Bo Qu - TCG GreenChem Inc. | LinkedIn (original) (raw)
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• Highly energetic, inspirational scientific professional with extensive knowledge and…
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TCG GreenChem Inc.
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Publications
Development of Large Scale Asymmetric Process for tert-Butanesulfinamide.
Org. Process Res. Dev. 2019 2019
Enantioselective Synthesis of 4-Methyl-3,4-dihydroisocoumarin via Asymmetric Hydroformylation of Styrene Derivatives
J. Org. Chem. 2019 2019
BABIPhos Family of Biaryl Dihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation
Org. Lett. 2018, 20, 1725. 2018
Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis
ACS Catal. 2018, 8, 10190 2018
Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution
Chem. Sci. 2018, 9, 4505 2018
Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation
J. Org. Chem., 2018, 83, 1448 2018
Enantioselective Arylation of Oxindoles Using Modified BI-DIME Ligands
Synthesis, 2018, 50, 4435 2018
Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights
Org. Lett. 2018, 20, 1333. 2018
Effective BI-DIME Ligand for Suzuki-Miyaura Cross-Coupling Reactions in Water with 500 ppm Palladium Loading and Triton X
Asian J. Org. Chem. 2017, 6, 1285 2017
Enantioselective Nickel-Catalyzed Mizoroki-Heck Cyclizations To Generate Quaternary Stereocenters
Org. Lett. 2017, 19, 3338 2017
General and stereoselective method for the synthesis of sterically congested and structurally diverse P-stereogenic secondary phosphine oxides
Org. Lett. 2017, 19, 1796. 2017
P-Stereogenic Chiral Phosphine-Palladium Complex Catalyzed Enantioselective Synthesis of Phosphoryl-Substituted Atropisomeric Vinylarenes
Adv. Synth. Catal. 2017, 359, 3927. 2017
Ligand Accelerated Stereoretentive Suzuki–Miyaura Coupling of Unprotected 3,3’-Dibromo-BINOL
J. Org. Chem. 2016, 81, 745 2016
Nickel-catalyzed C-3 direct arylation of pyridinium ions for the synthesis of 1-azafluorenes
Chem. Sci. 2016, 7, 5581 2016
Reengineering BI-DIME Ligand Core Based on Computer Modeling to Increase Selectivity in Asymmetric Suzuki-Miyaura Coupling for the Challenging Axially Chiral HIV Integrase Inhibitor`
Adv. Syn. Catal. 2016, 358, 3522 2016
Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor
J. Am. Chem. Soc. 2016, 138, 15473. 2016
Highlighted in Synfacts 2017, 13, 126
Other authors
Synthesis of Enantioenriched 2-Alkyl Piperidine Derivatives through Asymmetric Reduction of Pyridinium Salts
Org. Lett. 2016, 18, 4920 2016
Highlighted in Synfacts 2017, 13, 69.
Synthesis of P-Chiral Dihydrobenzooxaphospholes Through Negishi Cross-Coupling
J. Org. Chem., 2016, 81, 729. 2016
Tunable P-Chiral Bisdihydrobenzooxa- phosphole Ligands for Enantioselective Hydroformylation
Org. Lett. 2016, 18, 3346 2016
Highlighted in Synfacts 2016, 12, 944
Other authors
Aminocarbonylation using electron-rich di-tert-butyl-phosphinoferrocene
Org. synth, 2015, 92, 237 2015
Concise and practical asymmetric synthesis of a challenging atropisomeric HIV integrase inhibitor
Angew. Chem. Int. Ed. 2015, 54, 7144. 2015
Development of a Practical Sequence for Difluoromethylation of 2-Bromopyridines via Copper-Mediated Reductive Coupling and Decarboxylation
Asian J. Org. Chem. 2015, 4, 1262 2015
Development of an Asymmetric Synthesis of a Chiral Quaternary FLAP Inhibitor
J. Org. Chem. 2015, 80, 1651. 2015
Efficient Asymmetric Synthesis of P-Chiral Phosphinamides for New Catalyst Design
Angew. Chem. Int. Ed. 2015, 54, 5474 2015
Efficient asymmetric synthesis of structurally diverse P-stereogenic phosphinamides for catalyst design
Angew. Chem. Int. Ed. 2015, 54, 5474 2015
PAT Application in the Expedited Development of a Three-Step, One-Stage Synthesis of the Dipeptide Intermediate of HCV Protease Inhibitor Faldaprevir Org. Process Res. Dev. 2015, 19, 132.
Org. Process Res. Dev. 2015, 19, 132. 2015
Stereoselective Preparation of Substituted Bicyclic Dihydropyrimidinones
US Appln No. 62/220,434 2015
Angewandte Chemie (International ed. in English) September 15, 2014
An enantioselective copper-catalyzed asymmetric conjugate addition of Me2Zn to (Z)-nitroalkenes led to the formation of all-carbon quaternary stereogenic centers with high stereoselectivity. The key features of the new method are the unprecedented use of [(MeCN)4Cu]PF6 in conjunction with the Hoveyda ligand L1 and the use of (Z)-nitroalkene substrates so that undesired nitroalkene isomerization is minimized and enantioselectivity is enhanced dramatically. We also describe a novel, practical…
An enantioselective copper-catalyzed asymmetric conjugate addition of Me2Zn to (Z)-nitroalkenes led to the formation of all-carbon quaternary stereogenic centers with high stereoselectivity. The key features of the new method are the unprecedented use of [(MeCN)4Cu]PF6 in conjunction with the Hoveyda ligand L1 and the use of (Z)-nitroalkene substrates so that undesired nitroalkene isomerization is minimized and enantioselectivity is enhanced dramatically. We also describe a novel, practical, and highly (Z)-selective nitroalkene synthesis.
See publication
A Highly Concise and Convergent Synthesis of HCV Polymerase Inhibitor Deleobuvir (BI 207127): Application of a One-Pot Borylation−Suzuki Coupling Reaction
Org. Lett. 2014, 16, 4558 2014
A Mild Dihydrobenzooxaphosphazole Oxazoline Ir-P,N Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins
Angew. Chem. Int. Ed. 2014, 53, 14428 2014
Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones
Adv. Synth. Catal. 2014, 356, 301 2014
Development of New P-Chiral P,π-Dihydrobenzooxaphosphole Hybrid Ligands for Asymmetric Catalysis
Org. Lett. 2014, 16, 5494 2014
Facile Entry to an Efficient and Practical Enantioselective Synthesis of a Polycyclic Cholesteryl Ester Transfer Protein Inhibitor
Org. Lett. 2014, 16, 4142 2014
[2,3]-Sigmatropic Rearrangements of 2-Phosphineborane 2-Propen-1-ols: Rapid Access to Enantioenriched Diphosphine Monoxide Derivatives
Org. Lett. 2013, 15, 1136 2013
Asymmetric Methallylation of Ketones Catalyzed by a Highly Active Organocatalyst 3,3’F2-BINOL
Org. Lett. 2013, 15, 1710. 2013
Development of a Safe and Economical Synthesis of Methyl 6-Chloro-5-(trifluoromethyl) nicotinate: Trifluoromethylation on Kilogram Scale
Org. Process Res. Dev. 2013, 17, 940 2013
Efficient Asymmetric Synthesis of P-Chiral Phosphine Oxides via Properly Designed and Activated Benzoxazaphosphinine-2-oxide Agents
J. Am. Chem. Soc. 2013, 135, 2474 2013
Hydrophosphination of Propargylic Alcohols and Amines with Phosphine Boranes
Org. Lett. 2013, 15, 1132 2013
Practical Synthesis of Di-tert-Butyl-Phosphinoferrocene
Org. synth. 2013, 90, 316 2013
Tuning the Peri Effect for Enantioselectivity: Asymmetric Hydrogenation of Unfunctionalized Olefins with the BIPI Ligands
Adv. Synth. Catal. 2013, 355, 1455 2013
Asymmetric Hydrogenation on Hydrazones of Heterocyclic Ketones, Solvent Effect on the Inversion of Configuration
Tetrahedron Lett. 2011, 52, 3718 2011
Oxaphosphole-based Monophosphorus Ligands for Palladium-Catalyzed Amination Reactions
Adv. Catal. Syn. 2011, 353, 533 2011
Novel, Tunable, and Efficient Chiral Bisdihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation Org. Lett. 2010, 12, 176
Org. Lett. 2010, 12, 176 2010
Anionic N-Fries Rearrangement of N-Alkyl-2-iodo Anilides Induced by Iodine-magnesium Exchange: Application for Synthesis of Strained 1,2,3-Trisubstituted Indoles, Org. Lett. 2008, 1
Org. Lett. 2008, 10, 1067 2008
A New Entry to Polycyclic Indole Skeletons via Palladium-Catalyzed Intramolecular Heteroannulation
Org. Lett. 2006, 8, 3573 2006
Mechanism of Acylation of Lithium Phenylacetylide with a Weinreb Amide
J. Org. Chem. 2006, 71, 7117. 2006
Structure of n-Butyllithium in Mixtures of Ethers and Diamines: Influence of Mixed Solvation on 1,2-Additions to Imines
J. Am. Chem. Soc. 2006, 128, 9355 2006
Addition of n-Butyllithium to an Aldimine: Role of Chelation, Aggregation, and Cooperative Solvation
J. Am. Chem. Soc. 2005, 127, 10820 2005
Patents
Preparation of Indenopyridine Derivatives as Intermediates for the Synthesis of 11β-Hydroxysteroid Hydrogenase Type 1 Inhibitors
Issued January 1, 2013 US WO 2013025664, 2013
A Process for the Preparation of Quinoline Derivatives for Use as HIV integrase Inhibitors
Issued January 1, 2012 US WO 2012138670, 2012
Monophosphorus Ligands and Their Use in Cross-coupling Reactions
Issued January 1, 2011 US WO 2011126917, 2011
Novel Chiral Phosphorus Ligands
Issued January 1, 2011 US WO 2011056737, 2011
Process for Preparation of Trifluoromethyl-Substituted Alcohols by Stereoselective Synthesis
Issued January 1, 2010 US WO 2010141331, 2010
A process for the Preparation of Hexahydroindenopyridine Derivatives
US US 20150141651 A1 20150521, 2015
Novel Chiral Nitrogen-phosphorus Ligands and Their Use for Asymmetric Hydrogenation of Alkenes PCT Int. Appl. WO 2015006458 A1 20150115, 2015
US WO 2015006458 A1 20150115, 2015
Novel Ruthenium Catalysts and Their Use for Asymmetric Reduction of Ketones
US US 20150005500 A1 20150101, 2015
Languages
Chinese
Native or bilingual proficiency
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