FRMPD3 FERM and PDZ domain containing 3 [Homo sapiens (human)] - Gene (original) (raw)

Exon count:

19

Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (107449652..107605251)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (105886268..106042004)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106692882..106848481)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in [Genomic regions, transcripts, and products](#geneGenomic regions, transcripts, and products) above.

mRNA and Protein(s)

  1. NM_001388459.1 → NP_001375388.1 FERM and PDZ domain-containing protein 3 isoform 1
    Status: REVIEWED
    Source sequence(s)
    [AL035088, AL137787](/nuccore/AL035088, AL137787)
    Consensus CDS
    CCDS94646.1
    UniProtKB/Swiss-Prot
    A0A804HKI5, Q5JV73, Q96JK8
    UniProtKB/TrEMBL
    A0A0A0MSP7
    Related
    ENSP00000507942.1, ENST00000683843.1
    Conserved Domains (4) summary
    smart00295
    Location:148 → 367
    B41; Band 4.1 homologues
    cd00992
    Location:19 → 95
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:363 → 466
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:145 → 237
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)
  2. NM_001388462.1 → NP_001375391.1 FERM and PDZ domain-containing protein 3 isoform 2
    Status: REVIEWED
    Source sequence(s)
    [AL035088, AL137787](/nuccore/AL035088, AL137787)
    Consensus CDS
    CCDS94647.1
    UniProtKB/TrEMBL
    A0A0A0MSP7, A0A804HJA6
    Conserved Domains (3) summary
    smart00295
    Location:13 → 232
    B41; Band 4.1 homologues
    cd13183
    Location:228 → 331
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:10 → 102
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)
  3. NM_032428.2 → NP_115804.1 FERM and PDZ domain-containing protein 3 isoform 3
    See identical proteins and their annotated locations for NP_115804.1
    Status: REVIEWED
    Source sequence(s)
    [AL035088, AL137787](/nuccore/AL035088, AL137787)
    UniProtKB/TrEMBL
    A0A0A0MSP7
    Conserved Domains (5) summary
    smart00295
    Location:181 → 400
    B41; Band 4.1 homologues
    cd00992
    Location:52 → 128
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:396 → 499
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    pfam00373
    Location:276 → 400
    FERM_M; FERM central domain
    pfam15710
    Location:1000 → 1378
    DUF4671; Domain of unknown function (DUF4671)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly
    Range
    107449652..107605251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029902.3 → XP_016885391.1 FERM and PDZ domain-containing protein 3 isoform X1
    UniProtKB/TrEMBL
    A0A0A0MSP7
  2. XM_006724709.4 → XP_006724772.1 FERM and PDZ domain-containing protein 3 isoform X5
    See identical proteins and their annotated locations for XP_006724772.1
    UniProtKB/TrEMBL
    A0A0A0MSP7
    Conserved Domains (4) summary
    smart00295
    Location:3 → 195
    B41; Band 4.1 homologues
    cd13183
    Location:191 → 294
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    pfam00373
    Location:71 → 195
    FERM_M; FERM central domain
    pfam15710
    Location:795 → 1173
    DUF4671; Domain of unknown function (DUF4671)
  3. XM_011531056.4 → XP_011529358.1 FERM and PDZ domain-containing protein 3 isoform X2
    UniProtKB/TrEMBL
    A0A0A0MSP7
    Conserved Domains (4) summary
    smart00295
    Location:50 → 269
    B41; Band 4.1 homologues
    cd13183
    Location:265 → 368
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    pfam00373
    Location:145 → 269
    FERM_M; FERM central domain
    pfam15710
    Location:869 → 1247
    DUF4671; Domain of unknown function (DUF4671)
  4. XM_011531057.4 → XP_011529359.1 FERM and PDZ domain-containing protein 3 isoform X3
    UniProtKB/TrEMBL
    A0A0A0MSP7
    Conserved Domains (4) summary
    smart00295
    Location:46 → 265
    B41; Band 4.1 homologues
    cd13183
    Location:261 → 364
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    pfam00373
    Location:141 → 265
    FERM_M; FERM central domain
    pfam15710
    Location:865 → 1243
    DUF4671; Domain of unknown function (DUF4671)
  5. XM_011531058.4 → XP_011529360.1 FERM and PDZ domain-containing protein 3 isoform X4
    UniProtKB/TrEMBL
    A0A0A0MSP7, A0A804HJA6
    Related
    ENSP00000507422.1, ENST00000684358.1
    Conserved Domains (3) summary
    smart00295
    Location:13 → 232
    B41; Band 4.1 homologues
    cd13183
    Location:228 → 331
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:10 → 102
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0
    Range
    105886268..106042004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327971.1 → XP_054183946.1 FERM and PDZ domain-containing protein 3 isoform X1
  2. XM_054327975.1 → XP_054183950.1 FERM and PDZ domain-containing protein 3 isoform X5
  3. XM_054327972.1 → XP_054183947.1 FERM and PDZ domain-containing protein 3 isoform X2
  4. XM_054327973.1 → XP_054183948.1 FERM and PDZ domain-containing protein 3 isoform X3
  5. XM_054327974.1 → XP_054183949.1 FERM and PDZ domain-containing protein 3 isoform X4
    UniProtKB/TrEMBL
    A0A804HJA6