| Synonyms |
Human Microglia Clone 3; CHME-3; CHME3 |
| Accession |
CVCL_II76 |
| Resource Identification Initiative |
To cite this cell line use: HMC3 (RRID:CVCL_II76) |
| Comments |
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; SV40 large T antigen.Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).Derived from site: In situ; Fetal brain; UBERON=UBERON_0006238.Cell type: Microglial cell; CL=CL_0000129. |
| Species of origin |
Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy |
Children: CVCL_D9WB (Ubigene HMC3 CLEC3B KO) |
| Sex of cell |
Sex unspecified |
| Age at sampling |
8-10FW |
| Category |
Transformed cell line |
| STR profile |
Source(s): ATCC=CRL-3304; CLS=300102Markers:AmelogeninX CSF1PO10,11 D2S133817,25 D3S135816,18 D5S81811,12 D6S104311 D7S8209,11 D8S117913,14 D12S39116,21 D13S31711 D16S53912,13 D18S5118 D19S43315,15.2 D21S1130,31.2 FGA21,25 Penta D10,14 Penta E7,13 TH016 TPOX8,9 vWA17,19 [ **Run an STR similarity search on this cell line**](/cellosaurus-str-search/?name=HMC3&Amelogenin=X&CSF1PO=10,11&D12S391=16,21&D13S317=11&D16S539=12,13&D18S51=18&D19S433=15,15.2&D21S11=30,31.2&D2S1338=17,25&D3S1358=16,18&D5S818=11,12&D6S1043=11&D7S820=9,11&D8S1179=13,14&FGA=21,25&Penta D=10,14&Penta E=7,13&TH01=6&TPOX=8,9&vWA=17,19&) |
| Publications |
PubMed=7478261; DOI=10.1016/0304-3940(94)11792-H Janabi N., Peudenier S., Heron B., Ng K.H., Tardieu M. Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen. Neurosci. Lett. 195:105-108(1995) PubMed=16371321; DOI=10.1007/BF03033980 Lindberg C., Hjorth E., Post C., Winblad B., Schultzberg M. Cytokine production by a human microglial cell line: effects of beta-amyloid and alpha-melanocyte-stimulating hormone. Neurotox. Res. 8:267-276(2005) PubMed=20375612; DOI=10.1159/000235563 Li B., Bedard K., Sorce S., Hinz B., Dubois-Dauphin M., Krause K.-H. NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression. J. Innate Immun. 1:570-581(2009) PubMed=30200996; DOI=10.1186/s12974-018-1288-0; PMCID=PMC6131758 Dello Russo C., Cappoli N., Coletta I., Mezzogori D., Paciello F., Pozzoli G., Navarra P., Battaglia A. The human microglial HMC3 cell line: where do we stand? A systematic literature review. J. Neuroinflammation 15:259.1-259.24(2018) |
| Cross-references |
|
| Cell line collections (Providers) |
ATCC; CRL-3304 CLS; 300102 Ubigene; YC-C131 |
| Encyclopedic resources |
Wikidata; Q54889911 |
| Entry history |
|
| Entry creation |
01-Dec-2016 |
| Last entry update |
10-Sep-2024 |
| Version number |
12 |