MPO myeloperoxidase [Homo sapiens (human)] - Gene (original) (raw)

Official Symbol

MPOprovided by HGNC

Official Full Name

myeloperoxidaseprovided by HGNC

Primary source

HGNC:HGNC:7218

See related

Ensembl:ENSG00000005381 MIM:606989; AllianceGenome:HGNC:7218

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Summary

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

Expression

Restricted expression toward bone marrow (RPKM 1596.3) See more

Orthologs

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Exon count:

12

Chromosome 17 - NC_000017.11

• Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
• Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
• BioProject: PRJEB4337
• Publication:PMID 24309898
• Analysis date: Wed Apr 4 07:08:55 2018

Related articles in PubMed

1. Myeloperoxidase, subclinical atherosclerosis, and cardiovascular disease events. Wong ND, et al. JACC Cardiovasc Imaging, 2009 Sep. PMID 19761988
2. Myeloperoxidase expression in early life. On the causal pathways for atherosclerosis? Charakida M, et al. Atherosclerosis, 2009 Jul. PMID 19410253
3. Myeloperoxidase concentrations in EDTA-plasma of healthy subjects are discordant with concentrations in heparin-plasma and serum. Scheffer PG, et al. Clin Biochem, 2009 Sep. PMID 19524564
4. The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the -129A allele in women. Zotova E, et al. Coron Artery Dis, 2009 Aug. PMID 19543083
5. Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification? Schindhelm RK, et al. Clin Chem, 2009 Aug. PMID 19556446

See all (678) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. [The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].
   Title: [The auxiliary diagnostic value of ECP and MPO expression in nasal secretions in different types of rhinitis].
2. The effect of fetal hypoxia on myeloperoxidase levels in cord blood: a prospective study.
   Title: The effect of fetal hypoxia on myeloperoxidase levels in cord blood: a prospective study.
3. Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases.
   Title: Treatment regimens and disease activity could alter salivary myeloperoxidase levels in patients with inflammatory bowel diseases.
4. Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer.
   Title: Monomeric myeloperoxidase is a specific biomarker for early-stage ovarian cancer.
5. Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells.
   Title: Myeloperoxidase enhances the migration and invasion of human choriocarcinoma JEG-3 cells.
6. Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
   Title: Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
7. Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review.
   Title: Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review.
8. Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.
   Title: Relationship between disease severity and myeloperoxidase in chronic viral hepatitis: a prospective study.
9. Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation.
   Title: Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation.
10. NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.
    Title: NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease.

Replication interactions

Protein interactions

Go to the HIV-1, Human Interaction Database

Markers

• RH45018 (e-PCR)
  • UniSTS:2825
• D17S1716 (e-PCR)
  • UniSTS:18188
• GDB:178575 (e-PCR)
  • UniSTS:155027
• GDB:196134 (e-PCR)
  • UniSTS:155816
• STS-M19507 (e-PCR)
  • UniSTS:18371
• D17S1975 (e-PCR)
  • UniSTS:33742
• GDB:180938 (e-PCR)
  • UniSTS:155132
• GDB:191092 (e-PCR)
  • UniSTS:155644

Preferred Names

myeloperoxidase

NP_000241.1

• EC 1.11.2.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in [Genomic regions, transcripts, and products](#geneGenomic regions, transcripts, and products) above.

Genomic

1. NG_009629.1 RefSeqGene
   Range
   5001..16080
   Download
   GenBank, FASTA, Sequence Viewer (Graphics), LRG_84

mRNA and Protein(s)

1. NM_000250.2 → NP_000241.1 myeloperoxidase precursor
   See identical proteins and their annotated locations for NP_000241.1
   Status: REVIEWED
   Source sequence(s)
   [AC004687, M19507](/nuccore/AC004687, M19507)
   Consensus CDS
   CCDS11604.1
   UniProtKB/Swiss-Prot
   A1L4B8, P05164, Q14862, Q4PJH5, Q9UCL7
   Related
   ENSP00000225275.3, ENST00000225275.4
   Conserved Domains (1) summary
   cd09824
   Location:316 → 728
   myeloperoxidase_like; Myeloperoxidases, eosinophil peroxidases, and lactoperoxidases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000017.11 Reference GRCh38.p14 Primary Assembly
   Range
   58269855..58280935 complement
   Download
   GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

1. NC_060941.1 Alternate T2T-CHM13v2.0
   Range
   59137736..59148814 complement
   Download
   GenBank, FASTA, Sequence Viewer (Graphics)