clomiphene (Clomid): Fertility Drug Side Effects & Dosage (original) (raw)

• What is clomiphene, and how does it work (mechanism of action)?
• What are the side effects of clomiphene?
• What is the dosage for clomiphene?
• Which drugs or supplements interact with clomiphene?
• Is clomiphene safe to take if I'm pregnant or breastfeeding?
• What else should I know about clomiphene?

What is clomiphene, and how does it work (mechanism of action)?

Clomiphene is an oral medication used for stimulating ovulation. It binds to estrogen receptors in the hypothalamus, pituitary gland, ovary, endometrium, vagina, and cervix. It causes production of hormones (gonadotropins) by the pituitary which stimulates ovulation. The FDA approved clomiphene in February 1967.

What brand names are available for clomiphene?

Serophene

Is clomiphene available as a generic drug?

Yes

Do I need a prescription for clomiphene?

Yes

What are the side effects of clomiphene?

The most common side effects of clomiphene are:

• ovarian enlargement,
• flushing,
• stomach discomfort,
• breast discomfort,
• blurred vision,
• nausea, and
• vomiting.

Other important side effects include

• abnormal heart beats,
• acne,
• allergic reactions,
• headaches,
• uterine bleeding,
• back pain, and
• muscle pain.

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What is the dosage for clomiphene?

The recommended dose is 50 to 100 mg orally for 5 days. The initial dose is 50 mg which may be increased to 100 mg if there is no response. Dosage may be repeated as early as 30 days after the previous treatment.

Which drugs or supplements interact with clomiphene?

No drug interactions are listed in the prescribing information.

Is clomiphene safe to take if I'm pregnant or breastfeeding?

Clomiphene should not be taken by pregnant women since it does not offer any benefit to pregnant women.

It is not known whether clomiphene is excreted intobreast milk. It may reduce lactation in some women.

What else should I know about clomiphene?

What preparations of clomiphene are available?

Tablets: 50 mg

How should I keep clomiphene stored?

Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

Health News

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

References

FDA Prescribing Information