Firouz Asgarzadeh - OSD Pharmaceutical Solutions LLC | LinkedIn (original) (raw)

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As the Senior Vice President of Pharmaceutics at BioDuro-Sundia, I set the vision…

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Sep 2013

Purpose: New API’s often have a low solubility/dissolution rate and bioavailability. An effective method to increase the dissolution rate is amorphization of crystalline material into a hydrophilic polymer matrix. The purpose of this work is to determine the influence of the composition of EUDRAGIT/ITRACONAZOLE solid dispersions, prepared by spray drying and electrospinning, on the solid state properties and drug dissolution rate
Conclusions: All tested EUDRAGIT® polymers improve the…
Purpose: New API’s often have a low solubility/dissolution rate and bioavailability. An effective method to increase the dissolution rate is amorphization of crystalline material into a hydrophilic polymer matrix. The purpose of this work is to determine the influence of the composition of EUDRAGIT/ITRACONAZOLE solid dispersions, prepared by spray drying and electrospinning, on the solid state properties and drug dissolution rate
Conclusions: All tested EUDRAGIT® polymers improve the dissolution rate of Itraconazole. Spray drying and electrospinning are good techniques for manufacturing amorphous solid dispersions for in vitro dissolution enhancement of Itraconazole

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