Cellosaurus cell line IIICF (CVCL_ZT89) (original) (raw)

Cell line name

IIICF

Synonyms

III-CF

Accession

CVCL_ZT89

Resource Identification Initiative

To cite this cell line use: IIICF (RRID:CVCL_ZT89)

Comments

Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.

Sequence variations

• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Heterozygous; Note=Impairs TP53 splicing dramatically (PubMed=1467311).

Disease

Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

Sex of cell

Female

Age at sampling

30-40Y

Category

Finite cell line

Publications

PubMed=1467311
Sally Gail Warneford, Leah J. Witton, Megan L. Townsend, Peter B. Rowe, Roger Robert Reddel, Luciano Dalla-Pozza, Geoff Symonds;
Germ-line splicing mutation of the p53 gene in a cancer-prone family.
Cell Growth Differ. 3:839-846(1992)

PubMed=7651392; DOI=10.1128/mcb.15.9.4745; PMCID=PMC230718
Eileen M. Rogan, Tracy M. Bryan, Bharati Hukku, Kenneth MacLean, Andy C.-M. Chang, Elsa L. Moy, Anna Englezou, Sally Gail Warneford, Luciano Dalla-Pozza, Roger Robert Reddel;
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.
Mol. Cell. Biol. 15:4745-4753(1995)

PubMed=19935656; DOI=10.1038/nbt.1587
Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel;
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity.
Nat. Biotechnol. 27:1181-1185(2009)

Cross-references

Encyclopedic resources

Wikidata; Q98126771

Entry history

Entry creation

02-Jul-2020

Last entry update

19-Dec-2024

Version number

8