Aloe ferox Research Papers - Academia.edu (original) (raw)

2024, African Journal of Biotechnology

Volatile compounds oils play a significant role in perfumery, cosmetic, medicinal and pharmaceutical industries. In our protracted research for new useful essential oils, a volatile oil from Aloe ferox was obtained by prolonged hydrodistillation. This volatile oil was subjected to GC/MS analysis to identify the major constituents of the oil. The major constituents identified were as follows: 3, 6 octatriene (23.86%), 3-cyclohexane-1-hetanol (7.31%), Bornylene (5.24%), 1, 3-cyclopentadiene (4.07) and 5-methyl- 3-heptanol (3.92%). A significant number of other volatiles were also identified but in minor concentrations.

2024, Journal of Ethnopharmacology

In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species,

2024, Skin Pharmacology and Physiology

tigue area F3, which is known to decrease with age and fatigue, also increased with Aloe sterol intake. Ultrasound echogenicity revealed that the collagen content in the dermis increased with Aloe sterol intake. Conclusion: The results... more

2023, Skin Research and Technology

Background/purpose: The polysaccharide-rich composition of Aloe vera extracts (Aloe barbadensis Miller), often used in cosmetic formulations, may impart moisturizing properties to the product. The aim of this study was to evaluate the effect of cosmetic formulations containing different concentrations of freeze-dried Aloe vera extract on skin hydration, after a single and a 1-and 2-week period of application, by using skin bioengineering techniques. Methods: Stable formulations containing 5% (w/w) of a trilaureth-4 phosphate-based blend were supplemented with 0.10%, 0.25% or 0.50% (w/w) of freeze-dried Aloe vera extract and applied to the volar forearm of 20 female subjects. Skin conditions in terms of the water content of the stratum corneum and of transepidermal water loss (TEWL) (Corneometer TM CM 825 and Tewameter TM TM 210) were analysed before and after a single and 1-and 2-week period of daily application. Results: After a single application, only formulations supplemented with 0.25% and 0.50% (w/w) of Aloe vera extract increased the water content of the stratum corneum, while after the 2-week period application, all formulations containing the extract (0.10%, 0.25% and 0.50%) had the same effect, in both cases as compared with the vehicle. TEWL was not modified after a single and after 1-and 2-week period of application, when compared with the vehicle. Conclusion: Our results show that freeze-dried Aloe vera extract is a natural effective ingredient for improving skin hydration, possibly through a humectant mechanism. Consequently, it may be used in moisturizing cosmetic formulations and also as a complement in the treatment of dry skin.

2023, Clinical Nutrition

Background: The EU-supported ATHENA project stems from a previous study suggesting that moderate wine consumption reduced the side-effects of radiotherapy (RT) in breast cancer patients, an effect possibly due to non-alcoholic anthocyanin fractions of wine. Objective: To evaluate the role of anthocyanins on RT skin side effects in breast cancer patients. Methods: Randomized, controlled, double-blind clinical trial. Patients were assigned to an intensity modulated radiation therapy (IMRT) either for three or five weeks, then randomized to receive three times a day a water-soluble anthocyanin (125 mg)-rich extract of corn cob or a placebo. Supplementation started one week before till the end of RT. Skin characteristics were detected by a standardized, noninvasive Cutometer® dual-MPA580, providing quantitative indices of skin maximal distensibility (R0), elasticity (R2, R5, R7) and viscoelasticity (R6); a Mexameter® MX18 probe evaluated the skin erythema (Er) and melanin (M). Measures were performed before (T0), at the end of RT and of supplementation (T1), and 1, 6 and 12 months after RT (T2-T4). Acute and late skin toxicity were scored according to the RTOG/EORTG scale. Selected biomarkers were measured at T0 and T1. Results: 193 patients previously assigned to 3-or 5-week RT schedules were randomized to either anthocyanin (97) or placebo (96) supplementation. RT induced changes in skin parameters: R0, R2, R5 and R7 decreased, while R6 increased; the changes in R0 and R6 continued in the same direction up to one year, while the others recovered towards basal values; Er and M peaked at T1 and T2, respectively, and returned to basal values at T4. Comparable skin changes were apparent in anthocyanin and placebo groups. A moderate RT-induced increase in total and HDL cholesterol and triglycerides was prevented by anthocyanins. Conclusions: Anthocyanin supplementation did not prevent RT-induced local skin toxicity. The supplementation was well tolerated and safe.

2022, Natural Product Communications

A new naphthalene O,O,O-triglycoside, kenyaloside (1), was isolated from the dried exudate of Kenyan Aloe species, a bittering and laxative agent. Its structure was established by combined spectral and chemical methods as... more

2022, Journal of Young Pharmacists

Objective: To look for antioxidant, lightening and anti aging effects from combination of Indonesian plant consist of Centella asiatica, Camellia sinensis and Glycine max extract in propanediol (CCGE). Methodology: The study was carried out using DPPH scavenging activity for antioxidant effect and anti tyrosinase activity for lightening effect. The efficacy test on volunteers was performed using Mexameter MX 16 and Cutometer MPA 580 to measure skin melanin index, elasticity and firmness respectively. The dermatological safety test was conducted using Repeated Opened Patch Test (ROPT) and Single Closed Patch Test (SCPT), while HETCAM test was performed to evaluate irritation at ocular level. Result: At the concentration of 2%, CCGE has DPPH scavenging activity and anti tyrosinase activity of 70.56% and 52.76% respectively compared to ascorbic acid and kojic acid. The efficacy test showed that CCGE significantly increased skin elasticity and firmness after two and four weeks of application compared to base, but showed no significant effect on skin lightening. The dermatological safety test showed that CCGE did not cause any irritation or allergic skin reaction at the concentration of 5% for the ROPT and up to 3% for the SCPT. Meanwhile at the concentration of 5%, CCGE could cause allergic reaction in 4.0% of all subjects. The HETCAM test showed that CCGE is not irritant at the ocular level. Conclusion: These results concluded that CCGE is proven to be safe for human skin as well as at ocular level and could be used as cosmetic active ingredient for anti aging.

2022, Journal of Cosmetic Dermatology

Background: The epidermis is keratinized stratified squamous epithelium covered by hydro-lipid barrier. Vitamin C is a water-soluble antioxidant which protects skin from oxidative damage and rejuvenates photo-aged skin. There are different options of improving active substance penetration through the stratum corneum of the epidermis. One of them is noneedle mesotherapy which is a non-invasive rejuvenation technique involving electric pulses, electroporation, and ultrasounds. The use of these physicals factors results in deeper penetration of active ingredients. The other one is micro-needle mesotherapy which is nonsurgical therapy, which could cause the controlled inflammation. Micro channels are formed by needles during the skin puncture, that facilitate penetration of the active ingredients. Aims: The aim of the study was to assess the efficacy of L-ascorbic acid applied in combination with no-needle and micro-needle mesotherapy in anti-aging therapy. Materials and Methods: This study involved 17 healthy volunteers, 2.5 ml of serum containing 20% L-ascorbic acid with hydrate from strawberries was used topically in every of 4 treatments. No-needle mesotherapy was applied on the left half of the face while microneedle mesotherapy in combination with the same serum was performed on the right half of face. Results: In vivo studies confirmed the effectiveness of both methods. Conclusion: The impact of active substance on skin firmness and elasticity as well as the degree of hydration and skin tone was more efficient after micro-needle mesotherapy.

2022, Natural Product Communications

Aloe barbadensis Miller (Aloe Vera Linne) products have long been employed in health foods and for medical purposes. It has anti-inflammatory, antifungal, antioxidant properties, which indicates excellent potential in antiaging cosmetic and skin protection products. The objective of this study is to evaluate the antiaging efficacy of dermocosmetic formulations containing A. barbadensis extract on young and mature skin using biophysical and skin imaging techniques. Twenty healthy adult volunteers participated in the study, aged between 20 and 65. The cream formulation, with 10% (w/w) of A. barbadensis extract, and placebo, were applied to the face of the volunteers. The effects were evaluated in terms of skin hydration and barrier effect by the measurement of transepidermal water loss (TEWL), derma firmness, and elasticity. The formulation containing A. barbadensis extract significantly improves water contained in the stratum corneum, firmness, elasticity of the skin, and decreased T...

2022, Biology

The traditional use of Aloe spp. for the purpose of wound healing has a long history and is widespread internationally. Recently, a hybrid aloe plant (Aloe muth-muth) has been cultivated by cross pollination between Aloe vera and Aloe ferox. The Aloe muth-muth plant has not yet been investigated for medicinal properties and provides an opportunity for potential biological activity, including wound healing. The aim of this study was to investigate the in vitro wound healing effects of both Aloe muth-muth gel and whole leaf material with the use of the immortalized human keratinocyte (HaCaT) cell line. Cell viability was conducted using methyl thiazolyl tetrazolium (MTT) assays. In vitro wound healing was tested on HaCaT cells using an established scratch assay method. The effect of Aloe muth-muth gel material on HaCaT cell migration was also investigated. Aloe muth-muth gel material exhibited statistically significantly (p < 0.05) higher percentage wound closure compared to the co...

2022, Brazilian Journal of Pharmaceutical Sciences

Acetyl hexapeptide-3 has been used in anti-aging topical formulations aimed at improving skin appearance. However, few basic studies address its effects on epidermis and dermis, when vehiculated in topical formulations. Thus, the objective of this study was to determine the clinical efficacy of acetyl hexapeptide-3 using biophysical techniques. For this purpose, formulations with and without acetyl hexapeptide-3 were applied to the ventral forearm and the face area of forty female volunteers. Skin conditions were evaluated after 2 and 4-week long daily applications, by analyzing the stratum corneum water content and the skin mechanical properties, using three instruments, the Corneometer(r) CM 825, CutometerSEM 575 and ReviscometerRV600. All formulations tested increased the stratum corneum water content in the face region, which remained constant until the end of the study. In contrast, only formulations containing acetyl hexapeptide-3 exhibit a significant effect on mechanical pro...

2022, Brazilian Journal of Pharmaceutical Sciences

2022, Dermatologic Therapy

Green tea (GT) extracts contain polyphenols, known to be effective free radical scavengers, and other ingredients that could also provide benefits to the skin. This is a report on clinical studies using objective, noninvasive methods to evaluate the effects of cosmetic formulations containing GT. Experimental formulations were supplemented or not (vehicle) with 6% Camellia sinensis glycolic leaf extracts (GT). These formulations were applied to the forearm skin of 24 volunteers, and their effects were evaluated before and after 2 hours, 15 and 30 days according to the following parameters: stratum corneum water content, transepidermal water loss, skin viscoelastic-to-elastic ratio (Uv/Ue), and microrelief. The volunteers were instructed not to apply any formulation in an area of the forearm (control area). Experimental formulations (GT) increased skin moisture in the long-term study, indicating that GT has a prolonged moisturizing effect. The Uv/Ue was significantly enhanced after 30 days of topical application of the experimental formulation when compared with vehicle and control. After 15-30 days, skin microrelief was significantly improved due to a reduction in skin roughness. The results suggest that GT-containing cosmetic formulations have pronounced moisturizing effects and improve skin microrelief.

2022, Journal of Ethnopharmacology

2022, NUST Journal of Natural Sciences

Aloe vera is part and parcel of the Liliaceae family. This is one of 250 Aloe Barbadensis species, scientifically known as Aloe Vera. Acemannane, one of the most bioactive polysaccharides of Aloe Vera, has effects of immunity modulation, anti-cancer, anti-oxidation, bone repair, neuroprotection and promotion of intestinal health. The mucilaginous gel in the pulp of aloe vera formed by the parenchymal cells has been used for a variety of curative applications since ancient times. Aloe vera is a nutraceutical product used mostly for decades. It is available in a range of health drinks and wellness beverages, in capsules/tablets and in gels & creams externally. This article includes the bioactive components, extraction and processing of aloe vera and the prospects of tissue engineering. This article highlights important uses as a nutraceutical, medicinal, and therapeutic food potential of A. vera constituents. Aloe vera nutraceutical gel scaffolds, such as acemannan, promote biomedical...

2022

Phytochemical constituents and allelopathic effect of

2021

The aim of this work was to study skin parameters like melanin, erythema, skin hydration, and sebum score of six body sites namely volar forearm, cheek, chin, forehead, neck and post auricular skin of Asian (Indian) population with different skin colour and types to depict the formulation to be used for taking care. Initially skin colour of various volunteers was assessed by the reference of colour chart numbers and three groups each of 80 human volunteers were made. Group I was named fair which corresponded with Colour chart number 19, 20, 21; group II (medium) (22, 23, 24); group III (dark) (25, 26, 27). The measurements were taken using Mexameter (erythema and melanin), Corneometer (skin hydration) and Sebumeter (sebum score). Results depicted that facial skin had more melanin content than volar forearm; the sebum score was highest in the forehead and lowest at volar forearm, skin hydration was more in periauricular space and forehead and lowest in cheek. The volunteers of group I had high sebum and skin hydration values than group II and III. In the face, cheeks need more care and are more prone to dryness. People with darker skin, require formulations having more humectants, while people with fairer skin need to protect more from tanning and redness. Hence these studies will be helpful for deciding the criteria for type of skin and selection of formulation to people of various skin types at various body sites.

2017, Journal of Ethnopharmacology

Aim of the study: The present study aimed at determining the wound healing properties of the gel and whole-leaf materials of Aloe vera, Aloe ferox and Aloe marlothii, as well as their cytotoxic effects on normal human keratinocyte cells (HaCaT).
Materials and Methods: Nuclear magnetic resonance spectroscopy was used to chemically fingerprint the aloe gel and whole-leaf materials by identifying characteristic marker molecules of aloe gel and whole-leaf materials. An MTT assay was performed to determine the cytotoxicity of the various aloe whole-leaf and gel materials on HaCaT cells. Wound healing and in vitro cell migration were investigated with HaCaT cells by means of the CytoSelect™ assay kit.
Results: The in vitro wound healing assay suggested that all the aloe gel and whole-leaf materials examined, exhibited faster wound healing activity than the untreated control group. After 48 h, all the aloe gel and whole-leaf materials almost completely caused full wound closure, displaying 98.07% (A. marlothii whole-leaf), 98.00% (A. vera gel), 97.20% (A. marlothii gel), 96.00% (A. vera whole-leaf), 94.00% (A. ferox gel) and 81.30% (A. ferox whole-leaf) wound closure, respectively. It was noteworthy that the gel materials of all the three aloe species exhibited significantly faster (p < 0.05) wound healing actions when compared to their respective whole-leaf materials at 32 h.
Conclusion: The gel and whole-leaf materials of A. vera, A. ferox and A. marlothii have shown the ability to heal wounds at a faster rate and to a larger extent than untreated keratinocytes. The MTT assay results suggested that the gel and whole-leaf materials of all the selected Aloe species showed negligible toxicity towards the HaCaT cells.

2016, Pharmacognosy Magazine

Background: Although Aloe vera extracts have exhibited various effects on the skin, less is known about the biological activities of other aloe species on the skin. Objective: To investigate the skin hydrating and anti-erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. Methods: Aqueous solutions of the polisaccharidic fractions of the selected aloe leaf gel materials were applied to the volar forearm skin of female subjects. The hydration effect of the aloe gel materials were measured with a Corneometer® CM 825, Visioscan® VC 98 and Cutometer® dual MPA 580 after single and multiple applications. The Mexameter® MX 18 was used to determine the anti-erythema effects of the aloe material solutions on irritated skin areas. Results: The A. vera and A. marlothii gel materials hydrated the skin after a single application, whereas the A. ferox gel material showed dehydration effects compared to the placebo. After multiple applications all the aloe materials exhibited dehydration effects on the skin. Mexameter® readings showed that A. vera and A. ferox have anti-erythema activity similar to that of the positive control group (i.e. hydrocortisone gel) after 6 days of treatment. Conclusion: The polysaccharide component of the gel materials from selected aloe species has a dehydrating effect on the skin after multiple applications. Both A. vera and A. ferox gel materials showed potential to reduce erythema on the skin similar to that of hydrocortisone gel.

2016, Journal of Pharmacy and Pharmacology

Objectives: The aim of this study was to investigate the in vitro permeation enhancement effects of the gel and whole leaf materials of Aloe vera, Aloe marlothii and Aloe ferox using ketoprofen as a marker compound. Methods: The permeation studies were conducted across excised female abdominal skin in Franz diffusion cells and the delivery of ketoprofen into the stratum corneum-epidermis and epidermis-dermis layers of the skin was investigated using a tape stripping technique. Key findings: Aloe vera gel showed the highest permeation enhancing effect on ketoprofen (enhancement ratio or ER = 2.551) when compared to the control group, followed by Aloe marlothii gel (ER = 1.590) and Aloe ferox whole leaf material (ER = 1.520). Non-linear curve fitting calculations indicated that the drug permeation enhancing effect of Aloe vera gel can be attributed to an increased partitioning of the drug into the skin, while Aloe ferox whole leaf modified the diffusion characteristics of the skin for ketoprofen. The tape stripping results indicated that Aloe marlothii whole leaf delivered the highest concentration of the ketoprofen into the different skin layers. Conclusions: Of the selected aloe species investigated, Aloe vera gel material showed the highest potential as transdermal drug penetration enhancer across human skin.