Tshr thyroid stimulating hormone receptor [Mus musculus (house mouse)] - Gene (original) (raw)

S I D E B A R

Official Symbol

Tshrprovided by MGI

Official Full Name

thyroid stimulating hormone receptorprovided by MGI

Primary source

MGI:MGI:98849

See related

Ensembl:ENSMUSG00000020963 AllianceGenome:MGI:98849

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Mus musculus

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus

Also known as

hyt; pet; hypothroid

Summary

Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including adult locomotory behavior; dopaminergic neuron differentiation; and inner ear development. Located in plasma membrane. Is expressed in endocrine gland and urinary system. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); cardiomyopathy; hyperthyroidism (multiple); and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]

Expression

Biased expression in subcutaneous fat pad adult (RPKM 19.7), genital fat pad adult (RPKM 11.8) and 3 other tissues See more

Orthologs

human all

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Location:

12 D3; 12 44.51 cM

Exon count:

11

Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (91367767..91507283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (91400993..91540509)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes

  1. Excess TSH causes abnormal skeletal development in young mice with hypothyroidism via suppressive effects on the growth plate. Endo T, et al. Am J Physiol Endocrinol Metab, 2013 Sep 1. PMID 23880310
  2. Thyroid-stimulating hormone stimulation downregulates autophagy and promotes apoptosis in chondrocytes. Xin W, et al. Endocr J, 2017 Jul 28. PMID 28626114
  3. Characteristics of infertility in female hypothyroid (hyt) mice. Jiang JY, et al. Reproduction, 2001 Nov. PMID 11690529
  4. Comparative Assessment of Female Mouse Model of Graves' Orbitopathy Under Different Environments, Accompanied by Proinflammatory Cytokine and T-Cell Responses to Thyrotropin Hormone Receptor Antigen. Berchner-Pfannschmidt U, et al. Endocrinology, 2016 Apr. PMID 26872090
  5. Identification of a point mutation in the thyrotropin receptor of the hyt/hyt hypothyroid mouse. Stein SA, et al. Mol Endocrinol, 1994 Feb. PMID 8170469

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

  1. Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model.
    Title: Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model.
  2. TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction.
    Title: TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction.
  3. Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice.
    Title: Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice.
  4. Presence of TSHR in NK Cells and Action of TSH on NK Cells.
    Title: Presence of TSHR in NK Cells and Action of TSH on NK Cells.
  5. Long Term Rescue of the TSH Receptor Knock-Out Mouse - Thyroid Stem Cell Transplantation Restores Thyroid Function.
    Title: Long Term Rescue of the TSH Receptor Knock-Out Mouse - Thyroid Stem Cell Transplantation Restores Thyroid Function.
  6. Adipose-specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes.
    Title: Adipose-specific inactivation of thyroid stimulating hormone receptors in mice modifies body weight, temperature and gene expression in adipocytes.
  7. The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice.
    Title: The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice.
  8. A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.
    Title: A Mouse Thyrotropin Receptor A-Subunit Transgene Expressed in Thyroiditis-Prone Mice May Provide Insight into Why Graves' Disease Only Occurs in Humans.
  9. Expression of TSHR and of CART is suppressed in response to lipopolysaccharides within the arcuate nucleus in the hypothalamus of the mouse. The present findings highlight hypothalamic TSH receptor mechanisms and CART as putative adaptive neuroendocrine components in the response to acute inflammation. Findings suggest that central and peripheral CART is affected by acute inflammation.
    Title: LPS immune challenge reduces arcuate nucleus TSHR and CART mRNA and elevates plasma CART peptides.
  10. analysis of TSHR expression in mouse pancreatic beta cells
    Title: The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice.

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Markers

Preferred Names

thyrotropin receptor

Names

TSH-R

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in [Genomic regions, transcripts, and products](#geneGenomic regions, transcripts, and products) above.

mRNA and Protein(s)

  1. NM_001113404.1 → NP_001106875.1 thyrotropin receptor isoform 2 precursor
    See identical proteins and their annotated locations for NP_001106875.1
    Status: VALIDATED
    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    [AK041086, BB645263](/nuccore/AK041086, BB645263)
    Consensus CDS
    CCDS49135.1
    UniProtKB/TrEMBL
    Q78U67
    Related
    ENSMUSP00000021343.7, ENSMUST00000021343.8
    Conserved Domains (2) summary
    sd00033
    Location:55 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13306
    Location:65 → 221
    LRR_5; Leucine rich repeats (6 copies)
  2. NM_011648.5 → NP_035778.3 thyrotropin receptor isoform 1 precursor
    See identical proteins and their annotated locations for NP_035778.3
    Status: VALIDATED
    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    [BB645263, BC086691](/nuccore/BB645263, BC086691)
    Consensus CDS
    CCDS26088.1
    UniProtKB/Swiss-Prot
    P47750, Q562E4, Q9D697
    Related
    ENSMUSP00000021346.8, ENSMUST00000021346.14
    Conserved Domains (4) summary
    pfam00001
    Location:437 → 678
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:76 → 138
    LRR_8; Leucine rich repeat
    cl21587
    Location:417 → 527
    7tm_2; 7 transmembrane receptor (Secretin family)
    sd00033
    Location:54 → 77
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J
    Range
    91367767..91507283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)