| Name |
Amoxapine (JP18/USP/INN);Asendin (TN) |
| Product |
|
| Generic |
AMOXAPINE (Actavis Pharma), AMOXAPINE (Chartwell RX) |
| Formula |
C17H16ClN3O |
| Exact mass |
313.0982 |
| Mol weight |
313.78 |
| Structure |
 |
| Simcomp |
|
| Class |
Neuropsychiatric agent DG01730 Non-selective monoamine reuptake inhibitor DG01728 Tricyclic antidepressantMetabolizing enzyme substrate DG01644 CYP2D6 substrate |
| Remark |
Therapeutic category: 1179ATC code: N06AA17Product: D00228<JP/US> |
| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
| Disease |
Depression [DS:H01646] |
| Target |
SLC6A4 (HTT) [HSA:6532] [KO:K05037]SLC6A2 (NAT1) [HSA:6530] [KO:K05035] |
| Pathway |
hsa04721 Synaptic vesicle cyclehsa04726 Serotonergic synapse |
| Metabolism |
Enzyme: CYP2D6 [HSA:1565] |
| Interaction |
|
| Structure map |
map07027 Antidepressantsmap07028 Antipsychoticsmap07234 Neurotransmitter transporter inhibitors |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N06 PSYCHOANALEPTICS N06A ANTIDEPRESSANTS N06AA Non-selective monoamine reuptake inhibitors N06AA17 Amoxapine D00228 Amoxapine (JP18/USP/INN) <JP/US>USP drug classification [BR:br08302] Antidepressants Tricyclics Amoxapine D00228 Amoxapine (JP18/USP/INN)Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 117 Psychotropics 1179 Others D00228 Amoxapine (JP18/USP/INN)Drug groups [BR:br08330] Neuropsychiatric agent DG01730 Non-selective monoamine reuptake inhibitor D00228 Amoxapine DG01728 Tricyclic antidepressant D00228 Amoxapine Metabolizing enzyme substrate DG01644 CYP2D6 substrate D00228 AmoxapineDrug classes [BR:br08332] Neuropsychiatric agent DG01730 Non-selective monoamine reuptake inhibitor D00228 AmoxapineTarget-based classification of drugs [BR:br08310] Transporters Solute carrier family SLC6 SLC6A2 (NAT1) D00228 Amoxapine (JP18/USP/INN) <JP/US> SLC6A4 (HTT) D00228 Amoxapine (JP18/USP/INN) <JP/US>Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00228 AmoxapineDrug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00228 |
| Other DBs |
CAS: 14028-44-5PubChem: 7847295ChEBI: 2675LigandBox: D00228NIKKAJI: J3.129A |
| LinkDB |
|
| KCF data |
ATOM 22 1 C2y C 9.4323 -15.7409 2 C8y C 8.5912 -14.6326 3 C8y C 8.9260 -13.2774 4 O2x O 10.1856 -12.7000 5 N2x N 10.8365 -15.7661 6 C8y C 11.4377 -13.3216 7 C8y C 11.7239 -14.6887 8 C8x C 7.9201 -12.3102 9 C8x C 6.5797 -12.6978 10 C8y C 6.2449 -14.0530 11 C8x C 7.2508 -15.0200 12 C8x C 13.0535 -15.1253 13 C8x C 14.0965 -14.1920 14 C8x C 13.8104 -12.8249 15 C8x C 12.4806 -12.3883 16 X Cl 4.8817 -14.4470 17 N1y N 8.7986 -16.9892 18 C1x C 7.3986 -16.9892 19 C1x C 6.6986 -18.2016 20 N1x N 7.3986 -19.4141 21 C1x C 8.7986 -19.4141 22 C1x C 9.4986 -18.2016BOND 25 1 3 4 1 2 1 5 2 3 4 6 1 4 2 3 1 5 5 7 1 6 1 2 1 7 6 7 1 8 3 8 2 9 8 9 1 10 9 10 2 11 10 11 1 12 2 11 2 13 7 12 2 14 12 13 1 15 13 14 2 16 14 15 1 17 6 15 2 18 10 16 1 19 1 17 1 20 17 18 1 21 18 19 1 22 19 20 1 23 20 21 1 24 21 22 1 25 17 22 1 |
