Hypoxia-inducible factor | biology | Britannica (original) (raw)
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adaptation to hypoxia
In hypoxia …of a molecule known as hypoxia-inducible factor (HIF). Under normal oxygen conditions, a protein called von Hippel-Lindau (VHL) undergoes chemical modification enabling it to bind to HIF, thereby marking HIF for degradation. However, when oxygen levels are low, VHL is not modified and therefore cannot attach to HIF; as a… Read More
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Kaelin
In William G. Kaelin, Jr. …to another protein, known as hypoxia-inducible factor (HIF), which stimulates cell proliferation when oxygen is scarce. At normal oxygen levels, VHL binding marks HIF protein for degradation. When oxygen availability is low, however, VHL no longer undergoes modification and therefore cannot bind to HIF, which allows HIF activation, and hence… Read More
Ratcliffe
In Peter J. Ratcliffe …hydroxylation on a molecule called hypoxia-inducible factor (HIF) dictates how cells respond to changes in oxygen levels. When the modification is present, HIF is marked for degradation. When absent, HIF persists, and key cellular processes are altered to facilitate adaptation to hypoxic conditions, thereby enabling cells to continue to grow… Read More
Semenza
In Gregg L. Semenza …and for his discovery of hypoxia-inducible factor (HIF), a molecule that is activated by reduced oxygen availability in cells and that plays a critical role in enabling cells to survive in certain disease states. Semenza’s research opened a door for the investigation and development of novel treatments for diseases such… Read More
