Hormonal Stimulation Research Papers - Academia.edu (original) (raw)

Polycystic ovary syndrome, a common cause of infertility among women in the reproductive age, is associated with high levels of androgens. Recognizing the anti-androgenic effects of spearmint, the present study aimed to evaluate the... more

Polycystic ovary syndrome, a common cause of infertility among women in the reproductive age, is associated with high levels of androgens. Recognizing the anti-androgenic effects of spearmint, the present study aimed to evaluate the effects of its hydroalcoholic extract on the levels of luteinizing hormone, follicle-stimulating hormone, and testosterone and ovarian folliculogenesis in normal and letrozole-induced polycystic ovary syndrome rats. Female mature rats were divided into six groups (n=8 per group), as follows: Normal rats (I or Control), normal rats which received 250 mg/kg spearmint extract (II) or 500 mg/kg spearmint extract (III), and PCOS-induced rats (IV), PCOS-induced rats which received 250 mg/kg spearmint extract (V), or 500 mg/kg spearmint extract (VI). At the end of the experiment the animals were euthanized, and then mentioned parameters were evaluated. Administration of spearmint extract to PCOS rats resulted in a decrease of body weight and testosterone level, higher corpus luteum, and lower ovarian cysts and atretic follicles, compared to PCOS rats which received no spearmint. Accordingly, the spearmint can attenuate polycystic ovarian syndrome-related problems, such as a high testosterone level and ovarian cysts.

This investigation was designed to assess reproductive improvement in Barki ewes using different hormonal protocols. Seventy-five non-pregnant and non-lactating Barki ewes were randomly assigned into three equal groups (25 ewes each),... more

This investigation was designed to assess reproductive improvement in Barki ewes using different hormonal protocols. Seventy-five non-pregnant and non-lactating Barki ewes were randomly assigned into three equal groups (25 ewes each), namely G1, G2 and G3. (G1) served as control, while (G2) was treated with an intravaginal progestagen impregnated sponge for 12 days then was removed. On the ninth day, all treated ewes received an intramuscular injection of prostaglandin F2α. (G3) was also synchronized as G2, in addition to on the 10th day ewes were received an intramuscular injection of 750 IU PMSG in descending doses for three days so that the last dose was injected at the 12th day concurrently with sponges' removal. Meanwhile, on the 14th day, all ewes in G3 were received an intramuscular injection of hCG hormone (500 IU/ewe). The results showed an increase in plasma progesterone level from the first day of pregnancy and rises up to the last day before parturition. Progesterone was found to be higher in G3 (that had higher twining rate) than in G2 than in G1. Insignificant increase in estrus response was observed in groups (G2, G3) compared to G1 (100, 100 and 92%, respectively). Conception rate was significantly higher in G3 (100%) than G2 (92%) and G1 (88%). While, abortion rate was higher in G1 and surpassing G2 and G3 (9.0, 0.0 and 0.0 %, respectively). Lambing rate was significantly higher in G3 as compared to G2 and G1 groups (100, 92 and 80 %, respectively). While, weaning rate was recorded to be insignificantly higher in G2 than in G1 and G3 (100.0, 95.45 and 94.29%, respectively). It could be concluded that, hormonal manipulation using intravaginal progestagen impregnated sponge and PMSG in the presence of hCG; would be a proper way for enhancing the reproductive efficiency of Barki ewes.

Objective: The purpose of the present study was to compare the extent of variation in haematologic parameter associated with the long term use of hormonal and non hormonal contraceptives in urban population of low socio-economic... more

Objective: The purpose of the present study was to compare the
extent of variation in haematologic parameter associated with the
long term use of hormonal and non hormonal contraceptives in urban
population of low socio-economic group. Type of Study: Cross
sectional study. Setting: Clinical setting. Patients and Methods:
Fifty-four young females of age ranging from 26-32 years maintained
on Oral contraceptives (OC), Depo-medroxy progesterone (DMPA),
Norethisterone (NET-EN), Implant and non hormonal intrauterine
contraceptive device (IUCD) for at least one year were invited.
Fasting blood samples were collected for the analysis of
haematologic parameters. All the results were entered in MS-Excel
and mean ± standard deviation was calculated for each frequency.
Results: Comparision among different groups was done by
calculating percentile differences among groups. Though the result of
the study does not showed the significant differences in various
indices but the hemoglobin levels in IUCD group was found to be
significantly low as compared to hormonal contraceptives. Use of
hormonal contraceptives was associated with better haematologic
profile whereas IUCDs were found to pose risk of anemia in already
anemic population of low socio economic group. Conclusion:
Though the risk in this group of young females maintained on
contraceptives was found to be minimized because of good
monitoring but continuation of IUCDs might cause this slight
predisposition of sub clinical anemia into a well defined anemic
disease later in their lives. It is therefore recommended to use
intrauterine contraceptive devices with caution in anemic women and
such methods should be used under close monitoring.