Mechanisms of resistant of herpesviruses: comparison of the effectiveness of different cell types in mediating antibody-dependent cell-mediated cytotoxicity (original) (raw)

Abstract

Enriched populations of polymorphonuclear leukocytes (PMN) and macrophages obtained from the mammary gland and of granulocytes (PBG) and lymphocytes (PBL) prepared from peripheral blood of the same animal were compared for their ability to mediate antibody-dependent cell cytotoxocity against antibody-sensitized infectious bovine rhinotracheitis virus-infected target cells (IBR-GBK) and antibody-sensitized chicken erythrocyte targest (CRBC). The order of effectiveness was PMN leads to macrophages leads to PBG leads to PBL. The reason why PBG (86% PMN) were less than 50% as active as mammary PMN (99% PMN) was explored and discussed. The findings that PMN were more effective on a cell-to-cell basis, required less antiserum to sensitize for cytotoxicity, and destroyed IBR-GBK cells faster and more completely than other cell types could mean that PMN may be the cell type most importnat in causing early recovery from herpesvirus infections.

698

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Butterworth A. E., Sturrock R. F., Houba V., Mahmoud A. A., Sher A., Rees P. H. Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature. 1975 Aug 28;256(5520):727–729. doi: 10.1038/256727a0. [DOI] [PubMed] [Google Scholar]
  2. COHN Z. A., BENSON B. THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY. J Exp Med. 1965 Jan 1;121:153–170. doi: 10.1084/jem.121.1.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Calder E. A., Penhale W. J., McLeman D., Barnes E. W., Irvine W. J. Lymphocyte-dependent antibody-mediated cytotoxicity in Hashimoto thyroiditis. Clin Exp Immunol. 1973 Jun;14(2):153–158. [PMC free article] [PubMed] [Google Scholar]
  4. Gale R. P., Zighelboim J. Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity. J Immunol. 1975 Mar;114(3):1047–1051. [PubMed] [Google Scholar]
  5. Hellström I., Hellström K. E., Warner G. A. Increase of lymphocyte-mediated tumor-cell destruction by certain patient sera. Int J Cancer. 1973 Sep 15;12(2):348–353. doi: 10.1002/ijc.2910120205. [DOI] [PubMed] [Google Scholar]
  6. MacDonald H. R., Bonnard G. D., Sordat B., Zawodnik S. A. Antibody-dependent cell-mediated cytotoxicity: heterogeneity of effector cells in human peripheral blood. Scand J Immunol. 1975 Sep;4(5-6):487–497. doi: 10.1111/j.1365-3083.1975.tb02654.x. [DOI] [PubMed] [Google Scholar]
  7. MacLennan I. C. Antibody in the induction and inhibition of lymphocyte cytotoxicity. Transplant Rev. 1972;13:67–90. doi: 10.1111/j.1600-065x.1972.tb00060.x. [DOI] [PubMed] [Google Scholar]
  8. Perlmann P., Perlmann H., Wigzell H. Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells. Transplant Rev. 1972;13:91–114. doi: 10.1111/j.1600-065x.1972.tb00061.x. [DOI] [PubMed] [Google Scholar]
  9. Pollack S., Heppner G., Brawn R. J., Nelson K. Specific killing of tumor cells in vitro in the presence of normal lymphoid cells and sera from hosts immune to the tumor antigens. Int J Cancer. 1972 Mar 15;9(2):316–323. doi: 10.1002/ijc.2910090209. [DOI] [PubMed] [Google Scholar]
  10. Rager-Zisman B., Bloom B. R. Immunological destruction of herpes simplex virus I infected cells. Nature. 1974 Oct 11;251(5475):542–543. doi: 10.1038/251542a0. [DOI] [PubMed] [Google Scholar]
  11. Rhodes J. Macrophage heterogeneity in receptor activity: the activation of macrophage Fc receptor function in vivo and in vitro. J Immunol. 1975 Mar;114(3):976–981. [PubMed] [Google Scholar]
  12. Rouse B. T., Babiuk L. A. Host defense mechanisms against infectious bovine rhinotracheitis virus: in vitro stimulation of sensitized lymphocytes by virus antigen. Infect Immun. 1974 Oct;10(4):681–687. doi: 10.1128/iai.10.4.681-687.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rouse B. T., Wardley R. C., Babiuk L. A. Antibody-dependent cell-mediated cytotoxicity in cows: comparison of effector cell activity against heterologous erthrocyte and herpesvirus-infected bovine target cells. Infect Immun. 1976 May;13(5):1433–1441. doi: 10.1128/iai.13.5.1433-1441.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rouse B. T., Wardley R. C., Babiuk L. A. The role of antibody dependent cytotoxicity in recovery from herpesvirus infections. Cell Immunol. 1976 Mar 1;22(1):182–186. doi: 10.1016/0008-8749(76)90019-8. [DOI] [PubMed] [Google Scholar]
  15. Sanderson C. J., Taylor G. A. Antibody-dependent cell-mediated cytotoxicity in the rat. The role of macrophages. Immunology. 1976 Jan;30(1):117–121. [PMC free article] [PubMed] [Google Scholar]
  16. Shore S. L., Nahmias A. J., Starr S. E., Wood P. A., McFarlin D. E. Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus. Nature. 1974 Sep 27;251(5473):350–352. doi: 10.1038/251350a0. [DOI] [PubMed] [Google Scholar]
  17. Skurzak H. M., Klein E., Yoshida T. O., Lamon E. W. Synergistic or antgonistic effect of different antibody concentrations on in vitro lymphocyte cytotoxicity in the Moloney sarcoma virus system. J Exp Med. 1972 Apr 1;135(4):997–1002. doi: 10.1084/jem.135.4.997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wardley R. C., Rouse B. T., Babiuk L. A. Antibody dependent cytotoxicity mediated by neutrophils: a possible mechanism of antiviral defense. J Reticuloendothel Soc. 1976 May;19(5):323–332. [PubMed] [Google Scholar]
  19. Wardley R. C., Rouse B. T., Babiuk L. A. The mammary gland of the ox: a convenient source for the repeated collection of neutrophils and macrophages. J Reticuloendothel Soc. 1976 Jan;19(1):29–36. [PubMed] [Google Scholar]
  20. Yust I., Smith R. W., Wunderlich J. R., Mann D. L. Temporary inhibition of antibody-dependent, cell-mediated cytotoxicity by pretreatment of human attacking cells with ammonium chloride. J Immunol. 1976 Apr;116(4):1170–1172. [PubMed] [Google Scholar]