| Name |
Tadalafil (JAN/USP/INN);Adcirca (TN);Cialis (TN);Zalutia (TN) |
| Product |
ADCIRCA (United Therapeutics Corporation), CIALIS (Eli Lilly and Company), TADLIQ (CMP Pharma) |
| Generic |
ALYQ (AvKARE), ALYQ (Teva Pharmaceuticals USA), ALYQ (Teva Pharmaceuticals), TADALAFIL (A-S Medication Solutions), TADALAFIL (A-S Medication Solutions), TADALAFIL (A-S Medication Solutions), TADALAFIL (A-S Medication Solutions), TADALAFIL (A-S Medication Solutions), TADALAFIL (A-S Medication Solutions), TADALAFIL (ANI Pharmaceuticals), TADALAFIL (Accord Healthcare), TADALAFIL (Ajanta Pharma USA), TADALAFIL (Ajanta Pharma USA), TADALAFIL (Alembic Pharmaceuticals Limited), TADALAFIL (Alembic Pharmaceuticals), TADALAFIL (Amneal Pharmaceuticals NY LLC), TADALAFIL (Amneal Pharmaceuticals NY LLC), TADALAFIL (Aphena Pharma Solutions - Tennessee), TADALAFIL (Aphena Pharma Solutions - Tennessee), TADALAFIL (Aphena Pharma Solutions - Tennessee), TADALAFIL (Aphena Pharma Solutions - Tennessee), TADALAFIL (Aphena Pharma Solutions - Tennessee), TADALAFIL (Aphena Pharma Solutions - Tennessee), TADALAFIL (Asclemed USA), TADALAFIL (Asclemed USA), TADALAFIL (Asclemed USA), TADALAFIL (Asclemed USA), TADALAFIL (Asclemed USA), TADALAFIL (Aurobindo Pharma Limited), TADALAFIL (Aurobindo Pharma Limited), TADALAFIL (AvKARE), TADALAFIL (AvPAK), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Bryant Ranch Prepack), TADALAFIL (Burel Pharmaceuticals), TADALAFIL (Burel Pharmaceuticals), TADALAFIL (Camber Pharmaceuticals), TADALAFIL (Camber Pharmaceuticals), TADALAFIL (Cipla USA), TADALAFIL (Cipla USA), TADALAFIL (Direct_Rx), TADALAFIL (Direct_Rx), TADALAFIL (Dr.Reddys Laboratories), TADALAFIL (Dr.Reddys Laboratories), TADALAFIL (ECI Pharmaceuticals), TADALAFIL (FOURRTS (INDIA) LABORATORIES PRIVATE LIMITED), TADALAFIL (Lupin Pharmaceuticals), TADALAFIL (Lupin Pharmaceuticals), TADALAFIL (Macleods Pharmaceuticals Limited), TADALAFIL (Macleods Pharmaceuticals Limited), TADALAFIL (Medsource Pharmaceuticals), TADALAFIL (NIVAGEN PHARMACEUTICALS), TADALAFIL (NUCARE PHARMACEUTICALS), TADALAFIL (NorthStar RxLLC), TADALAFIL (Northwind Pharmaceuticals), TADALAFIL (Northwind Pharmaceuticals), TADALAFIL (Northwind Pharmaceuticals), TADALAFIL (Northwind Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (NuCare Pharmaceuticals), TADALAFIL (PD-RX Pharmaceuticals), TADALAFIL (PD-Rx Pharmaceuticals), TADALAFIL (PD-Rx Pharmaceuticals), TADALAFIL (PD-Rx Pharmaceuticals), TADALAFIL (PD-Rx Pharmaceuticals), TADALAFIL (PD-Rx Pharmaceuticals), TADALAFIL (PD-Rx Pharmaceuticals), TADALAFIL (PD-Rx Pharmaceuticals), TADALAFIL (Preferred Pharmaceuticals), TADALAFIL (Preferred Pharmaceuticals), TADALAFIL (Preferred Pharmaceuticals), TADALAFIL (Preferred Pharmaceuticals), TADALAFIL (Preferred Pharmaceuticals), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Proficient Rx LP), TADALAFIL (Qilu Pharmaceutical), TADALAFIL (Quallent Pharmaceuticals Health LLC), TADALAFIL (Quallent Pharmaceuticals Health LLC), TADALAFIL (REMEDYREPACK), TADALAFIL (REMEDYREPACK), TADALAFIL (REMEDYREPACK), TADALAFIL (REMEDYREPACK), TADALAFIL (REMEDYREPACK), TADALAFIL (REMEDYREPACK), TADALAFIL (REMEDYREPACK), TADALAFIL (Solco Healthcare US), TADALAFIL (Solco Healthcare US), TADALAFIL (Sun Pharmaceutical Industries), TADALAFIL (TWi Pharmaceuticals), TADALAFIL (Teva Pharmaceuticals USA), TADALAFIL (Teva Pharmaceuticals), TADALAFIL (Torrent Pharmaceuticals Limited), TADALAFIL (Torrent Pharmaceuticals Limited), TADALAFIL (Unichem Pharmaceuticals (USA)), TADALAFIL (VKT Pharma Private Limited), TADALAFIL (Zydus Lifesciences Limited), TADALAFIL (Zydus Pharmaceuticals USA), TADALAFIL (direct rx), TADALAFIL (medsource pharmaceuticals) |
| Formula |
C22H19N3O4 |
| Exact mass |
389.1376 |
| Mol weight |
389.40 |
| Structure |
 |
| Class |
Cardiovascular agent DG01509 Phosphodiesterase V inhibitorMetabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate |
| Remark |
Therapeutic category: 2190 2590ATC code: G04BE08Product: D02008<JP/US> Product (mixture): D12486<US> |
| Efficacy |
Antihypertensive, Impotence therapy, Phosphodiesterase V inhibitor |
| Disease |
Pulmonary arterial hypertension [DS:H01621] |
| Comment |
Treatment of male erectile and female sexual dysfunction |
| Target |
PDE5 [HSA:8654] [KO:K13762] |
| Pathway |
hsa00230 Purine metabolism |
| Metabolism |
Enzyme: CYP3A4 [HSA:1576] |
| Interaction |
|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] G GENITO URINARY SYSTEM AND SEX HORMONES G04 UROLOGICALS G04B UROLOGICALS G04BE Drugs used in erectile dysfunction G04BE08 Tadalafil D02008 Tadalafil (JAN/USP/INN) <JP/US>USP drug classification [BR:br08302] Genitourinary Agents Benign Prostatic Hypertrophy Agents Tadalafil D02008 Tadalafil (JAN/USP/INN) Respiratory Tract/Pulmonary Agents Pulmonary Antihypertensives Phosphodiesterase-5 (PDE5) Inhibitors Tadalafil D02008 Tadalafil (JAN/USP/INN) Sexual Disorder Agents Sexual Disorder Agents (Male) Tadalafil D02008 Tadalafil (JAN/USP/INN)Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 219 Miscellaneous 2190 Miscellaneous D02008 Tadalafil (JAN/USP/INN) 25 Urogenital and anal organ agents 259 Miscellaneous 2590 Miscellaneous D02008 Tadalafil (JAN/USP/INN)Drug groups [BR:br08330] Cardiovascular agent DG01509 Phosphodiesterase V inhibitor D02008 Tadalafil Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate D02008 TadalafilTarget-based classification of drugs [BR:br08310] Enzymes Hydrolases (EC3) Phosphodiesterases PDE5 D02008 Tadalafil (JAN/USP/INN) <JP/US>New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D02008New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D02008New drug approvals in Japan [br08318.html] Drugs with new active ingredients D02008New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D02008Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D02008 |
| Other DBs |
CAS: 171596-29-5PubChem: 7849070ChEBI: 71940PDB-CCD: CIA[PDBj] LigandBox: D02008NIKKAJI: J1.662.659G |
| LinkDB |
|
| KCF data |
ATOM 29 1 N1y N 29.4582 -12.6733 2 C1x C 30.1741 -13.7777 3 C5x C 29.5963 -15.0632 4 N1y N 28.2326 -15.0448 5 C1y C 27.4708 -14.1585 6 C5x C 28.0566 -12.6389 7 C1y C 27.6549 -16.4236 8 C8y C 26.2912 -16.4518 9 C1x C 26.1152 -14.1159 10 C8y C 25.5294 -15.3555 11 O5x O 27.2788 -11.5908 12 O5x O 30.4201 -16.2432 13 C8y C 28.4706 -17.5343 14 C8x C 29.8722 -17.4755 15 C8x C 30.6960 -18.6089 16 C8y C 30.0724 -19.9725 17 C8y C 28.6250 -19.9694 18 C8x C 27.8471 -18.8281 19 O2x O 30.5829 -21.1851 20 C1x C 29.5192 -22.1306 21 O2x O 28.3012 -21.3988 22 C1a C 30.0900 -11.4256 23 C8y C 24.1928 -15.8284 24 C8y C 24.2058 -17.2380 25 N4x N 25.5595 -17.6699 26 C8x C 22.9827 -15.1426 27 C8x C 21.7866 -15.8747 28 C8x C 21.8003 -17.2924 29 C8x C 23.0561 -17.9701BOND 34 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 4 7 1 8 7 8 1 9 5 9 1 10 10 8 2 11 9 10 1 12 6 11 2 13 3 12 2 14 7 13 1 #Down 15 13 14 2 16 14 15 1 17 15 16 2 18 16 17 1 19 17 18 2 20 13 18 1 21 16 19 1 22 19 20 1 23 20 21 1 24 17 21 1 25 1 22 1 26 10 23 1 27 23 24 1 28 24 25 1 29 25 8 1 30 23 26 2 31 26 27 1 32 27 28 2 33 28 29 1 34 24 29 2 |
