| Name |
Nicotine (USP);Habitrol (TN) |
| Product |
NICOTROL (Pharmacia & Upjohn Company LLC), NICOTROL (Pharmacia & Upjohn Company LLC) |
| Formula |
C10H14N2 |
| Exact mass |
162.1157 |
| Mol weight |
162.23 |
| Structure |
 |
| Simcomp |
|
| Class |
Metabolizing enzyme substrate DG01638 CYP2A6 substrateMetabolizing enzyme inducer DG01637 CYP1A2 inducer |
| Remark |
Same as: C00745Therapeutic category: 7990ATC code: N07BA01Chemical structure group: DG00994Product (DG00994): D03365<JP/US> |
| Efficacy |
Smoking cessation adjunct |
| Target |
CHRN [HSA:1134 1135 1136 1137 1138 8973 1139 55584 57053 1140 1141 1142 1143 1144 1145 1146] [KO:K04803 K04804 K04805 K04806 K04807 K04808 K04809 K04810 K04811 K04812 K04813 K04814 K04815 K04816 K04817 K04818] |
| Pathway |
hsa04080 Neuroactive ligand-receptor interactionhsa04725 Cholinergic synapsehsa05033 Nicotine addiction |
| Metabolism |
Enzyme: CYP2A6 [HSA:1548] |
| Interaction |
CYP induction: CYP1A2 [HSA:1544] |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N07 OTHER NERVOUS SYSTEM DRUGS N07B DRUGS USED IN ADDICTIVE DISORDERS N07BA Drugs used in nicotine dependence N07BA01 Nicotine D03365 Nicotine (USP) <JP/US>USP drug classification [BR:br08302] Anti-Addiction/Substance Abuse Treatment Agents Smoking Cessation Agents Nicotine D03365 Nicotine (USP)Therapeutic category of drugs in Japan [BR:br08301] 7 Agents not mainly for therapeutic purpose 79 Other agents not mainly for therapeutic purpose 799 Miscellaneous 7990 Miscellaneous D03365 Nicotine (USP)Classification of Japanese OTC drugs [BR:br08313] Stop smoking aid 77 Stop smoking aid D03365 Nicotine (USP)Risk category of Japanese OTC drugs [BR:br08312] First-class OTC drugs Inorganic and organic chemicals Nicotine D03365 Nicotine (USP) Designated second-class OTC drugs Inorganic and organic chemicals Nicotine D03365 Nicotine (USP) Second-class OTC drugs Inorganic and organic chemicals Nicotine D03365 Nicotine (USP)Drug groups [BR:br08330] Metabolizing enzyme substrate DG01638 CYP2A6 substrate DG00994 Nicotine D03365 Nicotine Metabolizing enzyme inducer DG01637 CYP1A2 inducer DG00994 Nicotine D03365 NicotineTarget-based classification of drugs [BR:br08310] Ion channels Ligand-gated ion channels Acetylcholine (nicotinic) CHRN D03365 Nicotine (USP) <JP/US>Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D03365Rx-to-OTC switch list in the USA [br08315.html] D03365Rx-to-OTC switch list in Japan [br08314.html] D03365Drug groups [BR:br08330] Metabolizing enzyme substrate DG01638 CYP2A6 substrate DG00994 Nicotine Metabolizing enzyme inducer DG01637 CYP1A2 inducer DG00994 Nicotine |
| Other DBs |
CAS: 54-11-5PubChem: 17397514ChEBI: 17688PDB-CCD: NCT[PDBj] LigandBox: D03365NIKKAJI: J9.266E |
| LinkDB |
|
| KCF data |
ATOM 12 1 C8x C 29.1341 -17.6496 2 C8x C 29.1341 -19.0503 3 N5x N 30.3471 -19.7507 4 C8x C 31.5602 -19.0503 5 C8y C 31.5602 -17.6496 6 C8x C 30.3471 -16.9493 7 C1y C 32.7920 -16.9383 8 C1x C 34.1270 -17.3204 9 C1x C 34.9074 -16.1695 10 C1x C 34.0540 -15.0718 11 N1y N 32.7463 -15.5441 12 C1a C 31.5702 -14.7465BOND 13 1 1 2 2 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 2 6 1 6 1 7 7 5 1 #Up 8 7 8 1 9 8 9 1 10 9 10 1 11 10 11 1 12 7 11 1 13 11 12 1 |
