2019
Anredera cordifolia (Ten.) Steenis, also known as Binahong, is a family of Basellaceae, a medicinal plant that had been growing well for many years. Binahong leaf extract can stimulate fibroblast and collagen formation which will accelerate the process of wound healing. This study was carried out to observe the proliferation kinetics and migratory activity of 3T3 fibroblast cell lines induced by Anredera cordifolia (Ten.) Steenis ethanol extract. Anredera cordifolia (Ten.) Steenis powder was extracted by maceration with 70% ethanol. Proliferation activity was assessed by using the MTT assay. Cell migration activity was determined using scratch assay. The data obtained were analyzed statistically with data analysis, descriptive analysis, and continued with the bivariate analysis of correlation between case groups. The results of phytochemical analysis test on the content of Binahong leaf extract’s secondary metabolites confirmed the presence of saponins, tannins, alkaloids, triterpen...
Caspian journal of internal medicine, 2015
Recurrent aphthous stomatitis (RAS) is the most common oral mucosal lesions in the general population. Various treatment modalities have been used; but no specific therapy proved to be definitive. Ginger Officinale (ginger) indicated to have anti-inflammatory properties in herbal medicine. Thus, this study aimed to evaluate the efficacy of ginger containing bioadhesive in the treatment of aphthous ulcers. In this randomized double-blind placebo-controlled trial, 15 patients were enrolled. The clinical efficacy of the mucoadhessive on pain, inflammatory zone and ulcer's diameter in the test period was compared with that of the base treatment and no treatment periods during 10 days of study. Significant reduction in pain was observed on day 5 between placebo (using base bioadhesives) and without treatment periods at the first phase of the study (4.53 vs. 3.27; P=0.038. ( Reduction in inflamed halo diameters was significant on day 1 between without treatment and ginger containing bi...