Gene Ontology Classifications (original) (raw)

Gene Ontology Classifications

Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable Rho-dependent protein serine/threonine kinase activity; aspartic-type endopeptidase inhibitor activity; and small GTPase binding activity. Involved in several processes, including podocyte cell migration; positive regulation of focal adhesion assembly; and response to angiotensin. Acts upstream of or within several processes, including apical constriction; bleb assembly; and negative regulation of motor neuron apoptotic process. Located in several cellular components, including cytoplasmic stress granule; lamellipodium; and ruffle. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1).

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP

Inferred from experiment

HMP

Inferred from high throughput mutant phenotype

HGI

Inferred from high throughput genetic interaction

HDA

Inferred from high throughput direct assay

HEP

Inferred from high throughput expression pattern

IDA

Inferred from direct assay

IEP

Inferred from expression pattern

IGI

Inferred from genetic interaction

IMP

Inferred from mutant phenotype

IPI

Inferred from physical interaction

Homology:

IAS

Inferred from ancestral sequence

IBA

Inferred from biological aspect of ancestor

IBD

Inferred from biological aspect of descendant

IKR

Inferred from key residues

IMR

Inferred from missing residues

IRD

Inferred from rapid divergence

ISA

Inferred from sequence alignment

ISM

Inferred from sequence model

ISO

Inferred from sequence orthology

ISS

Inferred from sequence or structural similarity

Automated:

IEA

Inferred from electronic annotation

RCA

Reviewed computational analysis

Other:

IC

Inferred by curator

NAS

Non-traceable author statement

ND

No biological data available

TAS

Traceable author statement

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