Glucose levels in the vitreous in patients with retinal detachment (original) (raw)

Acta Ophthalmologica, 2014

Abstract

ABSTRACT Purpose In retinal detachment surgery when primary vitrectomy is performed , macular atrophy limits visual recovery. The physiopathological mechanism of this macular impairment remains unknown. The purpose of the present study is to evaluate whether the vitreous composition could be a prognostic factor for visual outcome and macular atrophy.Methods In a prospective study on 51 non diabetic patients undergoing primary vitrectomy for rhegmateous retinal detachment, a biochemical analysis of Na,K, Cl, glucose was performed . Post-operative visual acuity and macular thickness assessed with OCT was correlated with the biochemical analysis.Results In the group with low glucose levels, macular thickness was higher than in the patients with higher glucose levels (p=0.0002 Mann-Whitney). No difference in terms of post-operative visual acuity was found between the 2 groups with high and low glucose levels in the vitreous. Na, K, Cl appeared to have no incidence on macular thickness or post operative visual acuity.Conclusion Increased glucose levels appear to be assocated with macular atrophy. They may be reflect retinal glycation even in non diabetic patients.

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