The Etiology and Clinical Evaluations of Neonatal Seizures in Kashan, IRAN (original) (raw)
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Iranian journal of child neurology, 2014
Seizures in neonates are very different from those of older children and adults. The aim of this study was to determine the etiology, clinical presentation, and outcome of seizures in hospitalized neonates of Besat Hospital, Hamadan, Iran. In this retrospective study, we evaluated all neonates with seizures (aged 0-28 days) admitted to the Besat hospital, Hamadan, over a period of three years from September 2008 to September 2011. The data were obtained from hospital records and analyzed using SPSS 12. Seizures were reported in 102/1112 (9.1%) neonatal admissions. Among neonates with seizures, 57% were male and 23.5% were preterm. The mean birth weight was 2936±677 grams and the mean gestational age was 37.60±1.94 weeks. 16.7% of them were LBW and 2.9% VLBW. In terms of seizure type, subtle seizures were observed in 38.2%, tonic in 29.4%, clonic in 26.4%, and myoclonic in 5.9% of cases. The main diagnosis in neonates with seizures included hypoxic-ischemic encephalopathy (HIE) (34.3...
2021
Introduction: The incidence of neonatal seizures has been reported at 1.8 to 8.6 in 1,000 live births. It seems that the brain of premature children is more susceptible to seizures. The causes of neonatal seizures comprise a range of neurological disorders, including hypoxic-ischemic encephalopathy (HIE), central nervous system infection, intracranial hemorrhage, and structural disorder of the brain. Among all, the most common cause is HIE. Given the risks and consequences of neonatal seizures, this study aimed to investigate their risk factors. Methods: This is a descriptive cross-sectional study of 92 neonates, aged < 28 days, admitted to Neonatal Intensive Care Unit (NICU) during the period from March 2011 to May 2014, with the diagnosis of seizures. Demographic data including age, sex, gestational age, birth weight, fifth minute Apgar score were extracted from patient files. Data were analyzed using SPSS® version 19 software. Results: Of 92 cases, 12 (13.0%) had the fifth min...
The Etiologic Profile of the Pediatric Seizure: An Epidemiological Study from Iran
International Clinical Neuroscience Journal, 2017
Background: Seizures are one of the most common neurologic disorders in children. The aim of this study is to determine the main etiologies of seizure in children. Methods: Children with a complaint of seizure in Loghman Hakim hospital, from June 2014 to January 2016 were evaluated. The final diagnosis of seizure was made by a pediatric neurologist. The age, sex, type of seizure, associated fever, history of head trauma and other variables related to seizure in pediatric group were reviewed from the medical records. Results: A total of 200 children with a diagnosis of seizures were included in this study. A total of 59% were male patients. The age of the patients ranged from 3 months to 102 months with a mean of 23 months.About one-quarter of the patients had focal seizures while others had generalized seizures. Sixteen patients (8%) had a positive family history of epilepsy. Of total 126 patients (63%) experienced their first lifetime seizure. The body temperature of the patients r...
International Surgery Journal, 2020
Neonatal seizures are the primary and most important signs of neural function disorders that often lead to serious neural complications. However, these disorders are predictable and manageable with suitable diagnostic and therapeutic methods. If left untreated, neonatal seizures can cause irreversible damage to the neural system and put neonates at risk of death. Furthermore, those that survive would be at risk of epilepsy, and neurological and developmental disorders. 1 Seizures are categorized as attack disorders meaning that it leads to sudden and reversible changes in the mental status and somatosensory performance of the individual. They have a repetitive nature and last from several seconds to several minutes, end quickly and return to the natural status gradually. Seizures that originate from a cerebrovascular region are called localized and those originating simultaneously from both lobes are called generalized seizures. Seizures can be categorized generalized categories including absence, tonic, clonic, petit-mal, myoclonic, atonic, and focal or partial seizures. 2 Neonatal seizures are clinically referred to the abnormal and repetitive changes that occur in the brain function in ABSTRACT Background: Neonatal seizures are the primary and most important signs of neurologic function disorders that often lead to serious complications. However, this disorder is predictable and manageable with suitable diagnostic and therapeutic methods. The aim of this study was to investigate the frequency, causes, and findings of brain CT scans of neonatal seizure. Methods: This descriptive cross-sectional study has been done on 70 neonates with seizures who hospitalized in Ardabil city hospital during 2016-2017. CT scans were done for all patients. Necessary information for each patient was recorded in a checklist including demographic data, history of diabetes mellitus, hypertension, and maternal endocrine disorders, and history of resuscitation and clinical data including type of seizure and its duration, Cause of seizure and CT scan findings (cerebral hemorrhage, local ischemic lesions, hypoxemic-ischemic encephalopathy, and anatomical cerebral malformations). Results: The mean age of neonates was 12.41±9.33 days. Of them, 61.4% were boys, 3.24% LBW and 40% were preterm at birth time. Of all neonates, 21.4% had history of seizure in their relative degree family members. Fever was the most common symptom accompanying seizures (40%). The most common form was tonic seizure (n=30, 42.9%) and its duration time was 4.99 minute. A total of 41.4% of neonates (29 cases) had abnormal CT scan reports. Hypoxic-ischemic encephalopathy (47%) was the most common findings in the CT scans of neonates with seizures. Conclusions: Results showed that, a considerable number of neonates had abnormal CT findings and the most common abnormal form was hypoxemic-ischemic encephalopathy.
STUDY OF CLINICAL AND ETIOLOGICAL PROFILE OF NEONATAL SEIZURES IN TERTIARY CARE HOSPITAL
National Journal of Medical Research, 2023
Introduction: Neonatal seizure is defined as paroxysmal electrical discharge from the brain. The immature brain seems more prone to seizures. The incidence was found to increase with decreasing gestation and birth weight- preterm neonates (20.8 vs. 8.4 per 1000 live-births) while very low birth weight neonates had more than 4-fold higher incidence (36.1 per 1000 live-births). Objective: The study was conducted to estimate the incidence, etiological factor, time of onset, clinical types, and biochemical abnormalities among the different types of neonatal seizures. Methods: This is a hospital based prospective observational study conducted in NICU, Department of Pediatrics, SMIMER during the period of January 2020 to March 2021. Results: Total patients with neonatal seizures were 90 in our study. Inci-dence of neonatal seizures in our study was 1.1%. Incidence was higher in preterm neonates (4.8%) and more in males (56.67%). Incidence of neonatal seizures was higher in LBW babies (4.3%) and more common in SGA babies (51.11%). Incidence among vaginal delivered babies was 0.9%, LSCS was 1.7% and forceps was 1.1%. Birth asphyxia (41.1%) was the most common cause of all neonatal seizures followed by hypoglycemia (17.8%), neonatal meningitis/septicemia (14.5%), hypocalcemia (12.2%), ICH (7.8%). Subtle seizures (44.4%) were the commonest type of seizure followed by tonic (38.9%), focal clonic (11.1%), multifocal clonic (5.6%). 33.3% of neonatal seizures occurred in < 24hrs & 40% in 24-72 hrs. The most common biochemical abnormality was hypoglycemia (17.8%) followed by hypocalcemia (12.2%). Conclusion: Incidence of neonatal seizures was 11.1/1000 live births (1.1%) & more common in preterm, LBW & LSCS deliveries. Birth asphyxia was the most common cause and subtle seizures were the most common type of seizure. Subtle seizures were more common in 24-72 hours of life. Most common biochemical abnormality was hypoglycemia followed by hypocalcemia.
Research Article Neonatal Seizure: Etiology and Type
2007
Objective for many reasons, are at particular risk for the development of seizures, which are a strong predictor of later morbidity and mortality in infants. this study to determine the incidence, etiologic distribution and neonatal seizure type in neonates with hospital admission over a period of 4 years. Materials and Methods This, a retrospective study of newborns admitted in hospital with a diagnosis of neonatal seizures, was conducted over a 4 year period between March 2001 and March 2005. Data were obtained from hospital records was analyzed using the Chi-square test. Results4541 newborns, admitted to hospital, during the study period, seizures occurred in 110 neonates. The incidence of neonatal seizures was 2.4%; the causes of neonatal seizure were Hypoxic-Ischemic Encephalopathy (HIE) - 36.4%, infections -19.1%, metabolic abnormalities - 7.3%, Intra Cranial Hemorrhage (ICH) - 2.7%, structural disorders - 1.8% and in 32.7% of cases, the cause was unknown. Subtle seizures (39....
2018
Objective: Neonatal seizures are common, difficult to diagnose and treat, and associated with a great mortality rate and long-term risk of neurodevelopmental impairments. We aimed to determine the etiology, clinical presentation, and neurodevelopmental outcome of neonatal seizures. Materials and Methods: In this cross-sectional study, 88 neonates, aged < 28 days, admitted to Mofid Children’s Hospital, Tehran, Iran, from September 2011 to 2013 with the initial diagnosis of seizure were enrolled by convenient sampling method. Data, including age, gestational age, birth weight, Apgar of the fifth minute, neonatal intensive care unit (NICU) admission, family history, type, cause, and age of seizure, EEG and paraclinic findings, anticonvulsant used for treatment, neurodevelopmental status, and the final outcome, were collected from medical records and the missed cases were completed by phone calls. The frequency and association of variables were analyzed using SPSS software. Results: ...
Neonatal seizures, experience at Children Hospital and Institute of Child Health Multan
Pakistan Journal of Medical Sciences, 2013
The study was conducted to determine the etiology of seizures in neonates. Methods: This was a descriptive Cross-sectional study. This study was conducted at neonatal unit of children hospital and institute of child health Multan from June 2012 to April 2013. A total of 285 neonates who presented with seizures were enrolled for the possible causes. First line investigations including blood glucose, serum calcium, serum magnesium, serum sodium, complete blood counts, serum creatinine, liver function tests, ABGs, cerebrospinal fluid examination, cranial ultrasound and EEG were done in all neonates. Second line investigations (blood culture, CT scan, MRI, screening for inborn error of metabolism and Torch antibody titer) were done in selected neonates. The data was analyzed using SPSS-10. Results: Out of 285 neonates, 175(61.4%) were male and 110(38.6%) female. There were 199(69.8%) term and 86 (30.2%) preterm. Birth asphyxia was the commonest cause of seizures and present in 53.7% neonates and metabolic disturbance in 17.5%. Seizures with unknown etiology were present in 5.3% neonates. Conclusion: In most of the cases, the causes of neonatal seizures were present. Birth asphyxia was the main etiology identified. However, to establish the exact cause of seizures, more extensive work up is needed.
Neonatal seizure and short-term outcomes in hospitalized neonates
Caspian journal of pediatrics, 2018
Background: Neonatal seizure is a common problem and associated with a great mortality rate, high risk of chronic neurodevelopmental impairments, also difficult to diagnosis and treatment. The aim of this study was to determine the neurodevelopmental outcome, clinical presentation and etiology of seizures in neonates admitted to Amirkola Children's Hospital (ACH). Methods: In this cross-sectional study, 42 neonates with the initial diagnosis of seizure, aged less than 28 days, hospitalized in ACH, northern Iran, from April to September 2016 were selected using convenient sampling method. The patients' information was gathered during hospitalization period and 6 months after discharge. Data were analyzed using SPSS 22 through descriptive and chi-square tests. Results: Among preterm and term neonates with seizures, the main diagnosis in neonates with seizures was idiopathic (38.1%) and hypoxic-ischemic encephalopathy (HIE) (14.3%), hypoglycemia (9.5 %) hypomagnesaemia (7.1%) a...
Clinicoetiological Profile of Neonatal Seizures in a Tertiary Care Hospital
Indian Journal of Child Health, 2017
eizures in newborns are qualitatively different from those in older children and adults because of anatomical as well as physiological immaturity of the central nervous system. The international classification of epileptic seizures does not apply to newborn seizures because neonates are unstable to sustain organized discharges and do not manifest generalized tonic-clonic seizures and any abnormal, repetitive, and stereotypic behavior in neonates also needs to be evaluated as possible seizure [1]. Neonates are at particular risk for the development of seizures, because metabolic, toxic, structural, and infectious diseases manifest more during this time than in any other period of life [2]. The National Neonatology Perinatal Database of National Neonatology Forum of India for year 2002-2003 recorded a seizure frequency of 1.03% [3]. Seizure incidence has been reported to be 57.5 per 1000 in babies with birth weight <1500 g. Incidence markedly decreased to 2.8 per 1000 in babies weighing between 2500 and 3999 g. The reported frequency in international studies (Eghbalian et al. [4] and Scher et al. [5]) is above 2%. Such variability in reports is not surprising if we take into account the population studiedpreterm versus term babies, the magnitude of the problem of birth asphyxia which is a sensitive indicator of perinatal seizures in a unit and criteria used for diagnosis of seizures-clinical only or clinical with electroencephalogram (EEG) as well. Further with improvement in perinatal care many a conditions causing seizures in neonates may be prevented; thus, a temporal change with reduction in frequency of seizures over a period of time is not surprising (1.03% in 2002 vs. 0.77% in 2013). Among conditions which present as seizures, hypoxic ischemic encephalopathy (HIE) has been the most common cause of seizures in most Indian studies followed by hypoglycemia, hypocalcemia, infections, intracranial hemorrhage (ICH), bilirubin encephalopathy, etc., which have different frequency in different studies [6-8]. Etiology of seizures, to some extent, depends on the age of the baby at the time of onset of seizures [9]. The aim of this study was to determine the clinicoetiologic association of seizures in neonates for more precise and prompt diagnosis and treatment.