Zhijun Bai , Ph.D. - Terumo Neuro | LinkedIn (original) (raw)
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Medical Device Development Leader with 20+ Year’s Successful Track Record
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Terumo Neuro
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Publications
Enhancing resistance to pitting corrosion in mechanically polished stainless steel 316 LVM by water treatment
Electrochemistry Communications 15 (2012) 54–58 2012
We present an extremely simple and environmentally friendly technique that appears to dramatically reduce pitting corrosion on stainless steel 316LVM.
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The intrinsically high pitting corrosion resistance of mechanically polished nitinol in simulated physiological solutions
J Biomed Mater Res Part B: Appl Biomater 99B: 1–13, 2011. 2011
Nitinol wires have been widely used in many biomedical applications, such as cardiovascular stent due to their superelasticity and shape memory effect. However, their corrosion properties and the related biocompatibility are not well understood, and the reported results are controversial. In this study, we evaluate the pitting corrosion property of nitinol, titanium,nickel, and 316L stainless steel (316LSS) wires with different surface roughnesses in a saline solution at 37C.
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Surface characteristics and protein adsorption on combinatorial binary Ti-M (Cr, Al, Ni) and Al-M (Ta, Zr) library films
J Biomed Mater Res 92A: 521–532, 2010 2010
Systematic studies of protein adsorption onto metallic biomaterial surfaces are generally lacking. Here, combinatorial binary library films with compositional gradients of Ti1-xCrx, Ti1-xAlx, Ti1-xNix and Al1-xTax, (0 < x < 1) and Al1-yZry (0 < y < 0.5) as well as corresponding pure metal films were sputtered onto clean Si surfaces.
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Fibrinogen adsorption onto 316L stainless steel, Nitinol and titanium
Surface Science 603 (2009) 839–846 2009
Fibrinogen adsorption onto mechanically polished biomedical grade 316L stainless steel (316LSS), nickel titanium alloy (Nitinol) and commercially pure titanium (CpTi) surfaces were studied by measurements of adsorption isotherms and adsorption kinetics using an ex-situ wavelength dispersive spectroscopy technique (WDS).
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A high throughput method using electron microprobe analysis for quantification of protein adsorption on surfaces
Surface Science 602 (2008) 795–804 2008
Protein adsorption on solid surfaces can be easily and accurately quantified by electron microprobe analysis using wavelength dispersive spectroscopy (WDS) to detect the carbon and nitrogen atoms within the protein.
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ASM Handbook, Volume 13C: Corrosion: Environments and Industries (P837-852) 2006
BIOMATERIALS used in medical devices and prostheses are implanted into the human body to replace, repair, or restore the function of tissue. The term biomaterial includes synthetic materials such as metals (alloys), polymers, and ceramics as well as some natural materials including bioceramics (e.g., hydroxyapatite) and biopolymers (e.g., collagen). Metallic biomaterials represent the most highly used class of biomaterials and generally have advantages over other biomaterials in terms of…
BIOMATERIALS used in medical devices and prostheses are implanted into the human body to replace, repair, or restore the function of tissue. The term biomaterial includes synthetic materials such as metals (alloys), polymers, and ceramics as well as some natural materials including bioceramics (e.g., hydroxyapatite) and biopolymers (e.g., collagen). Metallic biomaterials represent the most highly used class of biomaterials and generally have advantages over other biomaterials in terms of mechanical properties, such as high tensile strength, high fatigue strength, and good processability. Biomedical devices are usually subjected to static or dynamic forces, such as in orthopedic and cardiovascular applications. On the other hand, some electrode materials, such as pacemaker leads, are made of metals such as cobalt-base alloy (MP35N) or platinum alloy (Pt-Ir) because of their good electrical conductivity and because they are not as highly stressed. The main metallic biomaterials in use today can be categorized into three groups: iron-base alloys (stainless steels), cobalt-base alloys, and titanium-base alloys. While other metals and alloys are used, this article focuses only on the corrosion behavior of these three groups. These alloys all form a thin, compact, semiconducting oxide (or hydroxide) film (usually called a passive film) that protects the substrate alloy from corrosive environments as well as interacts with the host during the host response. To understand corrosion requires an understanding of these oxides.
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Quantification of the kinetics and thermodynamics of protein adsorption using atomic force microscopy
J Biomed Mater Res 72A: 246–257, 2005 2005
Both in situ and ex situ methods for quantifying area fraction coverage of protein on a surface using atomic force microscopy were developed.
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Patents
Method for preparing biomedical surfaces
Issued January 1, 2012 US 8012338
A method for selectively dissolving the beta (β) phase of a titanium alloy out of the surface of the alloy, thereby leaving behind a nano-scale porous surface having enhanced bonding properties with either a biological tissue, such as bone, or an adhesive material, such as a polymer or ceramic by immersing the alloy in an ionic aqueous solution containing high levels of hydrogen peroxide and then exposing the alloy to an electrochemical voltage process resulting in the selective dissolution of…
A method for selectively dissolving the beta (β) phase of a titanium alloy out of the surface of the alloy, thereby leaving behind a nano-scale porous surface having enhanced bonding properties with either a biological tissue, such as bone, or an adhesive material, such as a polymer or ceramic by immersing the alloy in an ionic aqueous solution containing high levels of hydrogen peroxide and then exposing the alloy to an electrochemical voltage process resulting in the selective dissolution of the beta phase to form a nano-topographic metallic surface.
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Languages
English
Full professional proficiency
Chinese
Native or bilingual proficiency
More activity by Zhijun
Very excited to have another education paper published (acceptance rate of 16%)! Zhu, B., Parsley, K. M., Griscom, H. P., Wallace, L. E.…
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