Oral and Maxillofacial Surgery Research Papers (original) (raw)

2025, Cancer Research Journal

Osteosarcoma is a malignant mesenchymal tumor whose cancerous cells produce osteoid matrix. It is the most common primary malignant bone tumor, accounting for approximately 20% of the sarcomas, but osteosarcoma of mandible is rare only 5% of the osteosarcomas occur in the jaws and occur mainly in adult population in their later part of the life. They present various clinical and histological aspects, as well as variable disease progression and outcome. Mandibular osteosarcoma are slow growing tumors and have better prognosis compared to other site. Lung is the most common site of metastasis in osteosarcoma mainly in the long bones, in craniofascial osteosarcoma lung metastasis is a rare findings. We are presenting a case of osteosarcoma of mandible in 5 year child with aggressive initial presentation.

2025, Arquivos Internacionais de Otorrinolaringologia (Impresso)

O tumor odontogênico queratocístico é raramente encontrado em maxilla. Relato do Caso: Este artigo descreve o relato de um caso de uma paciente de 60 anos de idade, leucoderma, sexo feminino, com um crescimento assintomático na região de maxila posterior diagnosticada como tumor odontogênico queratocístico. Também é discutido o diagnóstico e a propedêutica para este tipo de lesão.

2025, Journal of Oral and Maxillofacial Surgery

2025, IOSR Journal of Dental and Medical Sciences

Periodontal dressing is a surgical dressing used post operatively to cover and protect the surface of surgical wound created by periodontal therapy.The sequelae of periodontal surgery are commonly pain, swelling, inflammation and bleeding and thus, many periodontists advocate that some form of protection should be applied over the injurious tissue so that the affected area is shielded from further insult 1 . Prior to introduction of the first periodontal pack by Dr. AW Ward in 1923 3 , surgical eradication of periodontal disease was accompanied by the undesirable sequelae like pain, hemorrhage, unsatisfactory control of granulation tissue and sloughing. fig 1 Thus, s it can be concluded that wound protection, patient's comfort and some degree of hemostasis and tissue stasis are considered to be desirable effects in dressings. Ideal requisites of periodontal dressings 9  soft, but still have enough plasticity and flexibility to facilitate its placement in the operated area and to allow proper adaptation.  set within a reasonable time.  sufficient rigidity to prevent fracture and dislocation.  smooth surface after setting to prevent irritation to the cheeks and lips.  bactericidal properties to prevent excessive plaque formation.  Not interfere with healing.  dimensional stability to prevent salivary leakage.  not induce possible systemic detrimental effects and allergic reactions.  acceptable taste.  economical and easily available.  good shelf life.  Protection of the wound area:  Enhancement of patient comfort:.  Maintenance of a debris free area:  Control of bleeding: from trauma.  Periodontal dressings also protect newly exposed root surfaces from temperature changes and protect sutures.  Protects surgical healing areas from irritants such as hot or spicy foods. IV.

2025, Nigerian Journal of Medicine

The COVID-19 pandemic has proven a significant challenge to health care worldwide. Currently, many people have been infected and died from disease complications, as the it has neither curative nor preventive treatment yet. Health-care facilities in several countries have been overwhelmed. There has also been a tendency to focus on treating only COVID-19 patients. While measures such as social distancing and isolation may work for the populace, the medical personnel including orthopedic surgeons treat patients and carry out procedures that generate aerosols such as using bone drills and saws, thus putting them at higher risk. To this effect, worldwide, all surgeries that can be safely postponed are being postponed. The patient load in clinics is being reduced in conformity with the social distancing, and some countries have applied telemedicine to interact with outpatients. Due to the possibility of spread through aerosols or contact from contaminated surfaces and the relatively high viral load that health-care workers are exposed to, there is a need for specific personal protective equipment (PPE) for health-care workers. The current recommendation is to use N95 respirators, full-face coverage, and full-body PPE for all operations on COVID-19-positive patients. For suspected COVID-19-positive patients, the recommendation at the least is to use an N95 respirator or equivalent as well as a face shield. A meta-analysis of several randomized controlled trials has not

2025, South African Dental Journal

2025, South African Journal of Radiology

This article describes the CT and MRI findings as well as the histopathology of a rare case of a SNTCS, with the epicentre in the left nasal cavity involving the left maxillary sinus, with intracranial extension. To the authors' knowledge, this is the first case described in South Africa. A 44-year-old man presented with a 3-month history of a rapidly growing left-sided nasal mass. He complained of recurrent epistaxis, blocked nose and generalised headaches, concentrated mostly on the left side of his face; however, there were no visual or olfactory disturbances. His medical history included hypertension and previous pulmonary tuberculosis. Nasal endoscopic examination revealed a distended left nostril with a protruding, friable, haemorrhagic, exophytic, foul-smelling mass. The rest of the clinical examination was unremarkable. Sinonasal teratocarcinosarcoma (SNTCS) is a highly malignant and rare tumour characterised by a complex admixture of teratomatous and carcinosarcomatous components. In the head and neck area, it almost exclusively occurs in the sinonasal cavities; however, rare instances of nasopharyngeal and oral cavity involvement have been reported, with fewer than 100 cases reported in the literature. The contributed case involves the correlative CT, MRI and histopathology of a sinonasal teratocarcinosarcoma with intracranial involvement.

2025, South African Dental Journal

The glandular odontogenic cyst (GOC) remains a rare entity. It was initially named "sialo-odontogenic cyst" by Padayachee and Van Wyk in 1987 when they reported the first two cases. Thereafter the term glandular odontogenic cyst was suggested by Gardner et al. in 1988 and was subsequently adopted by the WHO. 1 Ciliated surface cells were also noted as were papillary projections of the epithelium into the cyst lumen. Mucicarmine stain was positive for mucin in goblet cells and in intra-epithelial microcystic (glandular or pseudoglandular) spaces. The morphological features were compatible with a glandular odontogenic cyst (Figure ).

2025, Baylor University Medical Center Proceedings

An epidermal inclusion cyst is a widespread benign intradermal lesion and may occur anywhere in the body. Normally, it appears as a non-tender, soft mass of variable size. Dissection usually reveals grayish-white or whitish gelatinous materials and a smooth inner surface. The overlying skin almost always shows unremarkable changes. On occasion, the cyst may rupture and induce an inflammatory reaction. It rarely turns malignant or displays a firmer mass. This study reports on a rare case of squamous cell carcinoma arising from the lining cells of an epidermal inclusion cyst, which was located in the left axillary region of a 68-year-old male patient. Clinically, it is difficult to differentiate between a benign and malignant cystic lesion. Histological examination normally yields the diagnosis. Once a diagnosis is confirmed, the tumor should be widely excised with a free margin. The outcome is always excellent. We therefore emphasize that all resected skin cystic specimens should undergo further microscopic examination to avoid any unnecessary misdiagnosis.

2025, Journal of Oral and Maxillofacial Surgery

2025, Annals of plastic surgery

This study reviewed the mini invasive technique, microautologous fat transplantation (MAFT), as a strategy in simultaneously treating sunken upper eyelids with multiple folds and recreating a double eyelid crease in Asian people. The MAFT was performed with the assistance of a patented medical device, the MAFT-GUN, on 34 patients who had sunken upper eyelids and multiple folds. Each delivered fat parcel was accurately and consistently maintained at 1/240 mL during placement. Follow-up was regularly performed with photography for comparison. Fifty-eight sunken upper eyelids with multiple folds were reconstructed. In addition to the ameliorative recontouring of hollowness, a natural eyelid crease was created postoperatively. Temporary swelling and bruising were noted several days after surgery without morbidities, such as fibrosis or nodulation. All of the patients were satisfied with the 1-time MAFT procedure. Fat grafting for sunken upper eyelids with multiple folds has been reporte...

2025, American Journal of Orthodontics and Dentofacial Orthopedics

Computerized cephalometric analysis can include both landmark identification and determination of linear or angular measurements. Although its use is time saving compared with a manual method, the accuracy of automatic landmark identification remains unclear. The purpose of this study was to evaluate the accuracy of a computerized automatic landmark identification system that used an edge-based technique. The technique divides the scanned cephalogram into 8 rectangular subimage regions. After the resolution of these subimages is reduced, the edges are detected and the landmarks are located automatically. Thirteen landmarks were selected for assessment on a set of 10 test cephalograms. The results showed that the errors between manual and computerized identification for landmarks were not significantly different (P > .05) for 5 of 13 landmarks: sella, nasion, porion, orbitale, and gnathion. These results suggest that the accuracy of computerized automatic identification is acceptable for certain landmarks only. Further studies to improve the accuracy of computerized automated landmark identification are needed. (

2025, International Journal of Oral-Medical Sciences

AIM OF STUDY: Salivary gland tumors are uncommon, and the epidemiological data of these tumors in various parts of the world can be helpful for a better understanding of their biology and clinical characteristics. Thus, this study was an epidemiological survey of salivary gland tumors in the western Uttar Pradesh population. MATERIALS AND METHODS: This retrospective study was a clinical review of our experience with different subtypes of salivary gland tumors, diagnosed from May 2004 to May 2010. The histological diagnoses were evaluated according to the 2005 WHO classification. These data were analyzed for the distribution of benign and malignant salivary tumors in minor salivary glands, male to female ratio, age range, and site of occurrence. RESULTS: A total of 1805 specimens were received; of these, 4% were diagnosed as salivary gland tumors, with a male to female ratio of 1:1.4. The mean age of the patients was 51.4 ± 18.1 years. Of the tumors, 59.5% were benign and 40.5% were malignant neoplasms, with the most common tumors being pleomorphic adenoma and mucoepidermoid carcinoma. The present study provides demographic data on a series of salivary gland tumors in the western Uttar Pradesh population. This study confirmed that some tumors have a predilection for certain sites, and that the risk of malignant disease is also greater at specific sites within the oral cavity.

2025, Journal of Oral and Maxillofacial Pathology

geographic clusters. Difference in nose types is signifi cant in categorization between races. 5 Nasal index is the most common nasal parameter which may relate to regional and climatic differences. Longer narrower noses are favored in cold and dry climates while broader noses seen in warmer and moisten climate may consequence of natural selection in human evolution. The morphological classifi cation of face and nose has been successfully adopted by international security agencies. However, the use of morphological facial features in personal identifi cation still remained inconclusive. 7 Facial identifi cation with nasal morphometry is becoming more signifi cant with the increase in crime rates, terrorist attacks. 8 Nasal index is also useful in anthropology in distinguishing racial and ethnic differences. Nasal index is the ratio of nasal width to the nasal height multiplied by 100. It exhibits sexual differences 11 and has become a useful tool in forensic sciences. Dimensions obtained have a great potential to guide clinical decision, public health policy, relevant in

2025, Dentistry Journal

This pilot split-mouth study aimed to evaluate and compare early postoperative discomfort and wound healing outcomes in post-extraction sockets after dental extraction performed with a Magnetic Mallet (MM), piezosurgery, and conventional instruments (EudraCT 2022-003135-25). Twenty-two patients requiring the extraction of three non-adjacent teeth were included. Each tooth was randomly assigned to a specific treatment (control, MM, or piezosurgery). Outcome measures were the severity of symptoms after surgery, wound healing assessed at the 10-days follow-up visit, and the time taken to complete each procedure (excluding suturing). Two-way ANOVA and Tukey’s multiple comparisons tests were performed to evaluate eventual differences between groups. There were no statistically significant differences between the compared methods in postoperative pain and healing, and no additional complications were reported. MM required significantly less time to perform a tooth extraction, followed by ...

2025, Journal of Stomatology, Oral and Maxillofacial Surgery

2025, Journal of Oral and Maxillofacial Surgery

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2025, Journal of Oral and Maxillofacial Surgery

2025, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

The main limitation of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) is difficulty in defining resection margins. The aim of this study was to compare the efficacy of the surgeon's experience and autofluorescence-guided bone surgery to delimit resection margins for necrotic bone. MRONJ requiring surgical treatment was classified according to American Association of Oral and Maxillofacial Surgeons staging. To detect vital bone and resection margins, patients of each stage were randomly assigned to 1 of 2 surgical groups: an autofluorescence-guided surgery (AF) group and a conventional surgery (non-AF) group based on the surgeon's experience. Bone samples from the 2 groups were analyzed histopathologically. The main outcomes were defined as the absence of bone exposure or infection at the time of evaluation. Infection was defined as the presence of swelling, pain, or numbness in the area. Measurements were collected preoperatively and 1 week, 1 mont...

2025

We present a Madelung disease case which affected in its progressive evolution the cervical anterior, submadibular, occipital and bilateral parotid areas. The excision of the lipoma located in the parotid area involved the dissection of the temporal zygomatic branches of the facial nerve which resulted in their different degree post-surgical paresis. We monitored the evolution of the paresis after the intake of nimodipine for 7 days immediately after the surgery, noticing total remission of the paresis 6 months later.

2025, Journal of Maxillofacial and Oral Surgery

Background Oral submucous fibrosis (OSMF) is a chronic disease of the oral cavity which presents clinically with burning sensation, leathery consistency of oral mucosa with palpable fibrous bands leading to reduced mouth opening. Though the evaluation of quality of life (QOL) in health care is gaining importance, researches regarding the evaluation of QOL in OSMF individuals are very sparse. Aim The aim of the present study is to evaluate the QOL assessment in OSMF patients through WHOQOL-BREF questionnaire. Methodology The study includes a total of 300 participants recruited from the outpatient department. The quality of life was assessed using the WHOQOL-BREF questionnaire. The raw scores for the physical health, psychological health, social relationships and environmental health domains were done on 4-20 scale suggested by the WHOQOL procedural manual. The analysis of variance (ANOVA) was used for the simultaneous comparison of mean scores for the four domains, and independent t test was used for the comparison of two means of domain scores. The participants with OSMF have a significant negative impact on the quality of life when compared with the participants without OSMF (P = 0.002). The environmental factors in the WHOQOL-BREF have shown a significant difference in the QOL of participants with OSMF than without OSMF (P = 0.001). Conclusion The oral submucous fibrosis has a negative impact on the quality of life in participants with OSMF specifically in social and environmental domains of the WHOQOL-BREF questionnaire.

2025

This study explores the ecological characteristics and medical applications of leeches, with a focus on their role in improving blood circulation and promoting healing. Initial field observations conducted in Ligligkot, Gorkha, Nepal documented various leech species in freshwater and moist environments, emphasizing their ecological diversity. The research then transitions into a comprehensive literature review, highlighting the biochemical properties of leech saliva—such as hirudin, calin, and hyaluronidase—and their anticoagulant, anti-inflammatory, and analgesic effects. Leech therapy, or hirudotherapy, has found renewed relevance in modern medicine, particularly in reconstructive surgery, osteoarthritis treatment, wound care, and cardiovascular disorders. The study synthesizes traditional Ayurvedic practices with contemporary clinical evidence, demonstrating that controlled and sterile use of medicinal leeches is effective and scientifically supported. Despite some risks, leech therapy offers a promising, natural adjunct to modern medical practices.

2025, Journal of Clinical Medicine

Background: Odontogenic sinusitis (ODS) is frequently encountered in ENT practice; however, there are no guidelines regarding its management. This study aims to analyse the results of endoscopic sinus surgery versus dental treatment in ODS. Additionally, we aim to demonstrate the benefit of associating endoscopic sinus surgery (ESS) to surgical closure of chronic oroantral fistulas (OAF) by comparing mean time to healing in patients who opted or not for concurrent ESS. Methods: Records of patients with ODS were reviewed. Group one consisted of patients with ODS caused by periapical pathology undergoing either endoscopic sinus surgery (ESS) or dental treatment. Resolution of ODS was considered treatment success and was compared between the two treatment strategies. Group two included patients with ODS and associated chronic oroantral communication. Time to healing was compared between patients undergoing OAF closure alone versus patients receiving associated ESS, using the Log-Rank t...

2025, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology

Drooling of saliva appears to be the consequence of a dysfunction in the coordination of the swallowing mechanism, resulting in excess pooling of saliva in the anterior portion of the oral cavity and the unintentional loss of saliva from the mouth. Drooling can produce significant negative effects on physical health and quality of life, especially in patients with chronic neurological disabilities. Various approaches to manage this condition have been described in the literature, including oral motor therapy, behavior modification via biofeedback, orofacial regulation therapy, drug therapy, radiotherapy, and surgical treatments. Minimally invasive modalities, such as injection of botulinum toxin, photocoagulation, and acupuncture, have also been reported. This article provides a comprehensive and thorough overview of drooling, with an emphasis on understanding its etiologies and modalities of treatment.

2025, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology

The loss of mandibular molars can result in a maxillary dentoalveolar extrusion, leading to an insufficient interarch space. In severe cases, this space must be regained before the prosthetic reconstruction of the opposite edentulous area. The posterior maxillary segmental osteotomy (PMSO) is a simple but precision technique to manage this problem; without which one can achieve a good surgical outcome but a poor final occlusion. The purpose of this paper was to present a case of PMSO for mandibular implant placement and to discuss the important steps. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:e1-e3)

2025, Journal of Oral and Maxillofacial Surgery

2025, Journal of Cranio-Maxillofacial Surgery

Results: The consensus derived from 14 experts and 41 participant surgeons, using 12 case scenarios and 27 statements. The experts and participants had similar decision on the treatment of condylar base, neck and head fractures, as well as similar opinion on complications of condylar fracture osteosynthesis. They had a parallel agreement on using open reduction with internal fixation (ORIF) as treatment of choice for condylar base and neck fractures in adults. Endoscopic approaches should be considered for selected cases, such as condylar base fractures with lateral displacement. There was also a growing tendency to perform ORIF in condylar head fractures. The experts also agreed to treat children (>12 years old) in the same way as adults and to consider open reduction in severely displaced and dislocated fractures even in younger children. Nevertheless, non-surgical treatment should be the first choice for children <6 years of age. The decision to perform surgery in children was based on factors influencing facial growth, appropriate age for ORIF, and disagreement to use resorbable materials in children. The experts and participating surgeons had comparable opinion on management of condylar fractures and complications of ORIF. Compared to the first Condylar Fracture Symposium 2007 in Strasbourg, ORIF may now be considered as the gold standard for both condylar base and neck fractures with displacement and dislocation. Although ORIF in condylar head fractures in adults and condylar fractures in children with mixed dentition is highly recommended, but this recommendation requires further investigations.

2025, Journal of Craniofacial Surgery

e read with great interest the article entitled, ''Follicular Cyst of the Jaw Developing Into a Keratocyst in a Patient With Unrecognized Gorlin-Goltz Syndrome,'' by Longobardi et al 1 in this journal. Although many features of this article highlight the useful information, some clinicopathologic aspects warrant discussion and can be listed as follows: (1) The term follicular cyst is less preferable than dentigerous cyst. The former term implies a derivation from the dental follicle, which is a mesodermal structure, not from odontogenic epithelium, whereas the literal meaning of dentigerous is tooth bearing, and hence, it is most appropriate for the lesion. Moreover, the term follicular cyst may be confused with follicular cysts of the ovary and hair follicular cysts. 2 (2) The first diagnosis of an odontogenic keratocyst (OKC) as a dentigerous cyst may be due to the interobserver variability between pathologists, such as between a general pathologist versus an oral pathologist, or even among oral pathologists. Furthermore, inflammation can overshadow the lesion and leads to incorrect diagnosis. It is our experience that 6 (5%) of 120 OKCs with secondary infection were diagnosed as a radicular cyst by clinical, radiographic, and histological means. The definite diagnosis of these 6 cysts was established after their recurrences. (3) In our 10-year series of 695 odontogenic cysts, there were 120 nonsyndromic OKCs and 10 OKCs associated with Gorlin-Goltz syndrome (GGS). Of those, 2 GGS cases developed other manifestations of the syndrome several years after the enucleation of OKCs. 5,7 (4) When a recurrent OKC presents with parakeratinization, intramural epithelial remnants, and microcysts, GGS should be suspected, and excision of overlying soft tissue (if infiltrated) is recommended. 8 Our algorithm for managing nonsyndromic OKCs and cyst-like lesions (expansile radiolucent lesions with no calcified matrix) of the jaws and other details was presented in our previous publications.

2025, Australasian Medical Journal

Tolosa-Hunt syndrome (THS) related neurological symptoms are described in literature as "unilateral", "recurrent", "episodic", "intense", "severe", "lancinating" or "stabbing" pain on the upper face and forehead and may be misdiagnosed due to the similarity of few symptoms and a significant number of common characteristics between both conditions. The aim of this brief report is to indicate some important clinical insights related to Tolosa Hunt syndrome, and to give a frank account on the multidisciplinary approach on neurological-related symptomatology in maxillofacial region. We analysed a selection of patients with such clinical picture. To better describe the proper management of clinical cases, we report a 50-year-old female reporting an history of two years of recurrent, severe stabbing pain around the right eye, prominence of her cheek and forehead. Her general dentist first mistakenly diagnosed toothache and, thus, it was subsequently misdiagnosed the trigeminal neuropathy (TN). Reported exemplificative case presented a mild ptosis, diplopia of the right eye, corneal reflex loss, paresthesia and hyperesthesia of upper part of left side of face. Magnetic resonance imaging (MRI) findings were suggestive of THS. Complete resolution of symptoms was achieved with oral Prednisolone and constant monitoring of symptoms. THS may be added to the long list of differential diagnosis of TN and general dentist and oral surgeons should be informed about such rare causes of facial pain through continued medical education programs.

2025, Journal of Oral and Maxillofacial Surgery

2025, Head & Neck Oncology

The expression non Hodgkin lymphoma is used to cover a wide group of lymphoid neoplasias unrelated to Hodgkin's disease, due to the huge histological variety and the tendency to affect organs and tissues that does not physiologically contain lymphoid cells. The intraoral location is not frequent (3 -5 percent of cases) and the initial manifestations of the disease rarely take place here. Case presentation: We describe the case of a 73 years old Italian caucasian male who came to our attention with a tongue lesion. The clinical manifestation was macroglossia and bleeding, probably deriving from the tongue-bite injuries. The patient had been complaining of dyspnea for 48 hours. Conclusion: A tongue affected by non-Hodgkin's lymphoma rarely occurs. In spite of this, this possibility should always be considered for the differential diagnosis of benign and malignant lesions affecting such area. A rapid diagnostic assessment, together with an adequate histopathologic verification, are indeed essential to improve the management and the prognosis of this disease.

2025, Journal of Oral and Maxillofacial Surgery

Purpose:. The aim was to evaluate the outcome of a short wide body implant in the atrophic posterior jaw without grafting procedure. Materials and methods:Patients treated with a tapered wide body implant of 8-9 mm width and 7-9 mm length (Max® implant, Southern Implants®, Irene, South Africa) were recalled to scrutinize implant survival. Preoperative cone beam CT images were analysed to measure bone height in reference to the mandibular canal and sinus floor. Results: 57 implants were inserted in 18 males and 24 females following a 2-stage procedure and delayed loading. The mean follow-up was 15 months (SD 10,range 1-32), with 63.2% of the implants having at least 1 year and 26.3% having at least 2 years follow-up. 46 implants were inserted in the posterior maxilla and 11 in the mandible. 15 were placed in an extraction socket and 42 in healed bone. 13 implants were supporting a single crown. 2 implants failed, resulting in a survival rate of 96.5%, respectively 90.9% and 97.8% for mandible and maxilla. This was not affected by gender, jaw, immediate or delayed placement, implant diameter and length or the use of a bone substitutes. The mean preoperative bone height was 7.21mm in maxilla and 8.76mm in mandible. In 41 cases, implant length surpassed available bone height. Conclusions: Despite the compromised bone condition and height, the survival of 96.5% is comparable to normal implants and an alternative for grafting procedures. This is probably related to the enlarged implant surface area and the good primary stability.

2025, Modern Research in Dentistry

The paper presents an innovation of a mandibular distractor device. It is designed to facilitate applied experimental research in the field of distraction osteogenesis process. The device is configured for attachment to opposing sides of... more

2025

Oral submucous fibrosis is a chronic debilitating disease associated with restricted mouth opening and poor oral hygiene. The treatment aims at good release of fibrosis and to provide long term results in terms of mouth opening. With the increasingly widespread application of reliable microvascular free tissue transfer techniques for oral cavity reconstruction, the routine need for a variety of local and regional flaps has decreased. Various local grafts have been used to cover the buccal mucosal defects after the fibrotic bands are released in oral submucous fibrosis. Successful use of inferiorly based nasolabial flaps in the management of oral submucous fibrosis is projected. In this article, the focus is on the utility of the pedicled nasolabial flap to achieve this goal. Care was taken for post-operative physiotherapy, and was followed up regularly for one year. Flap healed without evidence of infection, dehiscence, or necrosis. The inferiorly based nasolabial "islanded" flaps provide reliable coverage of defects of the buccal mucosa and improves mouth opening.

2025, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Dentigerous cyst is the most common developmental odontogenic cyst of the jaws and is frequently noted as an incidental finding on radiographs. The reported occurrence of bilateral dentigerous cysts in the absence of a developmental syndrome is rare and those involving canines are even rarer. The current manuscript highlights two cases of bilateral dentigerous cysts involving maxillary and mandibular canines in non-syndromic patients along with an exhaustive review of literature.

2025, International Journal of Oral and Maxillofacial Surgery

Bax mRNA therapy has a stronger antitumor effect than Bax gene therapy using a plasmid. Systemic administration was effective compared to the local injection that we examined in the past. These results suggest that Bax mRNA lipofection... more

2025, Journal of Oral and Maxillofacial Research

The aim of this case report is to present an interesting case of bisphosphonate-related osteonecrosis of the jaw, involving the maxilla and the maxillary sinus, as a result of per os administration of ibandronic acid. Methods: A female... more

2025, European Annals of Dental Sciences

Purpose: Comparison of the knowledge levels of patients in different demographic groups with and without impacted third molar experience. The authors' expectation was that experienced patients would have a higher level of knowledge. Materials & Methods: Sixty-five patients (34 experienced, 31 inexperienced) with impacted third molar extraction indication were included in the study. A questionnaire with 23 questions concerning different operative phases and where the patients could write down their own questions were administered before surgeries. Demographic data (gender, age group and educational status) were also noted. Results: Questionnaire success did not show a significant difference in different demographic groups and between patients with and without experience of third molar tooth extraction (p>0.05). Conclusion: Dental surgeons should do their best to provide written and verbal information before surgical procedures, each patient should be evaluated as a first-time patient, regardless of demographic data and past experiences. It should not be neglected to provide a detailed information process.

2025, Journal of Oral Diagnosis

Introduction: Central giant cell lesion (CGCL) is an osteolytic lesion mainly found in gnathic bones of children and young adults. It is a benign lesion with variable clinical and radiographic behavior but it may be aggressive. Intralesional corticoid application has been proposed as an alternative and complementary procedure to radical surgical treatment, to minimize functional and aesthetic damage. Objectives: This paper aims to report a case of a pediatric patient with CGCL of the jaw, which was treated withconservative treatment of two intralesional applications of triamcinolone and discuss if there is an ideal waiting period between nonoperative treatment and the need for surgical intervention. Methods: This report shows a quantitative analysis of histological alterations induced by intralesional infiltrations of triamcinolone into a clinical resistant CGCL. A 7-year-old patient was submitted to a conservative treatment of two intralesional applications of triamcinolone into a mandible CGCL. Results and Conclusion: Histological evaluation showed reduction in the number of blood vessels and of giant multinucleated cells, beside an increased collagen production. The triamcinolone induced histological alterations seem to interfere in the clinical behavior of the lesion thus, recommending a less radical surgical treatment.

2025, Journal of Oral and Maxillofacial Pathology

The purpose of this paper is to report a case of chondroblastic osteosarcoma in the region of the maxilla, with 5 months of evolution. The term osteosarcoma refers to a heterogeneous group of malignancies with bone formation or mesenchymal tissue with histopathological evidence of osteogenic differentiation. The pattern of chondroblastic osteosarcoma represents 25% of all reported cases of this neoplasm. Its histopathological diagnosis is based on the predominance of a chondroid matrix formed in the midst of neoplastic cells. A woman patient, 27-year old, melanoderm, presented on extraoral exam with facial asymmetry caused by the a swelling in the premaxillary region with upper lip protrusion. Intraoral exam showed a maxillary tumefaction with involvement of the vestibular and palatine regions. The computerized tomography (CT) analysis exhibited a radiolucent mass with dispersed areas of radiopacity, with poorly defi ned and indistinct peripheral edges. The patient was subjected to incisional biopsy and histopathological examination showed the presence of a malignant neoplasm of mesenchymal origin characterized by the presence of irregular bone trabeculae dispersed among mildly atypical chondroblastic cells. The World Health Organization (WHO) recognizes several variants that differ in location, clinical behavior and degree of cellular atypia. The conventional or classical osteosarcoma is the most frequent variant, which develops within the medullary bone. This report illustrates the rapid evolution of one of the histological variants of osteosarcoma.

2025, European journal of medical research

The aim of this study was to evaluate the effect of local betamethasone injection into the pterygomandibular space on postoperative neurosensory deficits. A prospective controlled clinical study was conducted on 16 patients (6 male, 10 female; mean age, 24.95 ± 9.22 years) who underwent bilateral sagittal ramus osteotomy for mandibular discrepancies. One side of each patient's mandible was randomly selected as the control side, and the opposite side as the experimental side. On the experimental side, a solution of betamethasone (6 mg/1 ml) was injected into the pterygomandibular space after the completion of wound closure. Neurosensory tests, including light touch, two-point discrimination, direction of movement, thermal sensitivity, and pin-prick discrimination, were performed. The follow-up period ranged between 6 and 12 months, according to the particular sensory test. The Fisher exact test was used to analyse the data. The light touch sensation was abnormal in 75% of the control side and 31% of the study side, with the difference being significant (p = 0.03). However, at 6 months, all the study cases regained touch sensation, compared to 69% of the control side. No significant difference in direction movement discrimination was seen; however, at 3 months, the study side showed significantly less direction sensation (19%) compared to the control side (56%) (p = 0.02). There was no significant difference in the two-point discrimination; however, at 3 months, the study side had a significantly less abnormal two-point sensation (13%) than the control side (56%) (p = 0.02). In addition, no significant difference was noted in thermal sensitivity or pin-prick sensation. Betamethasone injection into the pterygomandibular space reduces neurosensory disturbances after bilateral sagittal split ramus osteotomies nd leads to faster recovery of sensations.

2025, Head & Face Medicine

The purpose of this study was to evaluate the effect of adding a fourth osteotomy at the lower border of the mandible on the lingual cortical fracture pattern in bilateral sagittal split ramus osteotomies. The sample of the study consisted of 20 patients (12 male and 8 female, with a mean age of 26.79 ± 7.12 years) with mandibular deformities who needed bilateral sagittal split ramus osteotomy. One side underwent a traditional sagittal split ramus osteotomy, and the procedure was modified on the other side by adding a 1 cm horizontal osteotomy at the lower border of the mandible, just distal to the caudal end of the vertical buccal osteotomy cut. A 3D CBCT was used to identify the split pattern. In the total sample, 40% of the lingual splits ran vertically toward the lower border of the mandible (LSS1), 20% of the splits passed horizontally to the posterior border of the mandible (LSS2), 32.5% of the splits took place along the inferior alveolar canal (LSS3), and 7.5% of the splits were unfavourable fractures (LSS4). On the inferior border osteotomy sides, the distribution of LSS1, LSS2, LSS3, and LSS4 was 10 (25%), 6 (15%), 4 (10%), and 0 (00), respectively. Their distribution on the sides without inferior border osteotomy was 6 (15%), 8 (20%), 13 (32.5%), and 3 (7.5%), respectively. Statistical analysis revealed a significant difference between the two groups (p < 0.05). Inferior border osteotomy tends to direct the lingual split fracture line toward the lower and posterior borders of the mandible and minimizes bad splits; however, further studies are needed to confirm our findings.

2025, Advanced Medical Journal

Background and objectives: The proximity of inferior alveolar canal to roots of lower third molar is one of the serious challenges facing surgeons during extraction of that tooth. There are different types of this relation, mainly: away, in direct contact and crossing the canal. The aim is to evaluate the relation between roots of lower third molar and inferior alveolar canal, in Winter classification of impaction of impaction to decide whether to do surgery or to ask for Cone Beam Computed Tomography first. Methods:Orthopantomographs f 206 cases were retrospectively evaluated: the presence of impaction; applying Winter classification; studying roots, numbers; and their relation to the canal (away from, in direct contact and crossing). Results: One hundred and twenty-four cases were with lower third molar impaction; mean age (29.5 ± 6.2); mesioangular was the most common type of impaction. In general, 24 (19.5%) cases were away; 51 (40.5%) cases were with a direct contact; 49 (39.5%...

2025, Dental update

Lingual displacement of lower third molar teeth is a well-recognized complication of extraction. The purpose of this article is to report the case of a displaced lower third molar tooth into the pa...

2025, Open Journal of Obstetrics and Gynecology

Pemphigoid Gestational (PG), an uncommon autoimmune bullous dermatosis of pregnancy, stands out between the specific dermatological diseases of the gestational period. Despite being self-limited and benign, it has a significant impact on women's health, both physiologically and psychologically. In addition, it promotes pathological changes that can be complicated during pregnancy. This paper reports the case of a pregnant patient with blistering lesions throughout the whole body. The diagnostic hypothesis initially involved PG and the specific treatment with corticosteroids was initiated, but after the anatomopathological result of the biopsy there has been diagnostic confusion with drug hypersensitivity, since clinical and histological manifestations were exuberant for both pathologies. As the lesions recurred in the puerperium, due to the corticoid abstention that was administered for the treatment of the differential diagnosis, a diagnostic review with immunofluorescence was made and confirmed PG. It is important to establish a correct diagnosis therefore, in order to improve the quality of care offered to the mother-baby binomial.

2025, Indian Journal of Sleep Medicine

The aim of this case report is to highlight the use of maxillomandibular surgical advancement procedures to treat the symptoms of obstructive sleep apnea (OSA) in addition to improving esthetics, function, and stability in patients with skeletal jaw discrepancies. Background: Obstructive sleep apnea is a condition which is frequently encountered by the orthodontist both in children and adults due to the strong correlation with various craniofacial risk factors. Although "continuous positive airway pressure (CPAP) therapy" is the gold standard for management of symptoms of OSA, patients with underlying skeletal discrepancies of the jaws can benefit from maxillomandibular surgical advancement procedures which can provide long-term benefits. Case description: This case describes the interdisciplinary management of a 28-year-old man suffering from moderate OSA. The cause of OSA was determined to be multifactorial including lifestyle choices in addition to craniofacial risk factors of a skeletal class II jaw bases, retrognathic mandible, horizontal growth pattern, and increased submental fat deposition. The case was managed by orthosurgical line of treatment with mandibular advancement surgery to correct the underlying skeletal deformity. Post-orthognathic surgery, occlusion was settled and case was finished with class I skeletal and dental relationship with optimal functional occlusion and good esthetics. Posttreatment evaluation also revealed a marked improvement in sleep parameters with a downgrade from moderate-to-mild OSA. The result highlights how suitable and timely intervention in cases of OSA can have favorable outcomes and the value of maxillomandibular advancement techniques in amelioration of OSA. Clinical significance: Maxillomandibular surgical advancement procedures can be of great benefit to patients who suffer from symptoms of OSA owing to the underlying skeletal jaw discrepancies.

2025, Journal of maxillofacial and oral surgery

Objective of this study is to evaluate the new bone formation in bony defects following insertion of hydroxyapatite graft and to compare the efficacy and regenerative potential of this bone graft material. The patients having osseous defects after surgery were selected. Preoperatively a brief history, examination, relevant blood investigation and radiographs were taken. Post operative observation period of 6 months was planned. Radiographic and bone scintigraphic (isotope study of bone activity) evaluation of bone specimens was completed in defined time. Radiographic evaluation indicated increased calcification surrounding the material, indicative of acceptance of the graft to the bone. Bone scintigraphic evaluation indicated area of increased bone metabolism and is evidenced as area of increased radiotracer uptake, namely 'hot…

2025, Journal of Oral and Maxillofacial Surgery

Purpose: To investigate the efficacy of temporomandibular joint (TMJ) lavage (arthrocentesis or arthroscopy) for the treatment of temporomandibular disorders in reducing pain and improving jaw motion. Patients and Methods: We performed a systematic review of the literature and meta-analysis of randomized controlled trials (RCTs) comparing TMJ lavage with conservative measures. The data sources were MEDLINE, Embase, CENTRAL (Cochrane Central Register of Controlled Trials), Scopus, Web of Science, and reference lists of relevant articles. Two independent reviewers identified RCTs by using controlled vocabulary (MeSH, Emtree) and free text terms. Data extracted from the selected studies included population characteristics, interventions, outcomes, and funding sources. Risk of bias was assessed with the Cochrane Collaboration risk assessment tool for RCTs. Results: Five studies met the inclusion criteria, for a total of 308 patients. Of these studies, 3 were categorized as having a high risk of bias and 2 had a low risk. The summary effect of the 5 studies showed a reduction in pain in the intervention group at 6 months (-0.63; 95% confidence interval [CI], -0.90 to -0.37; P < .00001; I 2 = 88%) and 3 months (-0.47; 95% CI, -0.75 to -0.19; P = .001; I 2 = 85%). This was not the case at 1 month. No difference in mouth opening was observed at 6 months (-0.21; 95% CI, -1.82 to 1.40; P < .80; I 2 = 74%), 3 months (0.20; 95% CI, -1.81 to 2.20; P = .85; I 2 = 68%), and 1 month (-1.18; 95% CI, -2.90 to 0.55; P = .18; I 2 = 0%). Conclusions: Given the relatively small number of patients included in this meta-analysis, the high risk of bias in 3 studies, and the statistical and clinical heterogeneity of the included studies, the use of TMJ lavage for the treatment of temporomandibular disorders should be recommended with caution because of the lack of strong evidence to support its use.

2025

The use of Platelet-Rich-Plasma (PRP) may provide a new and improved treatment option for early and late Temporomandibular Joint (TMJ) disc displacement. However, there are no long-term studies on its use in TMJ arthritis in the literature. The present study evaluate 28 patients with different degrees of disc displacement over a period of time. These patients had experienced no pain reduction following conservative approaches (including splint therapy) and minimally invasive arthrocentesis treatment. All patients had evidence of disc displacement associated with pain and discomfort, and sometimes clicking. The patients were without systemic joint disease, septicarthritis, or autoimmune arthritis. Only patients who had not responded to conservative therapy were included in the present study. Pain intensity was recorded for each patient using a 0-10 VAS scale. Maximum Inter-incisal Opening (MIO) was also recorded. This assessment was performed at the pretreatment stage and then exam...