Meningococcal ABCWY Pentavalent Vaccine: Side Effects, Dosage (original) (raw)
Generic Name: meningococcal ABCWY pentavalent vaccine
Brand Name: Penbraya
Drug Class: Vaccines, Inactivated, Bacterial
What is the meningococcal ABCWY pentavalent vaccine, and what is it used for?
Meningococcal ABCWY pentavalent vaccine is administered to protect a person from meningococcal disease caused by the bacteria Neisseria meningitidis serogroups A, B, C, W, and Y. Meningococcal disease is a severe, and sometimes, life-threatening bacterial infection of the lining of the brain, spinal canal, and the bloodstream. There are at least 13 strains of N. Meningitidis, but serogroups A, B, C, W, X and Y account for a majority of invasive disease and among these, B, C and Y are the most prevalent in the United States.
Meningococcal disease can affect anyone, even healthy individuals, and turn fatal within 24 hours. It is, however, more common in children younger than 1 year old, young adolescents and adults 16-23 years old, and adults above 65 years and older. Meningococcal ABCWY pentavalent vaccine is administered as two intramuscular injections 6 months apart in individuals of age 10 to 25 years.
N. meningitidis lives in the nose and throat of approximately 10% of the population without causing disease. N. meningitidis is transmitted through saliva and nasal droplets of a carrier and can cause invasive disease in others who are vulnerable due to age, medical conditions, compromised immunity or other factors. The bacteria get into the bloodstream, cross the blood-brain barrier and infect the membranes of the brain and spinal cord.
Meningococcal ABCWY pentavalent vaccine is an inactivated bacterial vaccine prepared from protein and carbohydrate fragments of A, B, C, W and Y strains of N. meningitidis grown in culture, purified and killed (inactivated) to prevent them from causing disease. Meningococcal ABCWY pentavalent vaccine stimulates the immune system to produce antibodies that recognize the N. meningitidis bacterial molecules (antigens), and attack and kill them, protecting the vaccinated individual from severe disease if exposed to the bacteria in the future.
Meningococcal ABCWY pentavalent vaccine is conjugated with a tetanus bacterial toxoid used as a carrier protein and to enhance immune response. Toxoids are toxins that are chemically altered to eliminate the toxicity, but can be recognized as bacterial antigens by the immune system. The vaccine does not contain any preservatives.
Warnings
- Do not administer meningococcal ABCWY pentavalent vaccine to anyone with a history of severe allergic reactions (anaphylaxis) to any component of the formulation.
- Administer meningococcal ABCWY pentavalent vaccine only as an intramuscular injection. Do not use any other route to administer.
- Meningococcal ABCWY pentavalent vaccine should be administered only in a clinical setting where medical facilities and trained personnel are readily available to manage severe reactions, should they occur.
- Injectable vaccines, including meningococcal ABCWY pentavalent vaccine, can cause fainting. Precautions should be taken when administering the vaccine to prevent falling and injury.
- Individuals with altered immunocompetence may have reduced immune response to the meningococcal ABCWY pentavalent vaccine.
- There is an increased risk of developing invasive disease from N. meningitidis serogroups A, B, C, W, and Y, despite development of antibodies in individuals:
- With certain deficiencies in the complement system, a part of the immune system that enhances the ability of antibodies to kill pathogens.
- Taking treatment that inhibits terminal complement system activation.
- Vaccination with meningococcal ABCWY pentavalent vaccine may not protect 100% of recipients from invasive disease.
- Meningococcal ABCWY pentavalent vaccine cannot prevent tetanus, and cannot substitute for a tetanus vaccination.
- There have been unexpected reports of Guillain-Barré syndrome (GBS), a rare disorder in which the immune system attacks the peripheral nerves, with the use of another meningococcal vaccine. Consider benefits and risks before administering meningococcal ABCWY pentavalent vaccine to individuals with a history of GBS.
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What are the side effects of meningococcal ABCWY pentavalent vaccine?
Common side effects of meningococcal ABCWY pentavalent vaccine include:
- Injections site reactions including:
- Pain
- Redness (erythema)
- Swelling
- Fatigue
- Headache
- Muscle pain
- Joint pain
- Chills
- Fever
- Vomiting
- Diarrhea
Less common side effects of meningococcal ABCWY pentavalent vaccine include:
- Allergic reactions
- Severe allergic reactions (anaphylaxis)
- Fainting (syncope)
Call your doctor immediately if you experience any of the following symptoms or serious side *effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
Health News
What are the dosages of meningococcal ABCWY pentavalent vaccine?
Lyophilized powder for reconstitution
- 0.5 mL suspension for intramuscular (IM) injection after reconstitution
- Supplied as kit that includes lyophilized MenACWY component, a prefilled syringe containing the MenB component, and a vial adapter
Adult and Pediatric:
Meningococcal Vaccination
- Indicated for active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, B, C, Y, and W-135 in persons aged 10-25 years
- 2 dose series: 0.5 mL IM administered 6 months apart
Overdose
There are no reports of overdose with meningococcal ABCWY pentavalent vaccine. Overdose is unlikely to occur because the vaccine comes with the recommended doses in a kit and is administered in a clinical setting.
What drugs interact with meningococcal ABCWY pentavalent vaccine?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
Meningococcal ABCWY pentavalent vaccine has no listed severe, serious, moderate, or mild interactions with other drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
- No developmental toxicity studies have been performed with the use of meningococcal ABCWY pentavalent vaccine during pregnancy. There are no clinical studies on the use of the vaccine in pregnant women to determine a vaccine-associated risk to the fetus.
- There are no data on the presence of meningococcal ABCWY pentavalent vaccine in breastmilk, or its effect on milk production or the breastfed infant.
- Decision to breastfeed should be made after considering the developmental and health benefits of breastfeeding, along with the potential adverse effects to the infant from the vaccine or the mother’s susceptibility to contracting the disease that the vaccine prevents.
- There is a pregnancy exposure registry that monitors pregnancy outcomes in individuals exposed to meningococcal ABCWY pentavalent vaccine during pregnancy. Individuals who received the vaccine during pregnancy are encouraged to contact, or have their healthcare provider contact, 1-877-390-2953 to enroll in or obtain information about the registry.
Summary
Meningococcal ABCWY pentavalent vaccine is administered to protect a person from meningococcal disease caused by the bacteria Neisseria meningitidis serogroups A, B, C, W, and Y. Common side effects of meningococcal ABCWY pentavalent vaccine include injections site reactions, fatigue, headache, muscle pain, joint pain, chills, fever, vomiting, and diarrhea.
Related Disease Conditions
-
Meningitis Meningitis is inflammation of the membranes that cover the spinal cord and brain. Symptoms include fever, headache, and a stiff neck. Treatment of meningitis depends upon the cause of the infection and may include antibiotics or antiviral medications. -
What Are the Side Effects of the Pneumonia Vaccine? The pneumonia vaccine can help protect against pneumococcal infections. Learn what the pneumonia vaccine is all about, and what to do if you experience side effects. Pneumonia is an infection in your lungs that is usually caused by bacteria, viruses or fungi. -
Pneumonia Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection. -
Is Pneumonia Contagious? Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. If inflammation affects both lungs, the infection is termed double pneumonia. If it affects one lung, it is termed single pneumonia. If it affects only a certain lobe of a lung it's termed lobar pneumonia. Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue. -
Is Meningitis Contagious? Meningitis, inflammation of the meninges, symptoms and signs include neck stiffness, headache, and fever. There are five types of meningitis: viral, bacterial, fungal, parasitic, and noninfectious. -
How Long Is Pneumonia Contagious? Pneumonia may be contagious for 2-14 days. Usually, the goal of medications given for pneumonia is to limit the spread of the disease. -
How Quickly Does Meningitis Progress? Meningitis is an infection of the meninges or coverings of the brain. This serious illness can progress very quickly and have lifelong consequences. So, it is important to get medical attention as soon as possible. The most frequent cause of meningitis is a viral or bacterial infection. Rarely, a fungus can cause it. -
How Long Does the Meningitis Vaccine Last? Learn how the meningitis vaccine works and how long it is effective. -
Bronchitis vs. Pneumonia Bronchitis and pneumonia both affect breathing and cause coughing, but there are key differences between causes, symptoms, and treatment. -
Meningococcal Disease (Meningococcemia) Meningococcal disease (meningococcemia) is a bloodstream infection caused by Neisseria meningitides. Meningococcemia symptoms include fever, headache, fatigue, and body aches. Meningococcemia is treated with intravenous antibiotics. There is an effective and safe vaccine to protect against most serogroups of meningococcus that cause meningococcemia. -
How Serious Is Pneumococcal Pneumonia? Pneumococcal pneumonia is a serious and potentially lethal lung disease that kills around 1 in every 20 people. Check out the center below for more medical references on pneumonia, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness. -
How Often Do You Need to Get the Meningitis Vaccine? Meningitis is a disease that's defined by inflammation in membranes — called meninges — near your brain and spinal cord. Data is limited, but current research suggests that the MenACWY vaccine becomes unreliable for protection after five years and the MenB vaccine after only one or two years. - What Are the 3 Types of Meningitis? Meningitis is a serious condition that needs medical attention. Learn about the 3 types of meningitis, what causes meningitis, how doctors diagnose meningitis, and how meningitis is treated.
- Can Pneumonia Go Away On Its Own? Mild pneumonia may be healed by body’s defense system. However severe cases of pneumonia require medical attention especially viral pneumonia.
-
Which Is More Serious: Encephalitis or Meningitis? What is the difference between encephalitis and meningitis? -
What are the Three Major Causes of Pneumonia? Pneumonia is a lung infection that affects many people. Learn the signs of pneumonia, what causes it, how doctors diagnose it, and what you can do to treat it. -
How Do You Get Bacterial Meningitis? Bacterial meningitis is an infection of the tissue surrounding the brain and spinal cord. Learn more about the signs of bacterial meningitis, what causes bacterial meningitis, when to see a doctor, and how to treat bacterial meningitis. - How Do You Know if You Have Meningitis? Meningitis is a potentially life-threatening inflammation of the layers of tissue and fluid that cover the spine and brain. Learn the signs of meningitis, what causes it, how doctors diagnose it, and what you can do to treat it.
Treatment & Diagnosis
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Medically Reviewed on 2/8/2024
References
https://www.rxlist.com/penbraya-drug.htm
https://reference.medscape.com/drug/penbraya-meningococcal-abcwy-pentavalent-vaccine-4000361
https://www.fda.gov/media/173223/download?attachment