| Synonyms |
MDA 231 BoM 1833; BoM-1833; 1833 BoM; MDA-MB-231 1833 BoM; MDA-MB-231-1833; MDA-MB-231 subline 1833; MDA-MB-231 Bone Tropic 1833 subclone; 1833 |
| Accession |
CVCL_DP48 |
| Resource Identification Initiative |
To cite this cell line use: MDA-BoM-1833 (RRID:CVCL_DP48) |
| Comments |
Group: Triple negative breast cancer (TNBC) cell line.Population: Caucasian.Characteristics: Established from bone metastasis of nude mice inculated with the parent cell line.Omics: Proteome analysis by 2D-DE.Omics: Secretome proteome analysis.Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
| Sequence variations |
Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line). |
| Disease |
Breast adenocarcinoma (NCIt: C5214) |
| Species of origin |
Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_0062 (MDA-MB-231) |
| Sex of cell |
Female |
| Age at sampling |
51Y |
| Category |
Cancer cell line |
| STR profile |
Source(s): MSKCCMarkers:AmelogeninX CSF1PO12,13 D2S133820,21 D3S135816 D5S81812 D7S8208 D8S117913 D13S31713 D16S53912 D18S5111,16 D19S43311 D21S1130,33.2 FGA22,23 TH017,9.3 TPOX8,9 vWA15 Run an STR similarity search on this cell line |
| Publications |
PubMed=12842083; DOI=10.1016/S1535-6108(03)00132-6 Kang Y.-B., Siegel P.M., Shu W.-P., Drobnjak M., Kakonen S.-M., Cordon-Cardo C., Guise T.A., Massague J. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3:537-549(2003) PubMed=18425382; DOI=10.3892/or.19.5.1237 Selicharova I., Sanda M., Mladkova J., Ohri S.S., Vashishta A., Fusek M., Jiracek J., Vetvicka V. 2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: comparison with parental cell line MDA-MB-231. Oncol. Rep. 19:1237-1244(2008) PubMed=26649326; DOI=10.1016/j.dib.2015.09.039; PMCID=PMC4644255 Cox T.R., Schoof E.M., Gartland A., Erler J.T., Linding R. Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism. Data Brief 5:621-625(2015) |
| Cross-references |
|
| Cell line databases/resources |
cancercelllines; CVCL_DP48 |
| Encyclopedic resources |
Wikidata; Q54904574 |
| Proteomic databases |
PRIDE; PXD000397 |
| Entry history |
|
| Entry creation |
13-Jul-2016 |
| Last entry update |
19-Dec-2024 |
| Version number |
19 |