Cognitive correlates of the negative, disorganized, and psychotic symptom dimensions of schizophrenia - PubMed (original) (raw)

. 2000 Winter;12(1):4-15.

doi: 10.1176/jnp.12.1.4.

Affiliations

• PMID: 10678506
• DOI: 10.1176/jnp.12.1.4

Cognitive correlates of the negative, disorganized, and psychotic symptom dimensions of schizophrenia

D S O'Leary et al. J Neuropsychiatry Clin Neurosci. 2000 Winter.

Abstract

Knowledge of the relationship between specific cognitive abnormalities and the clinical symptoms of schizophrenia could give insight into the nature of their underlying pathophysiology. Composite scores were generated for negative, disorganized, and psychotic symptom ratings in 134 patients with schizophrenia (DSM-IV criteria). Partial correlations (each composite corrected for the others) were computed with neuropsychological measures. Negative symptoms were related to poor performance on tests of verbal learning and memory, verbal fluency, visual memory, and visual-motor sequencing. Disorganized symptoms were correlated with lower verbal IQ and poor concept attainment. Psychotic symptoms had no significant relationship with cognitive deficit.

PubMed Disclaimer

Similar articles

• [Psychopathologic and cognitive investigations in schizophrenia].
  Farkas M. Farkas M. Orv Hetil. 2009 Mar 1;150(9):423-9. doi: 10.1556/OH.2009.28530. Orv Hetil. 2009. PMID: 19228571 Hungarian.
• [Interest of a new instrument to assess cognition in schizophrenia: The Brief Assessment of Cognition in Schizophrenia (BACS)].
  Bralet MC, Navarre M, Eskenazi AM, Lucas-Ross M, Falissard B. Bralet MC, et al. Encephale. 2008 Dec;34(6):557-62. doi: 10.1016/j.encep.2007.12.005. Epub 2008 Jul 9. Encephale. 2008. PMID: 19081451 French.
• Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia.
  Gold S, Arndt S, Nopoulos P, O'Leary DS, Andreasen NC. Gold S, et al. Am J Psychiatry. 1999 Sep;156(9):1342-8. doi: 10.1176/ajp.156.9.1342. Am J Psychiatry. 1999. PMID: 10484943
• A review of neuropsychological differences between paranoid and nonparanoid schizophrenia patients.
  Zalewski C, Johnson-Selfridge MT, Ohriner S, Zarrella K, Seltzer JC. Zalewski C, et al. Schizophr Bull. 1998;24(1):127-45. doi: 10.1093/oxfordjournals.schbul.a033305. Schizophr Bull. 1998. PMID: 9502551 Review.
• Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings.
  Reichenberg A, Harvey PD. Reichenberg A, et al. Psychol Bull. 2007 Sep;133(5):833-58. doi: 10.1037/0033-2909.133.5.833. Psychol Bull. 2007. PMID: 17723032 Review.

Cited by

• Etiologic and Cognitive Differences in Hyperactive and Hypoactive Delirium.
  Kumar A, Bakhla AK, Gupta S, Raju BM, Prasad A. Kumar A, et al. Prim Care Companion CNS Disord. 2015 Nov 12;17(6):10.4088/PCC.15br01810. doi: 10.4088/PCC.15br01810. eCollection 2015. Prim Care Companion CNS Disord. 2015. PMID: 27057400 Free PMC article.
• Toxoplasma gondii seropositivity and cognitive function in adults with schizophrenia.
  Veleva I, Stoychev K, Stoimenova-Popova M, Stoyanov L, Mineva-Dimitrova E, Angelov I. Veleva I, et al. Schizophr Res Cogn. 2022 Aug 27;30:100269. doi: 10.1016/j.scog.2022.100269. eCollection 2022 Dec. Schizophr Res Cogn. 2022. PMID: 36065435 Free PMC article.
• Negative symptoms and cognitive deficits: what is the nature of their relationship?
  Harvey PD, Koren D, Reichenberg A, Bowie CR. Harvey PD, et al. Schizophr Bull. 2006 Apr;32(2):250-8. doi: 10.1093/schbul/sbj011. Epub 2005 Oct 12. Schizophr Bull. 2006. PMID: 16221995 Free PMC article. Review.
• Two Factors, Five Factors, or Both? External Validation Studies of Negative Symptom Dimensions in Schizophrenia.
  Ahmed AO, Kirkpatrick B, Granholm E, Rowland LM, Barker PB, Gold JM, Buchanan RW, Outram T, Bernardo M, Paz García-Portilla M, Mane A, Fernandez-Egea E, Strauss GP. Ahmed AO, et al. Schizophr Bull. 2022 May 7;48(3):620-630. doi: 10.1093/schbul/sbab148. Schizophr Bull. 2022. PMID: 35020936 Free PMC article.
• The Course of Neurocognitive Changes in Acute Psychosis: Relation to Symptomatic Improvement.
  Anda L, Brønnick KS, Johnsen E, Kroken RA, Jørgensen H, Løberg EM. Anda L, et al. PLoS One. 2016 Dec 15;11(12):e0167390. doi: 10.1371/journal.pone.0167390. eCollection 2016. PLoS One. 2016. PMID: 27977720 Free PMC article. Clinical Trial.

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Atypon

• Medical

  • MedlinePlus Health Information