Effect of Acycloguanosine Treatment on Acute and Latent Herpes Simplex Infections in Mice (original) (raw)

Antimicrob Agents Chemother. 1979 Apr; 15(4): 554–561.

Hugh J. Field

1_Division of Virology, Department of Pathology, Cambridge University, Cambridge, England_

Susanne E. Bell

1_Division of Virology, Department of Pathology, Cambridge University, Cambridge, England_

Gertrude B. Elion

2_Wellcome Research Laboratories, Burroughs- Wellcome Company, Research Triangle Park, North Carolina 27709_

Anthony A. Nash

1_Division of Virology, Department of Pathology, Cambridge University, Cambridge, England_

Peter Wildy

1_Division of Virology, Department of Pathology, Cambridge University, Cambridge, England_

2_Wellcome Research Laboratories, Burroughs- Wellcome Company, Research Triangle Park, North Carolina 27709_

Abstract

Systemic treatment of mice with the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine [aciclovir]) was found to be highly effective against acute type 1 herpes simplex virus infection of the pinna. The drug ablated clinical signs and reduced virus replication both in tissue local to the inoculation site and within the nervous system. Provided that moderate-sized virus inocula were used, acycloguanosine treatment reduced or prevented the establishment of a latent infection in the dorsal root ganglia relating to the sensory nerve supply of the ear. However, although it aborted artificially produced infections in dorsal root ganglia, acycloguanosine was found not to be effective against the latent infection once established. This finding strongly indicated that latent herpes simplex virus in mice can exist in a nonreplicating form.

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Selected References

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