Cellosaurus cell line HMT-3522 S2 (CVCL_2500) (original) (raw)
Cell line name
HMT-3522 S2
Synonyms
HMT-3522-S2; HMT-3522S2; HMT3522S2; S2; S-2; HMT-3522/gt-1; gt-1; HMT-3522/growth-transformed-1
Accession
CVCL_2500
Resource Identification Initiative
To cite this cell line use: HMT-3522 S2 (RRID:CVCL_2500)
Comments
Population: Caucasian.
Characteristics: Established from parent cell line by permanent ommission of EGF in culture medium.
Donor information: Established from a nontumorigenic fibrocystic breast lesion (from parent cell line).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
- Mutation; HGNC; 11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Unspecified (PubMed=7982476).
Species of origin
Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy
Parent: CVCL_6855 (HMT-3522)
Children:
Sex of cell
Female
Age at sampling
50Y
Category
Spontaneously immortalized cell line
STR profile
Source(s): ECACC=98102211
Markers:
| Amelogenin | X |
|---|---|
| CSF1PO | 11,12 |
| D5S818 | 9,11 |
| D7S820 | 9 |
| D13S317 | 11 |
| D16S539 | 11,13 |
| TH01 | 9,9.3 |
| TPOX | 11 |
| vWA | 14,17 |
[ **Run an STR similarity search on this cell line**](/cellosaurus-str-search/?name=HMT-3522 S2&Amelogenin=X&CSF1PO=11,12&D13S317=11&D16S539=11,13&D5S818=9,11&D7S820=9&TH01=9,9.3&TPOX=11&vWA=14,17&)
Publications
PubMed=7982476; DOI=10.1006/excr.1994.1355
Moyret C., Madsen M.W., Cooke J., Briand P., Theillet C.
Gradual selection of a cellular clone presenting a mutation at codon 179 of the p53 gene during establishment of the immortalized human breast epithelial cell line HMT-3522.
Exp. Cell Res. 215:380-385(1994)
PubMed=8616848
Briand P., Nielsen K.V., Madsen M.W., Petersen O.W.
Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.
Cancer Res. 56:2039-2044(1996)
PubMed=18316601; DOI=10.1158/0008-5472.CAN-07-2225; PMCID=PMC2662716
Rizki A., Weaver V.M., Lee S.-Y., Rozenberg G.I., Chin K., Myers C.A., Bascom J.L., Mott J.D., Semeiks J.R., Grate L.R., Mian I.S., Borowsky A.D., Jensen R.A., Idowu M.O., Chen F.-Q., Chen D.J., Petersen O.W., Gray J.W., Bissell M.J.
A human breast cell model of preinvasive to invasive transition.
Cancer Res. 68:1378-1387(2008)
Cross-references
Cell line collections (Providers)
ECACC; 98102211
Cell line databases/resources
cancercelllines; CVCL_2500
Encyclopedic resources
Wikidata; Q54889969
Polymorphism and mutation databases
Entry history
Entry creation
04-Apr-2012
Last entry update
10-Sep-2024
Version number
19