Phytochemical and Antioxidant Studies on Methanolic Extract of Gmelina asiatica Linn Stem (original) (raw)

International Journal of Pharmacognosy and Phytochemical Research

Abstract

To evaluate the phytochemical constituents and antioxidant activities of methanolic extract of Gmelina asiatica stem which is locally used for the treatment of various diseases. The antioxidant and free radical scavenging activity of methanolic extract of the plant was assessed against 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), the ferric reducing agent. Total phenolics, flavonoids were also determined to assess their corresponding effect on the antioxidant activity of this plant. Phytochemical analysis revealed the presence of tannin, alkaloid, steroids, glycosides and saponins. The results exhibited a positive linear correlation between these polyphenols and the free radical scavenging activities. The activities of plant extract against DPPH, NO radicals were concentration dependent with IC50 value of 18.38 and 78.18μg/mL respectively. The reducing power of the extract was 84.15 μg/mL. The total phenolics content of the methanolic extract of stem was 4800±24.53 and t...

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