| Name |
Ondansetron (JAN/USP/INN);Zofran ODT (TN) |
| Product |
|
| Generic |
ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (A-S Medication Solutions), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (Advanced Rx Pharmacy of Tennessee), ONDANSETRON (Asclemed USA), ONDANSETRON (Asclemed USA), ONDANSETRON (Aurobindo Pharma Limited), ONDANSETRON (BluePoint Laboratories), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Bryant Ranch Prepack), ONDANSETRON (Cardinal Health 107), ONDANSETRON (Chartwell RX), ONDANSETRON (DIRECT RX), ONDANSETRON (Denton Pharma), ONDANSETRON (Denton Pharma), ONDANSETRON (Direct Rx), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (HF Acquisition Co LLC), ONDANSETRON (Lake Erie Medical DBA Quality Care Products LLC), ONDANSETRON (Lifsa Drugs LLC), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON (Medsource Pharmaceuticals), ONDANSETRON (NorthStar Rx LLC), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (Northwind Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (NuCare Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (PD-Rx Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Preferred Pharmaceuticals), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Proficient Rx LP), ONDANSETRON (Quality Care Products LLC), ONDANSETRON (REMEDYREPACK), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RPK Pharmaceuticals), ONDANSETRON (RedPharm Drug), ONDANSETRON (Redpharm Drug), ONDANSETRON (Redpharm Drug), ONDANSETRON (Rising Pharma Holdings), ONDANSETRON (ST. MARY'S MEDICAL PARK PHARMACY), ONDANSETRON (St Marys Medical Park Pharmacy), ONDANSETRON (St. Mary's Medical Park Pharmacy), ONDANSETRON HYDROCHLORIDE (Bryant Ranch Prepack) |
| Formula |
C18H19N3O |
| Exact mass |
293.1528 |
| Mol weight |
293.36 |
| Structure |
 |
| Simcomp |
|
| Class |
Gastrointestinal agent DG01489 5-HT3-receptor antagonist DG01762 AntiemeticMetabolizing enzyme substrate DG01892 CYP1A2 substrate DG01644 CYP2D6 substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate |
| Remark |
Same as: C07325ATC code: A04AA01Chemical structure group: DG00060Product (DG00060): D00456 D00678<JP/US> |
| Efficacy |
Anti-emetic, Serotonin 5-HT3 receptor antagonist |
| Target |
HTR3 [HSA:3359 9177 170572 200909 285242] [KO:K04819] |
| Pathway |
hsa04726 Serotonergic synapse |
| Metabolism |
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565] |
| Interaction |
|
| Structure map |
map07211 Serotonin receptor agonists/antagonists |
| Other map |
map04976 Bile secretion |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A04 ANTIEMETICS AND ANTINAUSEANTS A04A ANTIEMETICS AND ANTINAUSEANTS A04AA Serotonin (5HT3) antagonists A04AA01 Ondansetron D00456 Ondansetron (JAN/USP/INN) USP drug classification [BR:br08302] Antiemetics Emetogenic Therapy Adjuncts Ondansetron D00456 Ondansetron (JAN/USP/INN)Drug groups [BR:br08330] Gastrointestinal agent DG01489 5-HT3-receptor antagonist DG00060 Ondansetron D00456 Ondansetron DG01762 Antiemetic DG00060 Ondansetron D00456 Ondansetron Metabolizing enzyme substrate DG01892 CYP1A2 substrate DG00060 Ondansetron D00456 Ondansetron DG01644 CYP2D6 substrate DG00060 Ondansetron D00456 Ondansetron DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00060 Ondansetron D00456 OndansetronTarget-based classification of drugs [BR:br08310] Ion channels Ligand-gated ion channels Serotonin HTR3 D00456 Ondansetron (JAN/USP/INN) Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00456Drug groups [BR:br08330] Gastrointestinal agent DG01489 5-HT3-receptor antagonist DG00060 Ondansetron DG01762 Antiemetic DG00060 Ondansetron Metabolizing enzyme substrate DG01892 CYP1A2 substrate DG00060 Ondansetron DG01644 CYP2D6 substrate DG00060 Ondansetron DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00060 Ondansetron |
| Other DBs |
CAS: 99614-02-5PubChem: 7847522ChEBI: 7773PDB-CCD: S87[PDBj] LigandBox: D00456NIKKAJI: J245.610I |
| LinkDB |
|
| KCF data |
ATOM 22 1 C8y C 33.5159 -17.7325 2 C8y C 34.8490 -18.1807 3 C8y C 33.5217 -16.3295 4 C5x C 32.3109 -18.4368 5 C8y C 35.6698 -17.0396 6 C8x C 35.4254 -19.4557 7 N4y N 34.8607 -15.9044 8 C1x C 32.3109 -15.6367 9 C1y C 31.0941 -17.7325 10 O5x O 32.3166 -19.8341 11 C8x C 37.0613 -17.1794 12 C8x C 36.8167 -19.5896 13 C1a C 35.2972 -14.5771 14 C1x C 31.0941 -16.3295 15 C1b C 29.8831 -18.4368 16 C8x C 37.6318 -18.4544 17 N4y N 28.6780 -17.7325 18 C8y C 28.7203 -16.3253 19 C8x C 27.3348 -18.1219 20 N5x N 27.3985 -15.8508 21 C1a C 29.8791 -15.5437 22 C8x C 26.5473 -16.9625BOND 25 1 1 2 1 2 1 3 2 3 1 4 1 4 2 5 1 5 2 6 2 6 3 7 1 7 3 8 1 8 4 9 1 9 4 10 2 10 5 11 2 11 6 12 1 12 7 13 1 13 8 14 1 14 9 15 1 15 11 16 1 16 15 17 1 17 17 18 1 18 17 19 1 19 18 20 2 20 18 21 1 21 19 22 2 22 5 7 1 23 9 14 1 24 12 16 2 25 20 22 1 |
