Co-Implantation of Primary Chondrocytes with Bone marrow Mesenchymal Stem Cells in a nude mouse model; Towards an Interoperative Cell Therapy for Cartilage repair (original) (raw)

Abstract

A source of cells with chondrogenic potential for clinical application is mesenchymal stem cells (MSCs) from bone marrow (1,2). Differentiation of multipotent MSCs is in general initiated at high-cell density in 3-D with a combination of chondrogenic growth factors (3,4). We examined the potential of primary articular chondrocytes (PACs) to enhance matrix production when mixed with MSCs at different ratios in vitro in a pellet model and in vivo as seeded onto 3D-printed PEGT/PBT block co-polymer scaffolds, in a nude mouse model. Results described here demonstrate that co-culturing in vitro or co–implantation in vivo of primary chondrocytes with mesenchymal stem cells enhances cartilage specific matrix production.

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