Vitamin A-containing lipocytes and formation of type III collagen in liver injury (original) (raw)
Abstract
Hepatocellular necrosis in carbon tetracholride-induced injury of rats is associated with an accumulation of lipocytes (perisinusoidal cells or Ito cells) containing fat droplets and giving vitamin A fluorescence. In the subsequent formation of connective tissue septa, transitional cells having morphologic characteristics of lipocytes and fibroblasts are abundant and are associated with the appearance of type III collage-. The features suggest that the lipocyte is the precursor of the fibroblasts responsible for parenchymal fibrillogenesis and under these conditions forms type III collagen. The process is a postulated link between hepatocellular necrosis and fibrosis.
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Selected References
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- Bronfenmajer S., Schaffner F., Popper H. Fat-storing cells (lipocytes) in human liver. Arch Pathol. 1966 Nov;82(5):447–453. [PubMed] [Google Scholar]
- Gay S., Fietzek P. P., Remberger K., Eder M., Kühn K. Liver cirrhosis: immunofluorescence and biochemical studies demonstrate two types of collagen. Klin Wochenschr. 1975 Mar 1;53(5):205–208. doi: 10.1007/BF01468808. [DOI] [PubMed] [Google Scholar]
- Hruban Z., Russell R. M., Boyer J. L., Glagov S., Bagheri S. A. Ultrastructural changes in livers of two patients with hypervitaminosis A. Am J Pathol. 1974 Sep;76(3):451–461. [PMC free article] [PubMed] [Google Scholar]
- ITO T., NEMOTO M. Uber die Kupfferschen Sternzellen und die Fettspeicherungszellen (fat storing cells) in der Blutkapillarenwand der memschlichen Leber. Okajimas Folia Anat Jpn. 1952 Oct;24(4):243–258. doi: 10.2535/ofaj1936.24.4_243. [DOI] [PubMed] [Google Scholar]
- McGee J. O., O'Hare R. P., Patrick R. S. Stimulation of the collagen biosynthetic pathway by factors isolated from experimentally-injured liver. Nat New Biol. 1973 May 23;243(125):121–123. [PubMed] [Google Scholar]
- McGee J. O., Patrick R. S. The role of perisinusoidal cells in hepatic fibrogenesis. An electron microscopic study of acute carbon tetrachloride liver injury. Lab Invest. 1972 Apr;26(4):429–440. [PubMed] [Google Scholar]
- Miller E. J., Matukas V. J. Biosynthesis of collagen. The biochemist's view. Fed Proc. 1974 May;33(5):1197–1204. [PubMed] [Google Scholar]
- Popper H., Kent G. Fibrosis in chronic liver disease. Clin Gastroenterol. 1975 May;4(2):315–332. [PubMed] [Google Scholar]
- Popper H., Uenfriend S. Hepatic fibrosis. Correlation of biochemical and morphologic investigations. Am J Med. 1970 Nov;49:707–721. doi: 10.1016/s0002-9343(70)80135-8. [DOI] [PubMed] [Google Scholar]
- Rave O., Wagner H., Junge-Hülsing G., Hauss W. H. Tierexperimentelle Untersuchungen über die Wirkung von Vitamin A auf den Bendegewebsstoffwechsel. Z Rheumaforsch. 1972 Jul-Aug;31(7):245–253. [PubMed] [Google Scholar]
- Rojkind M., Martinez-Palomo A. Increase in type I and type III collagens in human alcoholic liver cirrhosis. Proc Natl Acad Sci U S A. 1976 Feb;73(2):539–543. doi: 10.1073/pnas.73.2.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schnack H., Stockinger L., Wewalka F. Adventitious connective tissue cells in the space of Disse and their relation to fibre formation. Rev Int Hepatol. 1967;17(8):855–860. [PubMed] [Google Scholar]
- Sudhakaran P. R., Kurup P. A. Vitamin A and glycosaminoglycan metabolism in rats. J Nutr. 1974 Jul;104(7):871–883. doi: 10.1093/jn/104.7.871. [DOI] [PubMed] [Google Scholar]
- Wake K. Development of vitamin A-rich lipid droplets in multivesicular bodies of rat liver stellate cells. J Cell Biol. 1974 Nov;63(2 Pt 1):683–691. doi: 10.1083/jcb.63.2.683. [DOI] [PMC free article] [PubMed] [Google Scholar]