| Name |
Propofol (JAN/USP/INN);Diprivan (TN) |
| Product |
DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA) |
| Generic |
PROPOFOL (Amneal Pharmaceuticals Private Limited), PROPOFOL (Avenacy), PROPOFOL (Civica), PROPOFOL (HF Acquisition Co LLC), PROPOFOL (HF Acquisition Co LLC), PROPOFOL (HF Acquisition Co LLC), PROPOFOL (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), PROPOFOL (Hikma Pharmaceuticals USA), PROPOFOL (Hospira), PROPOFOL (NorthStar Rx LLC), PROPOFOL (Pfizer Laboratories Div Pfizer), PROPOFOL (Sagent Pharmaceuticals), PROPOFOL INJECTABLE EMULSION (Dr. Reddy's Laboratories) |
| Formula |
C12H18O |
| Exact mass |
178.1358 |
| Mol weight |
178.27 |
| Structure |
 |
| Simcomp |
|
| Class |
Neuropsychiatric agent DG01567 GABA-A receptor agonist DG02030 Anesthetics DG02027 General anesthetics |
| Remark |
Same as: C07523Therapeutic category: 1119ATC code: N01AX10Chemical structure group: DG00797Product (DG00797): D00549<JP/US> |
| Efficacy |
Anesthetic (intravenous), GABA-A receptor agonist |
| Comment |
Isopropylphenol derivative |
| Target |
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192] |
| Pathway |
hsa04080 Neuroactive ligand-receptor interactionhsa04727 GABAergic synapse |
| Interaction |
|
| Structure map |
map07230 GABA-A receptor agonists/antagonists |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N01 ANESTHETICS N01A ANESTHETICS, GENERAL N01AX Other general anesthetics N01AX10 Propofol D00549 Propofol (JAN/USP/INN) <JP/US>Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 111 General anesthetics 1119 Others D00549 Propofol (JAN/USP/INN)Drug groups [BR:br08330] Neuropsychiatric agent DG01567 GABA-A receptor agonist DG00797 Propofol D00549 Propofol DG02030 Anesthetics DG02027 General anesthetics DG00797 Propofol D00549 PropofolTarget-based classification of drugs [BR:br08310] Ion channels Ligand-gated ion channels GABA (ionotropic) GABR D00549 Propofol (JAN/USP/INN) <JP/US>Prodrugs [br08324.html] D00549Drug groups [BR:br08330] Neuropsychiatric agent DG01567 GABA-A receptor agonist DG00797 Propofol DG02030 Anesthetics DG02027 General anesthetics DG00797 Propofol |
| Other DBs |
CAS: 2078-54-8PubChem: 7847615ChEBI: 44915PDB-CCD: PFL[PDBj] LigandBox: D00549NIKKAJI: J102.606B |
| LinkDB |
|
| KCF data |
ATOM 13 1 C8y C 24.1226 -18.3979 2 C8y C 25.3400 -17.6989 3 C1c C 22.9112 -17.6989 4 C8x C 24.1226 -19.7958 5 C8y C 26.5514 -18.3979 6 O1a O 25.3457 -16.3010 7 C1a C 22.9112 -16.3010 8 C1a C 21.6996 -18.3979 9 C8x C 25.3400 -20.5005 10 C1c C 27.7688 -17.6989 11 C8x C 26.5514 -19.7958 12 C1a C 28.9804 -18.3979 13 C1a C 27.7688 -16.3010BOND 13 1 1 2 1 2 1 3 1 3 1 4 2 4 2 5 2 5 2 6 1 6 3 7 1 7 3 8 1 8 4 9 1 9 5 10 1 10 5 11 1 11 10 12 1 12 10 13 1 13 9 11 2 |
