| Name |
Lovastatin (USP/INN);MK-803;ML-530B;Mevacor (TN) |
| Product |
ALTOPREV (Covis Pharma US) |
| Generic |
LOVASTATIN (A-S Medication Solutions), LOVASTATIN (A-S Medication Solutions), LOVASTATIN (A-S Medication Solutions), LOVASTATIN (A-S Medication Solutions), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (Aphena Pharma Solutions - Tennessee), LOVASTATIN (BluePoint Laboratories), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Bryant Ranch Prepack), LOVASTATIN (Carlsbad Technology), LOVASTATIN (Golden State Medical Supply), LOVASTATIN (Legacy Pharmaceutical Packaging), LOVASTATIN (Lupin Pharmaceuticals), LOVASTATIN (NCS HealthCare of KY), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (Northwind Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (NuCare Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (PD-Rx Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Preferred Pharmaceuticals), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (Proficient Rx LP), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (REMEDYREPACK), LOVASTATIN (Teva Pharmaceuticals USA) |
| Formula |
C24H36O5 |
| Exact mass |
404.2563 |
| Mol weight |
404.54 |
| Structure |
 |
| Simcomp |
|
| Source |
Monascus ruber [TAX:89489], Aspergillus terreus [TAX:33178] |
| Class |
Hypolipidemic agent DG01946 Hypolipidemic agent DG01660 HMG-CoA reductase inhibitorMetabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate |
| Remark |
Same as: C07074ATC code: C10AA02Product: D00359 |
| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
| Disease |
Myocardial infarction [DS:H01730]Unstable angina [DS:H01632]Hyperlipidemia [DS:H01635] |
| Comment |
Active form of prodrug: Lovastatin acid [CPD:C21130] |
| Target |
HMGCR [HSA:3156] [KO:K00021] |
| Pathway |
hsa00900 Terpenoid backbone biosynthesis |
| Metabolism |
Enzyme: CYP3A4 [HSA:1576] |
| Interaction |
|
| Structure map |
map07024 HMG-CoA reductase inhibitors |
| Other map |
map04976 Bile secretion |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] C CARDIOVASCULAR SYSTEM C10 LIPID MODIFYING AGENTS C10A LIPID MODIFYING AGENTS, PLAIN C10AA HMG CoA reductase inhibitors C10AA02 Lovastatin D00359 Lovastatin (USP/INN) USP drug classification [BR:br08302] Cardiovascular Agents Dyslipidemics, HMG CoA Reductase Inhibitors Lovastatin D00359 Lovastatin (USP/INN)Drug groups [BR:br08330] Hypolipidemic agent DG01946 Hypolipidemic agent DG01660 HMG-CoA reductase inhibitor D00359 Lovastatin Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate D00359 LovastatinDrug classes [BR:br08332] Cardiovascular agent DG01946 Hypolipidemic agent D00359 LovastatinTarget-based classification of drugs [BR:br08310] Enzymes Oxidoreductases (EC1) Dehydrogenases HMGCR D00359 Lovastatin (USP/INN) Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00359Prodrugs [br08324.html] D00359 |
| Other DBs |
CAS: 75330-75-5PubChem: 7847425ChEBI: 40303PDB-CCD: 803[PDBj] LigandBox: D00359NIKKAJI: J22.276C |
| LinkDB |
|
| KCF data |
ATOM 29 1 C1y C 26.2681 -21.4649 2 C1y C 25.0617 -20.7655 3 C2y C 26.2624 -22.8577 4 C1y C 27.4745 -20.7713 5 O7a O 25.0617 -19.3726 6 C1x C 23.8497 -21.4649 7 C2x C 27.4628 -23.5627 8 C2x C 25.0617 -23.5570 9 C1b C 27.4803 -19.3785 10 C1y C 28.6808 -21.4766 11 C7a C 23.8555 -18.6733 12 C1y C 23.8497 -22.8577 13 C2x C 28.6750 -22.8694 14 C1c C 22.6491 -19.3726 15 O6a O 23.8613 -17.2805 16 C1a C 22.6433 -23.5570 17 C1b C 21.4427 -18.6733 18 C1a C 22.6491 -20.7655 19 C1a C 20.2364 -19.3669 20 C1a C 29.8734 -20.7959 21 C1b C 28.7139 -18.6619 22 C1y C 28.7173 -17.2654 23 O7x O 29.9266 -16.5712 24 C7x C 29.9300 -15.1747 25 C1x C 28.7223 -14.4735 26 C1y C 27.5132 -15.1677 27 C1x C 27.5097 -16.5641 28 O6a O 31.1392 -14.4805 29 O1a O 26.2978 -14.4619BOND 31 1 1 2 1 2 1 3 1 3 1 4 1 4 2 5 1 #Down 5 2 6 1 6 3 7 1 7 3 8 2 8 4 9 1 #Up 9 4 10 1 10 5 11 1 11 6 12 1 12 7 13 2 13 11 14 1 14 11 15 2 15 12 16 1 #Down 16 14 17 1 17 14 18 1 #Up 18 17 19 1 19 8 12 1 20 10 13 1 21 10 20 1 #Up 22 9 21 1 23 22 21 1 #Down 24 22 23 1 25 23 24 1 26 24 25 1 27 25 26 1 28 26 27 1 29 22 27 1 30 24 28 2 31 26 29 1 #Up |
