Epstein-Barr Virus and Kaposi's Sarcoma Herpesvirus/Human Herpesvirus 8 (original) (raw)

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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 70

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©International Agency for Research on Cancer, 1997.

This volume of the IARC Monographs presents the results of an expert evaluation of the carcinogenic risk to humans posed by infection with two lymphotropic herpesviruses: Epstein-Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8, a new human herpesvirus detected in 1994 in Kaposi's sarcoma associated with AIDS. The viruses are evaluated in separate monographs, which consider the biology of the virus, the epidemiology of infections, related animal viruses, and mechanistic studies, in addition to abundant studies of cancer in humans.

Contents

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• NOTE TO THE READER

• LIST OF PARTICIPANTS

• PREAMBLE

• GENERAL REMARKS

• INTRODUCTION

• THE MONOGRAPHS

  • Epstein-Barr virus
    * 1. Virus–Host Interactions
    * 2. Studies of Cancer in Humans
    * 3. Studies of Cancer in Animals
    * 4. Other Data Relevant to an Evaluation of Carcinogenicity and Its Mechanisms
    * 5. Summary of Data Reported and Evaluation
    * 6. References
  • Kaposi's sarcoma herpesvirus/human herpesvirus 8
    * 1. Virus–Host Interactions
    * 2. Studies of Cancer in Humans
    * 3. Studies of Cancer in Animal Models
    * 4. Other Data Relevant to an Evaluation of Carcinogenesis and its Mechanisms
    * 5. Summary of Data Reported and Evaluation
    * 6. References

• ABBREVIATIONS

• SUPPLEMENTARY CORRIGENDA TO VOLUMES 1–69

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LIBRARY CATALOGUING DATA

This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 17–24 June 1997

Lyon, France - 1997

IARC MONOGRAPHS

In 1969, the International Agency for Research on Cancer (IARC) initiated a programme on the evaluation of the carcinogenic risk of chemicals to humans involving the production of critically evaluated monographs on individual chemicals. The programme was subsequently expanded to include evaluations of carcinogenic risks associated with exposures to complex mixtures, life-style factors and biological agents, as well as those in specific occupations.

The objective of the programme is to elaborate and publish in the form of monographs critical reviews of data on carcinogenicity for agents to which humans are known to be exposed and on specific exposure situations; to evaluate these data in terms of human risk with the help of international working groups of experts in chemical carcinogenesis and related fields; and to indicate where additional research efforts are needed.

This project is supported by PHS Grant No. 5-U01 CA33193-16 awarded by the United States National Cancer Institute, Department of Health and Human Services. Additional support has been provided since 1986 by the European Commission.

• ©International Agency for Research on Cancer, 1997

IARC Library Cataloguing in Publication Data

Epstein-Barr virus and Kaposi's sarcoma herpesvirus/human herpesvirus 8 /

• IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1997 : Lyon, France).
• (IARC monographs on the evaluation of carcinogenic risks to humans; 70)
• 1. Epstein-Barr virus – congresses 2. Kaposi's sarcoma herpesvirus / human herpesvirus 8 – congresses I. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans II. Series
• ISBN 92 832 1270 3 (NLM Classification: W 1)
• ISSN 0250-9555
• Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention.
• All rights reserved. Application for rights of reproduction or translation, in part or in toto, should be made to the International Agency for Research on Cancer.
• Distributed by IARC_Press_ (Fax: +33 47273 8: 02; E-mail: rf.crai@sserp) and by the World Health Organization Distribution and Sales, CH-1211 Geneva 27 (Fax: +41 22791 4857)
• PRINTED IN FRANCE

©International Agency for Research on Cancer, 1997.

Bookshelf ID: NBK385507