Mingyang Xu - 耶鲁大学 | LinkedIn (original) (raw)
About
Hi! My name is Mingyang Xu, majoring at Chemical and Biological engineering at Cornell…
Activity
Experience & Education
耶鲁大学
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Publications
Patents
Oxidized ascorbic acid-modified paclitaxel-targeted nanomicelles
Filed June 28, 2019 CN 201910573130.7
Paclitaxel (PTX) is an organic compound extracted from natural Chinese yew (Taxuschinensis) with good effect in fighting against cancer. However, PTX has a low solubility in water. The solubilizerCremophorEL employed in its clinical preparations Taxol®has strong toxic side effects that affect clinical therapeutic effect. Abraxane®is expensive in the market.
The current study designs DHA-PEG-PLGAconjugate. With PTX as delivery model drug, the current study prepares PTX/DHA nanomicelles. 1H…
Paclitaxel (PTX) is an organic compound extracted from natural Chinese yew (Taxuschinensis) with good effect in fighting against cancer. However, PTX has a low solubility in water. The solubilizerCremophorEL employed in its clinical preparations Taxol®has strong toxic side effects that affect clinical therapeutic effect. Abraxane®is expensive in the market.
The current study designs DHA-PEG-PLGAconjugate. With PTX as delivery model drug, the current study prepares PTX/DHA nanomicelles. 1H NMRis utilized to characterize the structure of the DHA-PEG-PLGA conjugate. Theparticle diameter and morphology of the nanomicellesare is characterized by DLS. CCK-8 method is employed to assess the cytotoxicity of target and non-target PTX micelles to MDA MB 231, which effects are verified by tumor bearing nude mouse.
The findings show that DHA modified target micelles have goodtargetabilityand safety. Targeting micelles show their in-vitro anti-tumor activity superior to that of Taxol®with extension of administration time. Meanwhile, the drug cost is lower than that of Abraxane®.
Courses
Advanced Studies in Linear Algebra and Multivariable Calculus BHSF
Honor Seminar
Advanced Studies in Literature BHSF
Honor Seminar
Projects
Wildlife Crime in China
Apr 2020 - Present
More Than Food Consumption: Delineating Wildlife Utilization Industry in China
Although the origin of the COVID-19 virus has not been confirmed, many believe that it is linked to a wildlife market in Wuhan. In the wake of the epidemic, China issued a provisional national ban on eating wild animals to prevent further threats to public health. However, the focus on food consumption alone can obscure the complexity of China’s wildlife industry. In order to offer a comprehensive description…
More Than Food Consumption: Delineating Wildlife Utilization Industry in China
Although the origin of the COVID-19 virus has not been confirmed, many believe that it is linked to a wildlife market in Wuhan. In the wake of the epidemic, China issued a provisional national ban on eating wild animals to prevent further threats to public health. However, the focus on food consumption alone can obscure the complexity of China’s wildlife industry. In order to offer a comprehensive description of both the legal and illegal wildlife trade in China, we reviewed relevant Chinese policy documents and characterized five key sectors of the industry, including those for food, traditional medicine, arts & crafts, display & performance, and pet markets. We also analyzed 704 court verdicts of prosecutions related to the crime of “illegally purchasing, transporting, and selling precious, endangered wildlife and their products” in 2019. Results reveal hotspots of illicit wildlife trade, profiles of those people involved, and the common platforms and channels used for illegal transaction. Elephants, pangolins, macaques, geckoes, and pheasants are among those species whose bodies or derivatives are found to be illegally traded, albeit for different sectors of the wildlife industry. The co-presence of multiple species in most cases shows the limitation of single-species conservation approaches. To effectively safeguard the health of both people and wildlife, we argue for a systematic strategy to tackle illegal wildlife trade through better legislation, enforcement and public education. In particular, we emphasize the need for enlarging public participation in decision-making processes to reconcile the conflict between wildlife utilization and conservation.
Jun 2019 - Present
•Founder of China HOSA and helped organize regional and national competitions.
•Adviser of the national China HOSA student club.
•Founded HOSA_China Organization and launched 1 international, 3 national, and 5 regional events.
•Strategized school club development methods and helped to establish 43 student clubs in 15 different cities.
•Awarded the Best Organization and the Most Develop Organization in the international HOSA 2020 Festival.
See project
Mar 2019 - Oct 2019
Genetically engineered bacteria in science and industry bears the risk of intended stolen and unintended release to the environment. Such releases may interfere with the balanced microbial ecosystems before and even destroy the original ecological balance. To solve this problem, our team designed a digitalizing bistable module that can detect and prevent the stealing or release of engineering bacteria form labs or factories.We utilize the mutual bistable system that enable conditional…
Genetically engineered bacteria in science and industry bears the risk of intended stolen and unintended release to the environment. Such releases may interfere with the balanced microbial ecosystems before and even destroy the original ecological balance. To solve this problem, our team designed a digitalizing bistable module that can detect and prevent the stealing or release of engineering bacteria form labs or factories.We utilize the mutual bistable system that enable conditional suicide of engineered bacteria. To better function, we use a sensor to sense the change of external environment, a recombinase as a flip to form memory which could record the action of stealing or release, and DNase/toxic protein to decompose the functioning bacteria.
See project
Honors & Awards
Sustainable and Development Goal Award
iGEM_APAC_ventureship
May 2020
Starting up company 水 Shui
National Gold Prize winner of the USA Biolympiad
ASDAN_China
Semi-finals team in Beijing Division
National High School Debate League of China
Apr 2019
The Second Place Winner of "Marketing" of National FBLA competition
FBLA_China
May 2018
the best team performance on the fourth China-and-Russia culture festival
Organizer of the Sino-Russian Cultural Festival
Aug 2017
Merit Student; Excellent Student Council; Dean’s List
Beijing No.4 High School
Languages
中文
Native or bilingual proficiency
English
Full professional proficiency
Organizations
The Cornell Lab of Ornithology
member
Mar 2020 - Present
As a unit of Cornell’s College of Agriculture and Life Sciences, we bring together world-class science and teaching with the agility and real-world impact of a nonprofit organization. Our work spans disciplines from science to art, engineering to education. Our global community includes you and other supporters, participants, and partners from all walks of life, united by a love for birds and nature and a commitment to help protect our planet.
HOSA_China
Secondary Representative
Aug 2019 - Present
China Conservation Support
Teaching Assistant
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Another publication from my dissertation fieldwork just came out. Researchers investigating human attitudes toward wildlife often evaluate how…
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Thanks to Amber Dance from Nature for this great feature on rare earth biomining featuring my lab and Alexa Schmitz and REEgen. Thanks to ARPA-E…
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A very successful Day 1, for both Bluepha and Helian. Today will be even better, I have a feeling about this. Onwards and upwards! 🙌
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It's good to be home for the holidays .. 🌲❄ 1.3 years & 65 flights later, I couldn't be more excited to share that I'm taking an offer to move to…
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Looking forward to participating in the 20th anniversary iGEM Jamboree in Paris this week. Nordic BioVentures will be hosting a workshop on…
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