MBOAT7 membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 [Homo sapiens (human)] - Gene (original) (raw)

Official Symbol

MBOAT7provided by HGNC

Official Full Name

membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7provided by HGNC

Primary source

HGNC:HGNC:15505

See related

Ensembl:ENSG00000125505 MIM:606048; AllianceGenome:HGNC:15505

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

BB1; LRC4; LENG4; LPIAT; LPLAT; MBOA7; MRT57; OACT7; LPIAT1; LPLAT11; hMBOA-7

Summary

This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Expression

Ubiquitous expression in testis (RPKM 19.3), adrenal (RPKM 15.7) and 25 other tissues See more

Orthologs

all

Try the new Gene page
Try the new Transcripts and proteins table

Exon count:

8

Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54173415..54189580, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57253615..57269968, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54677109..54693431, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes

  1. MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD. Meroni M, et al. EBioMedicine, 2020 Jul. PMID 32629394, Free PMC Article
  2. A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes. Alharthi J, et al. Nat Commun, 2022 Dec 6. PMID 36473860, Free PMC Article
  3. Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease. Varadharajan V, et al. J Lipid Res, 2022 Jul. PMID 35636492, Free PMC Article
  4. Expression of Membrane Bound O-Acyltransferase Domain Containing 7 after Myocardial Infarction and its Role in Lipid Metabolism in vitro. Li X, et al. Int J Med Sci, 2022. PMID 35582424, Free PMC Article
  5. Mutations in MBOAT7, Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features. Johansen A, et al. Am J Hum Genet, 2016 Oct 6. PMID 27616480, Free PMC Article

See all (129) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

  1. A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on Immune Cells.
    Title: A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on Immune Cells.
  2. Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
    Title: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
  3. Exome sequencing identifies homozygous variants in MBOAT7 associated with neurodevelopmental disorder.
    Title: Exome sequencing identifies homozygous variants in MBOAT7 associated with neurodevelopmental disorder.
  4. MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort.
    Title: MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort.
  5. MBOAT7 expression is associated with disease progression in COVID-19 patients.
    Title: MBOAT7 expression is associated with disease progression in COVID-19 patients.
  6. MBOAT7 in liver and extrahepatic diseases.
    Title: MBOAT7 in liver and extrahepatic diseases.
  7. MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis.
    Title: MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis.
  8. Effects of MBOAT7 polymorphism and steatosis on liver function assessed by methacetin breath test.
    Title: Effects of MBOAT7 polymorphism and steatosis on liver function assessed by methacetin breath test.
  9. MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population.
    Title: MBOAT7 rs641738 (C>T) is associated with NAFLD progression in men and decreased ASCVD risk in elder Chinese population.
  10. A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes.
    Title: A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes.

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Preferred Names

membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

Names

1-acylglycerophosphatidylinositol O-acyltransferase

LPLAT 7

bladder and breast carcinoma-overexpressed gene 1 protein

h-mboa-7

leukocyte receptor cluster (LRC) member 4

lyso-PI acyltransferase

lysophosphatidylinositol acyltransferase

lysophosphatidylinositol acyltransferase 1

lysophospholipid acyltransferase 11

lysophospholipid acyltransferase 7

malignant cell expression-enhanced gene/tumor progression-enhanced

membrane bound O-acyltransferase domain containing 7

NP_001139528.1

NP_001139554.1

NP_001139555.1

NP_077274.3

XP_011525601.1

XP_011525602.1

XP_054178092.1

XP_054178093.1

XP_054185677.1

XP_054185678.1

XP_054186179.1

XP_054186475.1

XP_054186725.1

XP_054186956.1

XP_054187239.1

XP_054187508.1

XP_054187509.1

XP_054189553.1

XP_054189655.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in [Genomic regions, transcripts, and products](#geneGenomic regions, transcripts, and products) above.

Genomic

  1. NG_033045.2 RefSeqGene
    Range
    5296..21461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001146056.3 → NP_001139528.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform 2
    See identical proteins and their annotated locations for NP_001139528.1
    Status: REVIEWED
    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    [AI032483, AK298689, BQ045276, DA338950](/nuccore/AI032483, AK298689, BQ045276, DA338950)
    Consensus CDS
    CCDS54315.1
    UniProtKB/Swiss-Prot
    Q96N66
    Related
    ENSP00000344377.5, ENST00000338624.10
    Conserved Domains (1) summary
    cl00738
    Location:55 → 361
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
  2. NM_001146082.3 → NP_001139554.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform 3
    Status: REVIEWED
    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    [AC245052, AK055908, BC003164, CB240899, DA338950](/nuccore/AC245052, AK055908, BC003164, CB240899, DA338950)
    Consensus CDS
    CCDS54316.1
    UniProtKB/Swiss-Prot
    Q96N66
    Related
    ENSP00000375634.1, ENST00000391754.5
    Conserved Domains (1) summary
    cl00738
    Location:2 → 333
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
  3. NM_001146083.3 → NP_001139555.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform 2
    See identical proteins and their annotated locations for NP_001139555.1
    Status: REVIEWED
    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    [AI032483, BC015857, BQ045276, DA338950](/nuccore/AI032483, BC015857, BQ045276, DA338950)
    Consensus CDS
    CCDS54315.1
    UniProtKB/Swiss-Prot
    Q96N66
    Related
    ENSP00000410503.2, ENST00000431666.6
    Conserved Domains (1) summary
    cl00738
    Location:55 → 361
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
  4. NM_024298.5 → NP_077274.3 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform 1
    See identical proteins and their annotated locations for NP_077274.3
    Status: REVIEWED
    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    [AI032483, AK055908, BC003164, BQ045276, DA338950](/nuccore/AI032483, AK055908, BC003164, BQ045276, DA338950)
    Consensus CDS
    CCDS12883.1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8
    Related
    ENSP00000245615.1, ENST00000245615.6
    Conserved Domains (1) summary
    cl00738
    Location:2 → 431
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly
    Range
    54173415..54189580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527299.4 → XP_011525601.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    See identical proteins and their annotated locations for XP_011525601.1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8
    Related
    ENSP00000532679.1, ENST00000862620.1
    Conserved Domains (1) summary
    cl00738
    Location:2 → 431
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
  2. XM_011527300.3 → XP_011525602.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    See identical proteins and their annotated locations for XP_011525602.1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8
    Conserved Domains (1) summary
    cl00738
    Location:2 → 431
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1
    Range
    148187..164377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329702.1 → XP_054185677.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8
  2. XM_054329703.1 → XP_054185678.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2
    Range
    148223..164545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330204.1 → XP_054186179.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3
    Range
    148223..164545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330500.1 → XP_054186475.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4
    Range
    148223..164545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330750.1 → XP_054186725.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5
    Range
    148223..164545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330981.1 → XP_054186956.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6
    Range
    148223..164545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331264.1 → XP_054187239.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7
    Range
    148193..164544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331533.1 → XP_054187508.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8
  2. XM_054331534.1 → XP_054187509.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8
    Range
    148223..164545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333578.1 → XP_054189553.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9
    Range
    148223..164545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333680.1 → XP_054189655.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0
    Range
    57253615..57269968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322118.1 → XP_054178093.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8
  2. XM_054322117.1 → XP_054178092.1 membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform X1
    UniProtKB/Swiss-Prot
    A9C4B6, B0V3I5, B4DQ87, Q05DF0, Q7L5N2, Q96N66, Q99908, Q9BPV2, Q9BRE9
    UniProtKB/TrEMBL
    B4DDH8