A nodular hyperplasia of the thymic epithelium (so-called microscopic thymoma) (original) (raw)
Related papers
Microscopic thymoma and myasthenia gravis
Journal of Clinical Pathology, 1995
A rare case of microscopically sized thymoma is described in a 56 year old man suffering from myasthenia gravis. Histological examination of the surgically removed thymus showed the presence of several epithelial thymoma-like islands. As controls, 100 thymuses obtained from consecutive necropsies were sampled: 4% of these cases showed epithelial islands. This case is further proof that "microscopic thymoma" is a true pathological entity and suggests that every thymus removed from myasthenic patients in which there is no macroscopic evidence of thymoma should be examined microscopically on serial sections. (J7 Clin Pathol 1995;48:682-683)
Thymic Epithelial Tumors a Six Year Study
University Journal of Pre and Paraclinical Sciences, 2016
Thymic epithelial tumours are rare with incidence of 3.2 per 1,000,000. The spectrum of epithelial tumours comprises thymoma, invasive thymoma and thymic carcinoma. In our Institute we conducted a retrospective study on thymic epithelial tumours for a period of 6 years from January 2007 to December 2012. The clinical details, age and sex predilection, association with myasthenia gravis, gross and microscopic findings were analysed. A total of 40 cases were reported of which 30 were thymomas, 5 were invasive thymomas and 5 were thymic carcinomas.
Updates in CT characterization of thymic epithelial tumors in patients with myasthenia gravis
Journal of Medicine and Life, 2012
Thymic epithelial tumors have been traditionally classified into two main types: noninvasive and invasive thymoma. Several classifications have been proposed for thymic tumors, but according to these classifications, the prognosis of patients with thymomas varies considerably. Our purpose is to present different CT aspects according to various subtypes of thymic epithelial neoplasms based on the simplified World Health Organization classification. In this article, we will discuss and illustrate histologic and functional features of the thymus and a spectrum of thymic tumors associated with Myasthenia Gravis. Smooth contours and a round shape are the most suggestive of type A thymic epithelial tumors, whereas irregular contours and heterogeneous enhancement are the most suggestive of type C tumors. Calcifications are suggestive of type B tumors. CT findings may serve as predictors of postoperative recurrence or metastasis for the thymic epithelial tumors.
Archive of Oncology, 2017
Background. Thymomas are rare neoplasms arising from tissue elements of the thymus. The objective of the study was to analyse clinical characteristics of patients with thymoma, as well as morphological and patohistological features of neoplasms. Methods: Retrospectively we studied 41 medical records and patohistological material of patients reffered to the Institute for pulmonary diseases of Vojvodina between the January 2005 and December 2014. Results: Patient age at presentation ranged from 19 to 77 years. A slight female preponderance was detected, with 24 (58.5%) females and 17 (41.5%) males being affected. All types of thymoma more often occured in males, accept subtype B1. Patients with type A thymoma and subtype B1 were mainly asymptomatic, while patients with subtype B2 and type presented with dyspnea, dysphagia, pain and cough. Myasthenia gravis often was associated with type A (40%). The most common histologic type was subtype B1. Twenty three (56%) patients had a tumor di...
Thymus and thymoma: what's new?
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
The thymus is the prototype of lymphoid and epithelial organ that consists of lymphoid and epithelial cells. In spite of remarkable progresses made in the field of the immunohistochemical characterisation of the thymus parenchyma, the diagnosis of thymoma largely depends on the interpretation of conventional morphologic aspects. Histogenesis of this organ is a multi-step process, and many stages reproduce lesions and changes found in the adult thymus. The normal structure and its variants are extremely helpful to differentiate normal from pathologic aspects. Particular aspects of the thymus structures were shown in myasthenia gravis, despite the behaviour of thymoma in these patients is not clearly understood. Authors performed a detailed description of the conventional pathology of the thymoma, based on the new classifications, recently adopted. The immunohistochemical profile could be helpful in the diagnosis of many cases, and also seems to be useful in prediction of invasion tha...
Indian Journal of Surgical Oncology, 2013
Thymic tumors represent 0.2-1.5 % of all malignancies with an incidence of 0.15 per 100,000 population. Thymic tumors are most common tumors of the anterior mediastinum accounting for 20 % of all mediastinal tumors and 50 % of all anterior mediastinal tumors. Over 90 % of all thymic tumors occur in anterior mediastinum, remainder occurring in neck or other mediastinal areas especially aortopulmonary window and retro cardiac area which are common sites for ectopic thymic tissues and possible explanation for failure in some cases of simple thymectomy to improve Myasthenia Gravis(MG). The aim of this review is to discuss histologic classification, diagnostic features, evaluation, management and prognosis of thymic tumors.
Clinico-Pathological Analysis of Thymic Epithelial TumoursAn Institutional Study
Annals of Pathology and Laboratory Medicine
Background: Thymic epithelial tumours are anterior mediastinal neoplasms and they exhibit a spectrum of histomorphological features. Methods: In this study we analysed the clinico-pathological spectrum of thymic epithelial tumors at our institution. It is a retrospective and descriptive study done at our Department of Pathology, Amala Institute of Medical Sciences, Thrissur, Kerala over a period of ten years from August 2008 to August 2018. Histological sections of each case were meticulously analysed. Immunohistochemistry was done if needed. Result: In this study 17 cases of thymic epithelial tumors were analysed. A male preponderance of 58.8% was observed. Age ranged from 24 to 73 years with a mean age range of 54.4 years. Most common histological subtype of thymoma was Type B and Type AB. 4 cases were associated with myasthenia gravis. Masaoka Stage I was commonly observed. Conclusion: Thymic epithelial tumors are a unique group of anterior mediastinal neoplasms which also pose a diagnostic challenge. This study highlights the significance of clinico-pathological correlation and staging of thymic neoplasms.
Invasive medullary thymoma associated with myasthenia gravis: an unusual case
Arquivos de Neuro-Psiquiatria, 2000
Thymomas are tumors characterized by a remarkable morphological heterogeneity and variable clinical behavior. This tumor has unique clinical associations, most notably with hematological abnormalities and myasthenia gravis. According with the Müller-Hermelink criteria, there are significant differences between the histological types of thymomas and the association with myasthenia gravis. Among the different histological types, medullary thymoma is the least frequent variant associated with this autoimmune disease. In this report we describe a case of medullary thymoma presenting in a 71-year-old woman with a myasthenic syndrome.
Journal of Medical Science And clinical Research, 2017
Myasthenia gravis (MG) is associated with multiple variants of invasive thymomas which have been reported in literature. Unfortunately there is no clear histologic distinction exists between benign and malignant thymomas. These cases if not diagnosed properly may present in later stages with a turbulent course and prognosis. Invasive thymomas were correlated with a higher probability of recurrence. Good outcome can be obtained if early and definitive diagnosis of capsular invasion has been made during histopathological examination (HPE). The consensus is that patients with invasive thymoma, should receive neo-adjuvant therapy for better outcome. We encountered a rare type of invasive thymoma in which thymic cells were infiltrating through the capsule into pericapsular adipose tissue. This type of capsular invasion maybe considered potentially curable, if diagnosed early and can guide clinicians in deciding neo-adjuvant therapy after radical surgery.