RecName: Full=D-3-phosphoglycerate dehydrogenase; Short=3-PGDH; AltNam - Protein (original) (raw)
Result Filters
RecName: Full=D-3-phosphoglycerate dehydrogenase; Short=3-PGDH; AltName: Full=2-oxoglutarate reductase; AltName: Full=Malate dehydrogenase
UniProtKB/Swiss-Prot: O43175.4
Identical Proteins FASTA Graphics
Supplemental Content
Change region shown
Whole sequence
Selected region
from: to:
Customize view
Features added by NCBI
Conserved Domains
Analyze this sequence
- Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST. - Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search. - Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... - Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...
Articles about the PHGDH gene
- On the quaternary structure of human D-3-phosphoglycerate dehydrogenase. [Protein Sci. 2024]
On the quaternary structure of human D-3-phosphoglycerate dehydrogenase.
Protein Sci. 2024 Aug; 33(8):e5089. - Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling. [Am J Physiol Endocrinol Metab....]
Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling.
Mäntyselkä S, Kolari K, Baumert P, Ylä-Outinen L, Kuikka L, Lahtonen S, Permi P, Wackerhage H, Kalenius E, Kivelä R, et al. Am J Physiol Endocrinol Metab. 2024 Jan 1; 326(1):E73-E91. Epub 2023 Nov 22. - Biochemical and cellular studies of three human 3-phosphoglycerate dehydrogenase variants responsible for pathological reduced L-serine levels. [Biofactors. 2024]
Biochemical and cellular studies of three human 3-phosphoglycerate dehydrogenase variants responsible for pathological reduced L-serine levels.
Murtas G, Zerbini E, Rabattoni V, Motta Z, Caldinelli L, Orlando M, Marchesani F, Campanini B, Sacchi S, Pollegioni L. Biofactors. 2024 Jan-Feb; 50(1):181-200. Epub 2023 Aug 31.
More about the PHGDH gene
Related information
- PubMed
PubMed articles cited by protein sequence record - Taxonomy
Taxonomy sequences associated with protein record - BioAssay by Target (Summary)
BioAssay by Target (Summary) - BioSystems
BioSystems - CDD Search Results
Display conserved domains within a protein - Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein - Conserved Domains (Full)
Link to conserved domains within a protein - Domain Relatives
Display proteins with similar conserved domain architecture - Full text in PMC
Free full text articles in PMC - Gene
Link to related Genes - Identical Structures
3D structures for identical protein sequences - OMIM
OMIM records associated with protein sequence - Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq) - PubMed (Weighted)
Links to pubmed - Related Structures (List)
List of related structures
LinkOut to external resources
- O43175 [Domain Mapping of Disease Mut...]
O43175
Domain Mapping of Disease Mutations - MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) - Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System - Reactome [Reactome]
Reactome - reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome - reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome - Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site
Recent activity
Finds sub-sequence or patterns in the sequence and highlights the matching region. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences.
More...