Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children - PubMed (original) (raw)

Clinical Trial

Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children

J A Vanderhoof et al. J Pediatr. 1999 Nov.

Abstract

Objective: The objective of this study was to determine the efficacy of Lactobacillus casei sps. rhamnosus (Lactobacillus GG) (LGG) in reducing the incidence of antibiotic-associated diarrhea when coadministered with an oral antibiotic in children with acute infectious disorders.

Study design: Two hundred two children between 6 months and 10 years of age were enrolled; 188 completed all phases of the protocol. LGG, 1 x 10(10) - 2 x 10(10) colony forming units per day, or comparable placebo was administered in a double-blind randomized trial to children receiving oral antibiotic therapy in an outpatient setting. The primary caregiver was questioned every 3 days regarding the incidence of gastrointestinal symptoms, predominantly stool frequency and consistency, through telephone contact by blinded investigators.

Results: Twenty-five placebo-treated but only 7 LGG-treated patients had diarrhea as defined by liquid stools numbering 2 or greater per day. Lactobacillus GG overall significantly reduced stool frequency and increased stool consistency during antibiotic therapy by the tenth day compared with the placebo group.

Conclusion: Lactobacillus GG reduces the incidence of antibiotic-associated diarrhea in children treated with oral antibiotics for common childhood infections.

PubMed Disclaimer

Comment in

• Probiotics plus antibiotics: regulating our bacterial environment.
  Saavedra JM. Saavedra JM. J Pediatr. 1999 Nov;135(5):535-7. doi: 10.1016/s0022-3476(99)70046-6. J Pediatr. 1999. PMID: 10547236 No abstract available.

Similar articles

• Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study.
  Arvola T, Laiho K, Torkkeli S, Mykkänen H, Salminen S, Maunula L, Isolauri E. Arvola T, et al. Pediatrics. 1999 Nov;104(5):e64. doi: 10.1542/peds.104.5.e64. Pediatrics. 1999. PMID: 10545590 Clinical Trial.
• Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A, and Lactobacillus plantarum PL02 in the prevention of antibiotic-associated diarrhea in children: a randomized controlled pilot trial.
  Szymański H, Armańska M, Kowalska-Duplaga K, Szajewska H. Szymański H, et al. Digestion. 2008;78(1):13-7. doi: 10.1159/000151300. Epub 2008 Aug 14. Digestion. 2008. PMID: 18701826 Clinical Trial.
• Lack of effect of Lactobacillus GG on antibiotic-associated diarrhea: a randomized, placebo-controlled trial.
  Thomas MR, Litin SC, Osmon DR, Corr AP, Weaver AL, Lohse CM. Thomas MR, et al. Mayo Clin Proc. 2001 Sep;76(9):883-9. doi: 10.4065/76.9.883. Mayo Clin Proc. 2001. PMID: 11560298 Clinical Trial.
• Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
  Johnston BC, Supina AL, Ospina M, Vohra S. Johnston BC, et al. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD004827. doi: 10.1002/14651858.CD004827.pub2. Cochrane Database Syst Rev. 2007. PMID: 17443557 Updated. Review.
• Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
  Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC. Goldenberg JZ, et al. Cochrane Database Syst Rev. 2015 Dec 22;(12):CD004827. doi: 10.1002/14651858.CD004827.pub4. Cochrane Database Syst Rev. 2015. PMID: 26695080 Updated. Review.

Cited by

• Probiotics for Prevention and Treatment of Clostridium difficile Infection.
  Valdés-Varela L, Gueimonde M, Ruas-Madiedo P. Valdés-Varela L, et al. Adv Exp Med Biol. 2024;1435:101-116. doi: 10.1007/978-3-031-42108-2_6. Adv Exp Med Biol. 2024. PMID: 38175473
• A Comprehensive Overview of the Past, Current, and Future Randomized Controlled Trials in Hepatic Encephalopathy.
  Ilie OD, Duta R, Nita IB, Dobrin I, Gurzu IL, Girleanu I, Huiban L, Muzica C, Ciobica A, Popescu R, Cianga P, Stanciu C, Cimpoesu D, Trifan A. Ilie OD, et al. Medicina (Kaunas). 2023 Dec 10;59(12):2143. doi: 10.3390/medicina59122143. Medicina (Kaunas). 2023. PMID: 38138246 Free PMC article. Review.
• Risk factors of prolonged diarrhea in children under 2 years old.
  Rahmat D, Firmansyah A, Timan IS, Bardosono S, Prihartono J, Gayatri P. Rahmat D, et al. Clin Exp Pediatr. 2023 Dec;66(12):538-544. doi: 10.3345/cep.2023.00668. Epub 2023 Nov 16. Clin Exp Pediatr. 2023. PMID: 37986567 Free PMC article.
• The Effect of Dietary Synbiotics in Actively Racing Standardbred Horses Receiving Trimethoprim/Sulfadiazine.
  Lagounova M, MacNicol JL, Weese JS, Pearson W. Lagounova M, et al. Animals (Basel). 2023 Jul 18;13(14):2344. doi: 10.3390/ani13142344. Animals (Basel). 2023. PMID: 37508120 Free PMC article.
• Role of Probiotics in Human Health.
  Bodke H, Jogdand S. Bodke H, et al. Cureus. 2022 Nov 9;14(11):e31313. doi: 10.7759/cureus.31313. eCollection 2022 Nov. Cureus. 2022. PMID: 36514580 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information