Robert D'Annibale - Forge Health | LinkedIn (original) (raw)
About
Former Investment Banker covering Healthcare & Technology sectors. Fluent in financial…
Activity
Experience & Education
Forge Health
View Robert’s full experience
See their title, tenure and more.
Licenses & Certifications
Volunteer Experience
Mentor
StartOut
Mar 2023 - Present1 year 9 months
Mentor LGTBQ+ founders / entrepreneurs.
Dobbs Ferry Downtown Committee
Sep 2022 - Jul 2024 1 year 11 months
Corporate Champion
STEPtember now
Sep 2021 - Present3 years 3 months
Raised funds and awareness regarding research for cerebral palsy.
Publications
The Journal of the Federation of American Societies for Experimental Biology April 25, 2011
At the ends of chromosomes are segments of DNA called telomeres, which permit cells to replicate, protect DNA, and repair DNA. Multistranded and alternative DNA structures play important roles in gene expression. Novel alternative, multistranded, and helical transitional nucleic acid microarrays have been constructed, viz., Z-DNA, triplex DNA and quadruplex DNA. These microarrays allow for characterization of the structure and function of Z-DNA, triplex DNA and quadruplex DNA under different…
At the ends of chromosomes are segments of DNA called telomeres, which permit cells to replicate, protect DNA, and repair DNA. Multistranded and alternative DNA structures play important roles in gene expression. Novel alternative, multistranded, and helical transitional nucleic acid microarrays have been constructed, viz., Z-DNA, triplex DNA and quadruplex DNA. These microarrays allow for characterization of the structure and function of Z-DNA, triplex DNA and quadruplex DNA under different conditions. They allow for identification of drugs that bind to multistranded nucleic acids and for characterization of genomic elements that contain triplex DNA and telomeres. The novel microarrays will allow for a new approach towards studying gene expression and drug discovery. The new microarrays go beyond the limitations of conventional DNA microarrays, which focus on the primary structure of nucleic acids (i.e., base pairs) and ignore DNA secondary structure. These microarrays can be used for aging, cancer and infectious disease (e.g., tuberculosis, malaria and AIDS) research. The microarrays can also be employed for enhancing or inhibiting of gene expression. With these next generation DNA microarrays, scientists will have access to all of the uncharted structures that control gene expression, and aid in developing new classes of drugs for disease. Supported by a 2010 NYIT ISRC grant.
See publication
Biophysical Journal - BIOPHYS J , vol. 100, no. 3, pp. 78a-78a, 2011 2011
Millions die every year from infectious diseases such as tuberculosis, malaria and AIDS. More research needs to be performed to find new target sites (exotic DNA) for treatments of these pathologies. The majority of DNA is right-handed double-stranded (ds-) B-DNA. However, other forms of nucleic acids exist, viz., ds-Z-DNA, triple-stranded DNA and four-stranded DNA. Our group has developed novel ds-DNA microarrays that contain tuberculosis genes (Mycobacterium tuberculosis) and malaria genes…
Millions die every year from infectious diseases such as tuberculosis, malaria and AIDS. More research needs to be performed to find new target sites (exotic DNA) for treatments of these pathologies. The majority of DNA is right-handed double-stranded (ds-) B-DNA. However, other forms of nucleic acids exist, viz., ds-Z-DNA, triple-stranded DNA and four-stranded DNA. Our group has developed novel ds-DNA microarrays that contain tuberculosis genes (Mycobacterium tuberculosis) and malaria genes [i.e., Plasmodium falciparum (var, rif and stevor genes)]. Employing the novel microarrays allows for the entire genes or segments to be immobilized as intact, unaltered, nondenatured DNA molecules. These microarrays allow for the discovery of drugs that bind to the immobilized intact genes under different environmental conditions (with or without proteins, supercoiling, ionic conditions, drugs). They also allow characterization of DNA structure and function. Using the new microarrays and bioinformatics, genes can be characterized for the presence of B-DNA and Z-DNA (transcription studies). Genes that contain DNA with the potential for B-DNA to Z-DNA transitions can be studied under specific environmental conditions. These infectious disease-based microarrays will include ds-Z-DNA, ds-B-DNA, B-DNA/Z-DNA junctions, mitochondrial DNA, and helical transitional arrays (B-DNA to Z-DNA). These new microarrays will allow for unprecedented drug discovery and gene expression studies. They will go beyond the limitations of commercially available, conventional ss-DNA microarrays (hybridization), which only focus on DNA primary structure (base pairs) and ignore DNA secondary structure. With these new microarrays, researchers will have access to all of the previously unexplored DNA structures that regulate gene expression.
Other authors
Recommendations received
More activity by Robert
Other similar profiles
Explore collaborative articles
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
Others named Robert D'Annibale
1 other named Robert D'Annibale is on LinkedIn
See others named Robert D'Annibale