FHL1 four and a half LIM domains 1 [Homo sapiens (human)] - Gene (original) (raw)
Exon count:
17
Annotation release | Status | Assembly | Chr | Location |
---|---|---|---|---|
RS_2024_08 | current | GRCh38.p14 (GCF_000001405.40) | X | NC_000023.11 (136146702..136211359) |
RS_2024_08 | current | T2T-CHM13v2.0 (GCF_009914755.1) | X | NC_060947.1 (134455091..134519750) |
RS_2024_09 | previous assembly | GRCh37.p13 (GCF_000001405.25) | X | NC_000023.10 (135228861..135293518) |
Chromosome X - NC_000023.11
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RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in [Genomic regions, transcripts, and products](#geneGenomic regions, transcripts, and products) above.
Genomic
- NG_015895.1 RefSeqGene
Range
5134..68955
Download
GenBank, FASTA, Sequence Viewer (Graphics), LRG_739
mRNA and Protein(s)
- NM_001159699.2 → NP_001153171.1 four and a half LIM domains protein 1 isoform 5
See identical proteins and their annotated locations for NP_001153171.1
Status: REVIEWED
Description
Transcript Variant: This variant (7) differs in the 5' UTR, 3' UTR, and 3' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 5) has distinct N- and C-termini and is shorter than isoform 1.
Source sequence(s)
[BC088369, BM995585, DC373386](/nuccore/BC088369, BM995585, DC373386)
Consensus CDS
CCDS55506.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000359717.1, ENST00000370683.6
Conserved Domains (5) summary
cd09344
Location:56 → 109
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:233 → 296
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:117 → 174
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:178 → 230
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:21 → 49
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001159700.2 → NP_001153172.1 four and a half LIM domains protein 1 isoform 2
See identical proteins and their annotated locations for NP_001153172.1
Status: REVIEWED
Description
Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
Source sequence(s)
[AK304680, AL078638, BC088369, BM995585, DC363191](/nuccore/AK304680, AL078638, BC088369, BM995585, DC363191)
Consensus CDS
CCDS14655.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000485897.1, ENST00000630084.2
Conserved Domains (5) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:217 → 280
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001159701.2 → NP_001153173.1 four and a half LIM domains protein 1 isoform 3 precursor
See identical proteins and their annotated locations for NP_001153173.1
Status: REVIEWED
Description
Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has distinct N- and C-termini, compared to isoform 1.
Source sequence(s)
[AK301642, BC010998, BM995585](/nuccore/AK301642, BC010998, BM995585)
Consensus CDS
CCDS55505.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000437673.1, ENST00000539015.5
Conserved Domains (5) summary
cd09344
Location:69 → 122
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:246 → 309
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:130 → 187
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:191 → 243
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:34 → 62
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001159702.3 → NP_001153174.1 four and a half LIM domains protein 1 isoform 1
See identical proteins and their annotated locations for NP_001153174.1
Status: REVIEWED
Description
Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
Source sequence(s)
[AF063002, AF098518, BC010998, BM995585](/nuccore/AF063002, AF098518, BC010998, BM995585)
Consensus CDS
CCDS55507.1
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Related
ENSP00000377710.2, ENST00000394155.8
Conserved Domains (4) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001159703.2 → NP_001153175.1 four and a half LIM domains protein 1 isoform 4
See identical proteins and their annotated locations for NP_001153175.1
Status: REVIEWED
Description
Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
Source sequence(s)
[AF220153, AK301642, AL078638, BC010998, BE965488, BM995585, DA497183](/nuccore/AF220153, AK301642, AL078638, BC010998, BE965488, BM995585, DA497183)
Consensus CDS
CCDS76036.1
UniProtKB/TrEMBL
A0A0D9SFZ9
Related
ENSP00000477609.1, ENST00000618438.4
Conserved Domains (3) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001159704.1 → NP_001153176.1 four and a half LIM domains protein 1 isoform 2
See identical proteins and their annotated locations for NP_001153176.1
Status: REVIEWED
Description
Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
Source sequence(s)
[AK122708, AL078638, BM995585](/nuccore/AK122708, AL078638, BM995585)
Consensus CDS
CCDS14655.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000443333.1, ENST00000543669.5
Conserved Domains (5) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:217 → 280
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001167819.1 → NP_001161291.1 four and a half LIM domains protein 1 isoform 2
See identical proteins and their annotated locations for NP_001161291.1
Status: REVIEWED
Description
Transcript Variant: This variant (9) uses a different segment for its 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
Source sequence(s)
[BC010998, BM995585, DA917361, DA982372](/nuccore/BC010998, BM995585, DA917361, DA982372)
Consensus CDS
CCDS14655.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000377709.2, ENST00000394153.6
Conserved Domains (5) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:217 → 280
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001330659.2 → NP_001317588.1 four and a half LIM domains protein 1 isoform 6
Status: REVIEWED
Description
Transcript Variant: This variant (10) uses an alternate 5'-terminal exon, lacks two in-frame exons in the 3' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
Source sequence(s)
AL078638
Consensus CDS
CCDS83493.1
UniProtKB/TrEMBL
A0A0D9SFZ9, Q5JXI2
Related
ENSP00000359710.3, ENST00000370676.7
Conserved Domains (3) summary
cd09344
Location:56 → 109
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:117 → 174
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:21 → 49
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001369326.1 → NP_001356255.1 four and a half LIM domains protein 1 isoform 1
Status: REVIEWED
Source sequence(s)
AL078638
Consensus CDS
CCDS55507.1
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Related
ENSP00000498684.1, ENST00000651089.1
Conserved Domains (4) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001369327.2 → NP_001356256.1 four and a half LIM domains protein 1 isoform 1
Status: REVIEWED
Source sequence(s)
AL078638
Consensus CDS
CCDS55507.1
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Conserved Domains (4) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001369328.1 → NP_001356257.1 four and a half LIM domains protein 1 isoform 1
Status: REVIEWED
Source sequence(s)
AL078638
Consensus CDS
CCDS55507.1
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Conserved Domains (4) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001369329.1 → NP_001356258.1 four and a half LIM domains protein 1 isoform 2
Status: REVIEWED
Source sequence(s)
AL078638
Consensus CDS
CCDS14655.1
UniProtKB/TrEMBL
Q53FI7
Conserved Domains (5) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:217 → 280
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001369330.1 → NP_001356259.1 four and a half LIM domains protein 1 isoform 2
Status: REVIEWED
Source sequence(s)
AL078638
Consensus CDS
CCDS14655.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000444815.1, ENST00000535737.5
Conserved Domains (5) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:217 → 280
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001369331.1 → NP_001356260.1 four and a half LIM domains protein 1 isoform 2
Status: REVIEWED
Source sequence(s)
AL078638
Consensus CDS
CCDS14655.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000359708.1, ENST00000370674.3
Conserved Domains (5) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:217 → 280
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - NM_001449.5 → NP_001440.2 four and a half LIM domains protein 1 isoform 2
See identical proteins and their annotated locations for NP_001440.2
Status: REVIEWED
Description
Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
Source sequence(s)
[BC010998, BM995585](/nuccore/BC010998, BM995585)
Consensus CDS
CCDS14655.1
UniProtKB/TrEMBL
Q53FI7
Related
ENSP00000499016.1, ENST00000651929.2
Conserved Domains (5) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09348
Location:217 → 280
LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
RNA
- NR_027621.2 RNA Sequence
Status: REVIEWED
Description
Transcript Variant: This variant (8) includes an additional exon at the 5' end, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that is predicted to interfere with translation of the downstream expected ORF as used in variant 1.
Source sequence(s)
[AK289411, AL078638, BC010998, BM995585](/nuccore/AK289411, AL078638, BC010998, BM995585)
RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08
The following sections contain reference sequences that belong to a specific genome build. Explain
This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
- NC_000023.11 Reference GRCh38.p14 Primary Assembly
Range
136146702..136211359
Download
GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
- XM_047441926.1 → XP_047297882.1 four and a half LIM domains protein 1 isoform X2
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630 - XM_047441927.1 → XP_047297883.1 four and a half LIM domains protein 1 isoform X3
- XM_024452354.2 → XP_024308122.1 four and a half LIM domains protein 1 isoform X2
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Conserved Domains (4) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - XM_047441925.1 → XP_047297881.1 four and a half LIM domains protein 1 isoform X2
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630 - XM_006724743.3 → XP_006724806.1 four and a half LIM domains protein 1 isoform X1
See identical proteins and their annotated locations for XP_006724806.1
Conserved Domains (4) summary
cd09344
Location:56 → 109
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:117 → 174
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:178 → 230
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:21 → 49
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers - XM_006724746.4 → XP_006724809.1 four and a half LIM domains protein 1 isoform X2
See identical proteins and their annotated locations for XP_006724809.1
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Conserved Domains (4) summary
cd09344
Location:40 → 93
LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
cd09424
Location:101 → 158
LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
cd09429
Location:162 → 214
LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
cl02475
Location:5 → 33
LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Alternate T2T-CHM13v2.0
Genomic
- NC_060947.1 Alternate T2T-CHM13v2.0
Range
134455091..134519750
Download
GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
- XM_054326701.1 → XP_054182676.1 four and a half LIM domains protein 1 isoform X2
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630 - XM_054326702.1 → XP_054182677.1 four and a half LIM domains protein 1 isoform X3
- XM_054326700.1 → XP_054182675.1 four and a half LIM domains protein 1 isoform X2
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630 - XM_054326699.1 → XP_054182674.1 four and a half LIM domains protein 1 isoform X2
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630 - XM_054326697.1 → XP_054182672.1 four and a half LIM domains protein 1 isoform X1
- XM_054326698.1 → XP_054182673.1 four and a half LIM domains protein 1 isoform X2
UniProtKB/Swiss-Prot
B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630