| Name |
Edoxaban (USAN/INN) |
| Formula |
C24H30ClN7O4S |
| Exact mass |
547.1769 |
| Mol weight |
548.06 |
| Structure |
 |
| Class |
Blood modifier agent DG01950 Antithrombotic agent DG01662 Factor Xa inhibitor DG03320 Direct oral anticoagulant (DOAC)Transporter substrate DG01665 ABCB1 substrate |
| Remark |
ATC code: B01AF03Chemical structure group: DG01398Product (DG01398): D09546<JP/US> |
| Efficacy |
Antithrombotic, Factor Xa inhibitor |
| Target |
F10 [HSA:2159] [KO:K01314] |
| Pathway |
hsa04610 Complement and coagulation cascades |
| Metabolism |
Transporter: ABCB1 [HSA:5243] |
| Interaction |
|
| Structure map |
map07049 Antithrombosis agents |
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] B BLOOD AND BLOOD FORMING ORGANS B01 ANTITHROMBOTIC AGENTS B01A ANTITHROMBOTIC AGENTS B01AF Direct factor Xa inhibitors B01AF03 Edoxaban D09710 Edoxaban (USAN/INN)Drug groups [BR:br08330] Blood modifier agent DG01950 Antithrombotic agent DG01662 Factor Xa inhibitor DG01398 Edoxaban D09710 Edoxaban DG03320 Direct oral anticoagulant (DOAC) DG01398 Edoxaban D09710 Edoxaban Transporter substrate DG01665 ABCB1 substrate DG01398 Edoxaban D09710 EdoxabanTarget-based classification of drugs [BR:br08310] Peptidases and inhibitors Serine peptidases Chymotrypsin family F10 D09710 Edoxaban (USAN/INN)New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D09710Drug metabolizing enzymes and transporters [br08309.html] Drug transporters D09710Drug groups [BR:br08330] Blood modifier agent DG01950 Antithrombotic agent DG01662 Factor Xa inhibitor DG01398 Edoxaban DG03320 Direct oral anticoagulant (DOAC) DG01398 Edoxaban Transporter substrate DG01665 ABCB1 substrate DG01398 Edoxaban |
| Other DBs |
CAS: 480449-70-5PubChem: 124490450ChEBI: 85973LigandBox: D09710 |
| LinkDB |
|
| KCF data |
ATOM 37 1 C1x C 19.6700 -24.9200 2 C1y C 19.6700 -26.3200 3 C1y C 20.9300 -27.0200 4 C1x C 22.1200 -26.3200 5 C1x C 22.1200 -24.9200 6 C1y C 20.9300 -24.2200 7 C5a C 20.9300 -22.8200 8 O5a O 19.6700 -22.1200 9 N1c N 22.1200 -22.1200 10 C1a C 23.3100 -22.8200 11 C1a C 22.1200 -20.7200 12 N1b N 20.9300 -28.4900 13 C5a C 22.1200 -29.1200 14 C5a C 23.3100 -28.4900 15 O5a O 22.1200 -30.5900 16 N1b N 24.5000 -29.1200 17 O5a O 23.3100 -27.0200 18 C8y C 25.6900 -28.4900 19 N5x N 26.8800 -29.1200 20 C8x C 28.0700 -28.4200 21 C8y C 28.0700 -27.0200 22 C8x C 26.8800 -26.3200 23 C8x C 25.6900 -27.0900 24 X Cl 29.3300 -26.3200 25 N1b N 18.4800 -27.0200 26 C5a C 17.2900 -26.3900 27 C8y C 16.1000 -27.0200 28 O5a O 17.2900 -24.9200 29 N5x N 14.8400 -26.4600 30 C8y C 13.8600 -27.5100 31 C8y C 14.5600 -28.7000 32 S2x S 15.9600 -28.4200 33 C1x C 12.4600 -27.5100 34 C1x C 11.7600 -28.7000 35 N1y N 12.4600 -29.8900 36 C1x C 13.8600 -29.8900 37 C1a C 11.7600 -31.1500BOND 40 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 6 7 1 #Up 8 7 8 2 9 7 9 1 10 9 10 1 11 9 11 1 12 3 12 1 #Down 13 12 13 1 14 13 14 1 15 13 15 2 16 14 16 1 17 14 17 2 18 16 18 1 19 18 19 2 20 19 20 1 21 20 21 2 22 21 22 1 23 22 23 2 24 18 23 1 25 21 24 1 26 2 25 1 #Down 27 25 26 1 28 26 27 1 29 26 28 2 30 27 29 2 31 29 30 1 32 30 31 2 33 31 32 1 34 27 32 1 35 30 33 1 36 33 34 1 37 34 35 1 38 35 36 1 39 31 36 1 40 35 37 1 |
