| Name |
Lorazepam (JP18/USP/INN);Ativan (TN) |
| Product |
ATIVAN (Bausch Health US LLC), ATIVAN (Hikma Pharmaceuticals USA), LORAZEPAM (Civica), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (Hikma Pharmaceuticals USA), LOREEV XR (Almatica Pharma LLC) |
| Generic |
LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (A-S Medication Solutions), LORAZEPAM (ANI Pharmaceuticals), LORAZEPAM (Advanced Rx of Tennessee), LORAZEPAM (American Health Packaging), LORAZEPAM (Amneal Pharmaceuticals LLC), LORAZEPAM (Amneal Pharmaceuticals LLC), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Aphena Pharma Solutions - Tennessee), LORAZEPAM (Asclemed USA), LORAZEPAM (Asclemed USA), LORAZEPAM (Aurolife Pharma LLC), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Bryant Ranch Prepack), LORAZEPAM (Cardinal Health 107), LORAZEPAM (Chartwell RX), LORAZEPAM (Chartwell RX), LORAZEPAM (Clinical Solutions Wholesale), LORAZEPAM (DIRECT RX), LORAZEPAM (DirectRx), LORAZEPAM (Direct_Rx), LORAZEPAM (Fresenius Kabi USA), LORAZEPAM (Hikma Pharmaceuticals USA), LORAZEPAM (Hospira), LORAZEPAM (International Medication Systems), LORAZEPAM (Leading Pharma), LORAZEPAM (Major Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (NuCare Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PD-Rx Pharmaceuticals), LORAZEPAM (PharmPak), LORAZEPAM (Pharmaceutical Associates), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Preferred Pharmaceuticals), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (Proficient Rx LP), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (REMEDYREPACK), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (RedPharm Drug), LORAZEPAM (SUN PHARMACEUTICAL INDUSTRIES), LORAZEPAM (Teva Pharmaceuticals USA) |
| Formula |
C15H10Cl2N2O2 |
| Exact mass |
320.0119 |
| Mol weight |
321.15 |
| Structure |
 |
| Simcomp |
|
| Class |
Neuropsychiatric agent DG01567 GABA-A receptor agonist DG01914 Anxiolytics, benzodiazepine derivatives DG03199 Antiepileptic agentMetabolizing enzyme substrate DG02924 UGT substrate DG03190 UGT2B7 substrate DG03187 UGT2B15 substrate |
| Remark |
Therapeutic category: 1124 1139ATC code: N05BA06Product: D00365<JP/US> |
| Efficacy |
Antianxiety, Anticonvulsant, Minor tranquilizer |
| Comment |
Benzodiazepine derivative |
| Target |
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192] |
| Pathway |
hsa04080 Neuroactive ligand-receptor interactionhsa04727 GABAergic synapse |
| Metabolism |
Enzyme: UGT2B7 [HSA:7364], UGT2B15 [HSA:7366] |
| Interaction |
|
| Structure map |
map07030 Anxiolyticsmap07230 GABA-A receptor agonists/antagonists |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N05 PSYCHOLEPTICS N05B ANXIOLYTICS N05BA Benzodiazepine derivatives N05BA06 Lorazepam D00365 Lorazepam (JP18/USP/INN) <JP/US>USP drug classification [BR:br08302] Anticonvulsants Gamma-aminobutyric Acid (GABA) Augmenting Agents Benzodiazepines Lorazepam D00365 Lorazepam (JP18/USP/INN) Anxiolytics Benzodiazepines Lorazepam D00365 Lorazepam (JP18/USP/INN)Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 112 Hypnotics and sedatives, anxiolytics 1124 Benzodiazepins D00365 Lorazepam (JP18/USP/INN) 113 Antiepileptics 1139 Others D00365 Lorazepam (JP18/USP/INN)Drug groups [BR:br08330] Neuropsychiatric agent DG01567 GABA-A receptor agonist D00365 Lorazepam DG01914 Anxiolytics, benzodiazepine derivatives D00365 Lorazepam DG03199 Antiepileptic agent D00365 Lorazepam Metabolizing enzyme substrate DG02924 UGT substrate DG03190 UGT2B7 substrate D00365 Lorazepam DG03187 UGT2B15 substrate D00365 LorazepamDrug classes [BR:br08332] Neuropsychiatric agent DG03199 Antiepileptic agent D00365 LorazepamTarget-based classification of drugs [BR:br08310] Ion channels Ligand-gated ion channels GABA (ionotropic) GABR D00365 Lorazepam (JP18/USP/INN) <JP/US>Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00365 LorazepamDrug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00365Narcotics and psychotropics in Japan [br08308.html] Psychotropics by Cabinet order Article 3 (78 substances) D00365 |
| Other DBs |
CAS: 846-49-1PubChem: 7847431ChEBI: 6539LigandBox: D00365NIKKAJI: J3.337E |
| LinkDB |
|
| KCF data |
ATOM 21 1 C2y C 19.5808 -11.8131 2 C8y C 18.7361 -10.7001 3 C8y C 19.0723 -9.3392 4 N1x N 20.3372 -8.7593 5 N2x N 20.9909 -11.8384 6 C5x C 21.5946 -9.3835 7 C1y C 21.8820 -10.7564 8 C8x C 18.0621 -8.3678 9 C8x C 16.7160 -8.7571 10 C8y C 16.3798 -10.1180 11 C8x C 17.3900 -11.0891 12 O1a O 23.2172 -11.1948 13 O5x O 22.6419 -8.4462 14 X Cl 15.0268 -10.5091 15 C8y C 18.8591 -13.0128 16 C8x C 17.4591 -13.0128 17 C8x C 16.7591 -14.2252 18 C8x C 17.4591 -15.4377 19 C8x C 18.8591 -15.4377 20 C8y C 19.5591 -14.2252 21 X Cl 20.9299 -14.2249BOND 23 1 3 4 1 2 1 5 2 3 4 6 1 4 2 3 1 5 5 7 1 6 1 2 1 7 6 7 1 8 3 8 2 9 8 9 1 10 9 10 2 11 10 11 1 12 2 11 2 13 7 12 1 14 6 13 2 15 10 14 1 16 1 15 1 17 15 16 1 18 16 17 2 19 17 18 1 20 18 19 2 21 19 20 1 22 15 20 2 23 20 21 1 |
