Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors (original) (raw)

Abstract

Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.

Keywords: Cancer Research, Direct Evidence, Fibrosarcoma, Suppressor Cell, Antitumor Immunity

Footnotes

This work was supported by Grants CA-16642 and CA-17794 from the National Cancer Institute, Grant RR-05705 from the Division of Research Resources, NIH, and a grant from R. J. Reynolds Industries, Inc

References

• 1.Berendt MJ, North RJ. T cell-mediated suppression of antitumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med. 1980;151:69. doi: 10.1084/jem.151.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
• 2.Bonventre PF, Nikol AD, Ball EJ, Michael JG, Bubel HC. Development of protective immunity against bacterial and viral infections in tumor-bearing mice coincident with suppression of tumor immunity. J Reticuloendothel Soc. 1982;32:25. [PubMed] [Google Scholar]
• 3.Bursuker I, North RJ. Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell mediated suppression of immunity. J Exp Med. 1984;159:1312. doi: 10.1084/jem.159.5.1312. [DOI] [PMC free article] [PubMed] [Google Scholar]
• 4.Dye ES, North RJ. T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases. J Exp Med. 1981;154:1033. doi: 10.1084/jem.154.4.1033. [DOI] [PMC free article] [PubMed] [Google Scholar]
• 5.Dye ES, North RJ. Specificity of the T cells that mediate and suppress adoptive immunotherapy of established tumors. J Leukocyte Biol. 1984;36:27. doi: 10.1002/jlb.36.1.27. [DOI] [PubMed] [Google Scholar]
• 6.Gorelik E. Concomitant immunity and resistance to a second tumor challenge. Adv Cancer Res. 1983;39:41. doi: 10.1016/s0065-230x(08)61033-7. [DOI] [PubMed] [Google Scholar]
• 7.Ledbetter JA, Herzenberg KA. Xenogeneic monolonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev. 1979;47:63. doi: 10.1111/j.1600-065x.1979.tb00289.x. [DOI] [PubMed] [Google Scholar]
• 8.Mills CD, North RJ. Expression of passively transferred immunity against an established tumor depends on generation of cytolytic T cells in recipients: inhibition by suppressor T cells. J Exp Med. 1983;157:1448. doi: 10.1084/jem.157.5.1448. [DOI] [PMC free article] [PubMed] [Google Scholar]
• 9.North RJ. Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J Exp Med. 1982;155:1063. doi: 10.1084/jem.155.4.1063. [DOI] [PMC free article] [PubMed] [Google Scholar]
• 10.North RJ. γ-Irradiation facilitates the expression of adoptive immunity against established tumors by eliminating suppressor T cells. Cancer Immunol Immunother. 1984;16:175. doi: 10.1007/BF00205425. [DOI] [PMC free article] [PubMed] [Google Scholar]
• 11.North RJ, Bursuker I. Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2− suppressor T cells down-regulate the generation of Ly-1−2+ effector T cells. J Exp Med. 1984;159:1295. doi: 10.1084/jem.159.5.1295. [DOI] [PMC free article] [PubMed] [Google Scholar]
• 12.North RJ, Dye ES, Mills CD. T cell-mediated negative regulation of concomitant antitumor immunity as an obstacle to adoptive immunotherapy of established tumors. In: Fefer F, Goldstein AL, editors. The potential role of T cell populations in cancer therapy. New York: Raven Press; 1982. p. 65. [Google Scholar]
• 13.Prehn RT, Main JM. Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst. 1957;18:769. [PubMed] [Google Scholar]
• 14.Schatten S, Granstein RD, Drebin JA, Greene MI. Suppressor T cells and the immune response to tumors. CRC Crit Rev Immunol. 1984;4:335. [PubMed] [Google Scholar]