| Name |
Mequitazine (JP18/INN);Kitazemin (TN) |
| Formula |
C20H22N2S |
| Exact mass |
322.1504 |
| Mol weight |
322.47 |
| Structure |
 |
| Simcomp |
|
| Class |
Anti-allergic agent DG01557 Histamine receptor antagonist DG01482 Histamine receptor H1 antagonistDermatological agent DG03243 Atopic dermatitis agentMetabolizing enzyme substrate DG01644 CYP2D6 substrate |
| Remark |
Same as: C12755Therapeutic category: 4413ATC code: R06AD07Product: D01324<JP> |
| Efficacy |
Antiallergic, Antiasthmatic, H1 receptor antagonist |
| Comment |
Phenothiazine derivative |
| Target |
HRH1 [HSA:3269] [KO:K04149] |
| Pathway |
hsa04020 Calcium signaling pathwayhsa04080 Neuroactive ligand-receptor interaction |
| Metabolism |
Enzyme: CYP2D6 [HSA:1565] |
| Interaction |
|
| Structure map |
map07212 Histamine H1 receptor antagonists |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] R RESPIRATORY SYSTEM R06 ANTIHISTAMINES FOR SYSTEMIC USE R06A ANTIHISTAMINES FOR SYSTEMIC USE R06AD Phenothiazine derivatives R06AD07 Mequitazine D01324 Mequitazine (JP18/INN) Therapeutic category of drugs in Japan [BR:br08301] 4 Agents affecting cellular function 44 Allergic agents 441 Antihistamines 4413 Phenothiazines D01324 Mequitazine (JP18/INN)Classification of Japanese OTC drugs [BR:br08313] Agents for nervous and sensory systems 01 Cold remedy (oral use) D01324 Mequitazine (JP18/INN) Allergic agents 52 Antihistamine based drugs D01324 Mequitazine (JP18/INN) Agents for otolaryngologic use 69 Oral medicine for nasal inflammation D01324 Mequitazine (JP18/INN)Risk category of Japanese OTC drugs [BR:br08312] Second-class OTC drugs Inorganic and organic chemicals Mequitazine D01324 Mequitazine (JP18/INN)Drug groups [BR:br08330] Anti-allergic agent DG01557 Histamine receptor antagonist DG01482 Histamine receptor H1 antagonist D01324 Mequitazine Dermatological agent DG03243 Atopic dermatitis agent D01324 Mequitazine Metabolizing enzyme substrate DG01644 CYP2D6 substrate D01324 MequitazineDrug classes [BR:br08332] Anti-allergic agent DG01482 Histamine receptor H1 antagonist D01324 Mequitazine Dermatological agent DG03243 Atopic dermatitis agent D01324 MequitazineTarget-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Histamine HRH1 D01324 Mequitazine (JP18/INN) Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D01324 Mequitazine D01324 Mequitazine tabletsDrug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D01324Rx-to-OTC switch list in Japan [br08314.html] D01324 |
| Other DBs |
CAS: 29216-28-2PubChem: 7848387ChEBI: 31821LigandBox: D01324NIKKAJI: J342.305K |
| LinkDB |
|
| KCF data |
ATOM 23 1 C1x C 23.4130 -15.6918 2 N1y N 24.8526 -14.8141 3 C1y C 22.6816 -14.6444 4 C1x C 24.8526 -13.5735 5 C1x C 26.3564 -15.6216 6 C1y C 24.0978 -13.8077 7 C1x C 24.1035 -12.8187 8 C1x C 25.6602 -14.5097 9 C8x C 17.8213 -17.4339 10 C8x C 17.8213 -18.8339 11 C8x C 19.0367 -19.5339 12 C8x C 19.0367 -16.7339 13 C8y C 20.2449 -17.4339 14 C8y C 20.2388 -18.8339 15 S2x S 21.4483 -19.5392 16 N1y N 21.4603 -16.7392 17 C8y C 22.6698 -17.4443 18 C8y C 22.6570 -18.8407 19 C8x C 23.8600 -19.5497 20 C8x C 25.0756 -18.8626 21 C8x C 25.0883 -17.4662 22 C8x C 23.8853 -16.7572 23 C1b C 21.4663 -15.3392BOND 27 1 10 11 2 2 11 14 1 3 13 12 1 4 12 9 2 5 2 5 1 6 3 6 1 7 4 7 1 8 5 8 1 9 13 14 2 10 14 15 1 11 15 18 1 12 17 16 1 13 16 13 1 14 6 7 1 15 6 8 1 16 1 2 1 17 1 3 1 18 2 4 1 19 17 18 2 20 18 19 1 21 19 20 2 22 20 21 1 23 21 22 2 24 22 17 1 25 9 10 1 26 16 23 1 27 23 3 1 |
